Monday, June 21, 2010

Author interview with Dr Shailesh Gupta

Dr Gupta is currently working on a paper for Clinical Medicine Insights: Endocrinology and Diabetes.

The Editor in Chief of Clinical Medicine Insights: Endocrinology and Diabetes recently issued a call for papers.

Dr Gupta is a member of our favorite authors program. Under the program authors are eligible to receive: prioritized peer review, prioritised author PDF, and an article processing fee discount. All former authors are eligible to join the favorite authors program

What is the primary focus of your research?

Clinical neurophysiology, electrophysiology, Neurology, Sleep medicine and research, Diabetes, Lifestyle clinic, alternative medicine, Biopotentials, brainmapping, biomechanics, sports physiology and medicine.

What are the most exciting developments arising from current research in your area?

Right now we are into neuroprotective ayurvedic drugs and a project for NIH. We are also looking at Diabetes prevalence and lifestyle, and alternative managements.

Who are your main collaborators? Please describe your work with them.

Prof R G Singh, Prof G P Dubey, Prof A K Gupta, Dr M Gourie Devi, Dr Manvir Bhatia and others.

How did you come to be working in your research area?

I chose it, I am in medicine and have been creating my niche, attending courses, conferences, working with eminent people, studying, writing a few books and working on some.

What do you think about the development of open access publishing? What motivated you to do so?

My friend on LA motivated me to start with, its a wonderful idea. More authenticity, more diverse views, comprehensive coverage.

What articles and/or books have you published recently?

I have recently published on Diabetes, Book on medical subjects, Physiology of pregnancy (writing), pregnancy and nutrition, sleep disorders, stroke, Alzheimer's etc.

Friday, June 18, 2010

Interview with Clinical Medicine Insights: Oncology editorial board member Prof. M. Wasif Saif

This interview is with Clinical Medicine Insights: Oncology editorial board member Prof. M. Wasif Saif. Clinical Medicine Insights: Oncology is an open access journal published by Libertas Academica.

Editor in Chief Dr William C S Cho has recently issued a call for papers.

What is the primary focus of your research?

GI Cancers

What are the most exciting developments arising from current research in your area?

Development of novel agents and new targets


Who are your main collaborators? Please describe your work with them.

Collaboration with basic scientists focussed on testing newer agents in preclinical setting and pharmacogenetics.

How did you come to be working in your research area?

Passion and motivation

What do you think about the development of open access publishing? Have you published in an open access journal? What motivated you to do so?

Yes and its a great way of quickly extending your research to others.

What articles and/or books have you published recently?

Many including JCO, Cancer, anticancer drugs, and many others.

Interview with Biomarker Insights editorial board member Dr William CS Cho

This interview is with Biomarker Insights editorial board member Dr William CS Cho. Biomarker Insights is an open access journal published by Libertas Academica.

Editor in Chief Dr Sephen F Kingsmore has recently issued a call for papers.

What is the primary focus of your research?

My main research interests are on some of the local prevalent cancers such as nasopharyngeal carcinoma and non-small cell lung cancer.

I have broad scientific interest in multi-disciplines. As a registered Chinese Medicine Practitioner, apart from cancer, I am keen on immunology, diabetes, proteomics and Chinese medicine.

What are the most exciting developments arising from current research in your area?

My work was featured at utilizing high-throughput mass spectrometry technology and microRNA to discover biomarkers for cancer diagnosis, treatment prediction and prognostication.

Who are your main collaborators? Please describe your work with them.

Some colleagues in the University of Hong Kong.

How did you come to be working in your research area?

After joining the Queen Elizabeth Hospital, I have great interest in studying nasopharyngeal carcinoma, lymphoma and non-small cell lung cancer.

What do you think about the development of open access publishing? Have you published in an open access journal? What motivated you to do so?

This is the trend of publication as it is easy accessible. I have published in an open access journal.

What articles and/or books have you published recently?

I am publishing book on Chinese medicine and cutting-edge technologies in cancer research.

Interview with Biomarkers in Cancer editorial board member Dr Xiaofeng Zhou

This interview is with Biomarkers in Cancer editorial board member Dr Xiaofeng Zhou. Biomarkers in Cancer is an open access journal published by Libertas Academica.

Editor in Chief Dr Barbara Guinn has recently issued a call for papers.

What is the primary focus of your research?

The research in my lab is focused on molecular profiling of oral cancer. We are using oral cancer as a model system to study the molecular mechanisms of epithelial cell tumorigenesis. Oral cancer is an understudied disease. According to ACS Cancer Statistics 2004 to 2008, the new cases and death related to oral cancer increased 25% and 5% respectively, in the past 5 years, while new cases and death of cancer from all sites increased only about 5% and 0.3% respectively during the same period. This represents a major health problem.

My long term goal is to use system biology approaches to understand the initiation and progression of oral cancer, based on surveying large panels of clinical tissue samples and model systems (e.g., cell culture, animal model) that representing milestone events in disease progression (e.g., from precancer to cancer, from primary disease to metastatic disease). This will be achieved in 3 steps: 1) Multi-dimensional data collection at genomics at proteomics levels; 2) Biomarker discovery and molecular modeling of the disease process. Bioinformatic/statistic approaches have been developed to ensure integration of multi-dimensional datasets and modeling of molecular events in tumorigenesis of oral cancer; 3) Clinical and functional validation of the biomarkers and biological models.

What are the most exciting developments arising from current research in your area?

One of our recent research focuses is on microRNAs. It has been realized that microRNAs are widely involved in initiation and progression of cancer. MicroRNAs are sequence specific regulators of posttranscriptional gene expression. This fits very well with our overall research portfolio: multi-dimensional data collection and concurrent data analysis at multiple biological levels. We have been experimenting with various high throughput microRNA profiling platforms, and was able to generate some exciting and clinically relevant outcomes. Our preliminary results led to the identification several microRNA candidates (miR-138 and miR-222) that are relevant to the tumorigenesis of oral cancer (published in Cancer Lett and Cancer Genomics and Proteomics this year). We also received our first microRNA grant this year, which will support our development in this promising area.

Who are your main collaborators? Please describe your work with them.

The multi-disciplinary nature of our research projects requires expertise from several different fields. Just to name a few, I have been collaborating with Dr David Crowe and Joel Schwartz at University of Illinois at Chicago (UIC) in molecular pathology and cancer biology. I have been collaborating with Dr David Wong (UCLA) and Dr Andre Kajdacsy-Balla (UIC) in term of clinical and translational research. I have been collaborating with Chen Li (Harvard), Steve Cole (UCLA) and Tianwei Yu (Emory) in the areas of data analysis and statistical modeling.

A major objective of my research is to improve the clinical management of the oral cancer patients. To facilitate the eventual translation of my research findings, I am continuously building clinical collaborations in the US and abroad (China and Italy). I am also holding a joined appointment (Visiting Professor) and have an active research project at Sun Yat-sen University in Guangzhou, China, where oral cancer is a major health problem. I am planning to perform discovery phase of the study based on US population and then validate my findings in China and Italy populations, which is an ideal approach for genetic studies: discovery in one population and validate in independent populations with similar etiologies.

How did you come to be working in your research area?

My mother is a chemist. I was kind of growing up in a laboratory. I was pretty sure I wanted to be a scientist when I was very young. However it took a while for me to finally settle into my current research area. My first research position was in biophysics, focused on the biophysical properties of muscle proteins. After this first real exposure to research, I then pursued a Ph.D. in Biochemistry. Following my Ph.D. training, I was fortunate to have a post-doc training in 2 different, yet interconnected areas, namely genomics and bioinformatics. I also earned a M.S. degree in Software Engineer.

With all these exposures to various exciting, but fairly diverse research fields, it is somewhat difficult to choose a focus area to pursue as a career. Eventually, at the end of my post-doc training, I came to the realization that I want to have a multi-disciplinary research project focus on one of the under-studied and under-treated diseases. Oral cancer is one of those diseases.

What do you think about the development of open access publishing? Have you published in an open access journal? What motivated you to do so?

I believe that open access publishing is very important. It facilitates the exchange of research data and scientific progress. For scientists, it definitely improves the visibility of your works. I believe this is one of the most important motivation for publishing in open access journals. We have recently published a number of articles in open access journals, including:

T. Yu, H. Ye, W. Sun, KC. Li, Z. Chen, S. Jacobs, DK. Bailey, DT. Wong, X. Zhou. A forward-backward fragment assembling algorithm for the identification of amplification and deletion breakpoints using high-density single nucleotide polymorphism (SNP) array. BMC Bioinformatics (2007) 8:145.

X. Zhou, J. Cui, V. Macias, A. Kajdacsy-Balla, H. Ye, J. Wang, P.N. Rao. The progress on genetic analysis of nasopharyngeal carcinoma. Comp Funct Genomics (2007) Article ID 57513, 1-13.

H. Ye, T. Yu, S. Temam, B.L. Ziober, J. Wang, J.L. Schwartz, L. Mao, D.T. Wong, X. Zhou. Transcriptomic dissection of tongue squamous cell carcinoma. BMC Genomics (2008) 9:69.

X. Liu, Z. Chen, J. Yu, J. Xia, X. Zhou. MicroRNA profiling and head and neck cancer. Comp Funct Genomics (2009) vol. 2009, Article ID 837514, 11 pages. doi:10.1155/2009/837514 A.

Wang, X. Liu, S. Sheng, H. Ye, T. Peng, F. Shi, D.L. Crowe, X. Zhou. Dysregulation of heat shock protein 27 expression in tongue squamous cell carcinoma. BMC Cancer (2009) 9(1):167.

Further Information

Faculty Website

Interview with Microbiology Insights editorial board member Dr Viroj Wiwanitkit

This interview is with Microbiology Insights editorial board member DrViroj Wiwanitkit. Microbiology Insights is an open access journal published by Libertas Academica.

Editor in Chief Dr Raul Rivas has recently issued a call for papers.

What is the primary focus of your research?

Tropical medicine, public health, infectious disease, laboratory medicine.

What are the most exciting developments arising from current research in your area?

Many reports on infectious diseases including the new emerging ones.

Who are your main collaborators? Please describe your work with them.

Many researchers in the field from around the world on infectious diseases and micrological research.

How did you come to be working in your research area?

Expertise in this field

What do you think about the development of open access publishing? Have you published in an open access journal? What motivated you to do so?

It is a good choice and new development in medical journalism. I have published many papers in open assess journal. It is really the new advent in the field.

What articles and/or books have you published recently?

More than 520 papers in international level, more than 40 books/chapters in international level.

Thursday, June 17, 2010

Interview with Cell & Tissue Transplantation & Therapy editorial board member Dr Terje Forslund

This interview is with Cell & Tissue Transplantation & Therapy editorial board member Dr Terje Forslund. Cell & Tissue Transplantation & Therapy is an open access journal published by Libertas Academica.

Editor in Chief Dr David T Harris has recently issued a call for papers.

What is the primary focus of your research?

Kidney diseases, hypertension, vascular active peptides (like renin, angiotension, atrial natriuretic peptide, endothelin), regulative mechanisms in renal failure.

What are the most exciting developments arising from current research in your area?

At beginning of my research career I was introduced to the renin-angiotensin system and angiotensin converting enzyme (ACE). In our first experiments with ACE inhibitors in 1978 we were able to show that inhibition of ACE with captopril decreased the heart/body weight index in spontaneously hypertensive rats pointing to prevention and regression of left ventricular hypertrophy. Although never much referred in the literature, we were probably the first in the world to show this phenomenon. ACE inhibition was later on shown to be the case also in hypertensive patients.

Who are your main collaborators? Please describe your work with them.

My most important collaberator was Professor Frej Fyhrquist, Professor in Internal Medicine, Helsinki University, Helsinki, Finland. He was the one to lead me on with experimental research, resulting in several publications in the field described above.

Professor Bjarne M. Iversen, Institute of Medicine, University of Bergen, Bergen, Norway, also has contributed to my interest in experimental glomerulonephritis during my stay in Bergen in the years 1998 - 2000. Several other collegues also has participated and given their contribution to my research and Associate Professor Ilkka Tikkanen, Helsinki University Hospital, Helsinki, Finland was an important teacher in how to measure blood pressure in the rat tail. Later on, my course of reasecrh has been more in the clinical sphere.

How did you come to be working in your research area?

I was a general practitioner from 1972 until 1978 at which point of time I went to Helsinki University in order to be a specialist in Internal Medicine and Nephrology. Early after arriving at Department of Internal Medicine, at Department of Medicine I was introduced to Professor Fyhrquist who inspired me to do experimental research, resulting in a doctors thesis in 1984, and thereafter also urged me to continue in research beside my clinical work at hospital as a nephrologist.

What do you think about the development of open access publishing? Have you published in an open access journal? What motivated you to do so?

I have several publication in many journals, both in non-open access as in open-access journals. The motivation to use open access journals too, came from the fact that several of non-open access journals do have a non-acceptable policy. Firstly, in many of these journals the researcher pays for the article to be published and if you want to read articles in that same journal you have to pay again. This is also the case for hospitals that use enormous amounts of money to obtain the literature needed. Another aspect is that the time sequence from submitting a manuscript until decision may take very long, which may give rise to suspicion of copying ideas. (Our first paper, the time from submittance to negative decision was 9 months, obstructing us to publish it in another journal).

What articles and/or books have you published recently?

Lately I have mostly published case reports with a clinical importance, of which some are listed below:

Leh S, Vaagnes Ø, Margolin SB, Iversen BM, Forslund T. Pirfenidone and candesartan ameliorate morphological damage in mild chronic anti-GBM nephritis in rats. Nephrol. Dial. Transplant. 2005; 20: 71 - 82 Forslund T et al. IgA nephropathy in a patient with IgG lambda light-chain plasmacytoma; a rare coincidence. Nephrol Dial Transplant 2007; 22: 2705 - 2708.

Forslund T et al. Mesangial proliferative glomerulonephritis after autologous stem cell transplantation; a case report. Am J Kidney Dis 2006; 48: 314 - 320.

Forslund T et al. Malignant myeloma in a patient after treatment for osteoporosis with teriparatide; a rare coincidence. Clinical Med: Case Reports 2008; 1: 119 – 122.

Forslund T et al. Experience with Cinacalcet treatment in patients with predialytic stage III and IV chronic renal failure and secondary hyperparathyroidism. Clinical Medicine: Therapeutics 2009 (in press).

Contributed with a chapter in a book:

Forslund T. Stem cell transplantation in leukemia: The kidney. In: Stem Cell Transplantation, Tissue Engineering and Cancer Applications. Eds: Bernard N. Kennedy. Novo Science Publishers, NY, USA, 2008 (ISBN: 978-1-60692-107-4; in print).

Interview with Nutrition and Metabolic Insights editorial board member Prof.Abdulaziz I.AL-Othaimeen

This interview is with Nutrition and Metabolic Insights editorial board member Prof. Abdulaziz I.AL-Othaimeen. Nutrition and Metabolic Insights is an open access journal published by Libertas Academica.

Editor in Chief Dr Dexter Canoy has recently issued a call for papers

What is the primary focus of your research?

My research focuses on epidemiology of nutritional health problems, obesity, fortification of foods, and diet-disease relationship. The principal investigator for two major studies on the causal association between dietary fat intake and breast cancer, Saudi diet as preventive of prostate cancer.

What are the most exciting developments arising from current research in your area?: Improve the consideration of diet as an important risk factors for preventions and as tool for treatment of chronic diseases and under-nutrition.

Who are your main collaborators? Please describe your work with them.

I am working as senior scientist at resarch centre King Faisal sp. hospital and I collaborate with other scientists and clinicians in form of research projects

How did you come to be working in your research area?

As I accomplished my Ph.D. in Food habits and patterns of diseases in Saudi Arabia I was appointed at the research centre.

What do you think about the development of open access publishing? Have you published in an open access journal? What motivated you to do so?

I believe it will be a good tools to share information in fast and easy access way.

What articles and/or books have you published recently?

A.I. Al-Othaimeen,1 M. Al-Nozha2 and A.K. Osman3"Obesity :an emerging problem in Saudi Arabia Analysis of data fom National Nutritional Survey "Eastern Mediterranean Health Journal, Vol. 13, No. 2, 2007.

A Alothaimeen, A. Ezzat, G. Mohamed, T. Muammar and A. Al-Madouj (2004). Dietary fat and breast cancer in Saudi Arabia: a case-control study. Eastern Mediterranean Health Journal 10(6): 879-886.

Ali Karar Osman, A.I.Alothaimeen”Experience with ferrous bis-glycinate chelate as an iron fortificant in milk”Int J Vit Nutr Res (2002) 72:257-263.

Wednesday, June 16, 2010

Interview with Biomarker Insights editorial board member Dr Steven R. Myers

This interview is with Biomarker Insights editorial board member Dr Steven R. Myers. Biomarker Insights is an open access journal published by Libertas Academica.

Editor in Chief Dr Stephen F Kingsmore has recently issued a call for papers.

What is the primary focus of your research?

Dr. Steven R. Myers, is currently Associate Professor of Pharmacology and Toxicology at the University of Louisville School of Medicine. Dr. Myers' research focuses on the development and utilization of biological markers of environmental carcinogen exposure, particularly in smokers and non-smokers. Dr. Myers' research undertakes a variety of experiments to assess exposure of human populations to both environmental tobacco smoke as well as other sources of environmental contaminants that potentially can cause developmental, gestational, and postnatal disease. The research of Dr. Myers gains insightful information as to the levels of compounds exposed to individuals, as well as the developing fetus. Through his work in dealing with fetal exposure to tobacco carcinogens during pregnancy, new revelations have been found as to the potential harmful effects of environmental as well as tobacco related carcinogens on the developing fetus! These studies are continuing in coordination with several area hospitals and work is currently investigating relationships between individual carcinogens found in tobacco with specific alterations in enzymes in the mother and in the neonate as well as both DNA and protein damage.

Other areas of investigation and Dr. Myers' laboratory includes development and application of biomarkers of exposure to environmental carcinogens in a variety of areas of the United States in conjunction with the United States Environmental Protection Agency as well as in studies carried out in the Czech Republic as well as in China, both of these areas being some the most polluted areas in the world. A new area of investigation currently under study is the application and utility of breast milk as a biomarker of exposure to a variety of carcinogens resulting from mothers smoking during pregnancy. This area of research will yield exciting new information as to the postnatal effects of tobacco carcinogens on the infant as a consequence of breast feeding. Dr. Myers has been actively involved in the field of chemical carcinogenesis for over 25 years and has published over 100 peer-reviewed articles and abstracts related to his research. He has presented his research at numerous invited presentations and has given seminars throughout the world on his biomarker and carcinogen research. He is currently editor of the Journal Polycyclic Aromatic Compounds published by Taylor and Francis publishing group.

What are the most exciting developments arising from current research in your area?

Development of Biomarkers of tobacco smoke in the neonate as a result of maternal smoking during pregnancy. Correlations between maternal smoking habits and preterm labor and delivery and neonatal birth weights. In addition, we have developed assays for the detection of over 30 Polycyclic aroamtic hydrocarbons found in auto/diesel exhausts, coal-fired plants, etc and use these biomarkers as methods of source apportionment related to exposures. Recently, the application of proteomics in the field of biomarkers has allowed us to discover new protein modification caused by tobacco exposures, particularly in the neonate, which may assist in the uncovering of etiology of disease resulting from in utero smoke exposure.

Who are your main collaborators? Please describe your work with them.

Dr. Harrell E. Hurst, collaboration on mass spectrometry Dr. David Adamkin, collaboration on preterm labor and gestation as a result of smoking Dr. Paula Radmacher, collaboration of PAH biomarkers in breast milk Dr. David Hein, collaboration on genotyping

How did you come to be working in your research area?

Undergraduate degree in Chemistry, Masters in Physiology, Doctorate in Pharmacology and Toxicology, Post-doctoral work in Biochemistry at the Univ Chicago..Graduate work was in metabolism of aromatic hydrocarbons, and relationships between structure and activity with regard to cancer. Pursued biochemistry in Post-Doc, and applied biochemistry of amino acids to potential biomarkers as a result of exposure to PAHs. Found the area intriguing as compared to studying modification of DNA adducts.

What do you think about the development of open access publishing? Have you published in an open access journal? What motivated you to do so?

Yes, we have published in the past in the open access field. Excellent format to publish rapid manuscripts....Availability over the internet, wide dissemination of publications and rapidness of publication is the method of choice for researchers in the 21st century.


What articles and/or books have you published recently?

Myers, Steven R. and Ali, M. Yeakub. Haemoglobin as a biomarker for tobacco-related nitrosamines, Biomarkers 12(8): 1 – 15, 2007.

Myers, S.R., Bioalkylation of Benz(a)anthracene: Implications for Carcinogenesis, Journal of Polycyclic Aromatic Compounds, 27(4): 311 – 337, 2007.

Myers, S.R., Ali, M. Y., Wright, T., and Cunningham, C. Benzo(a)pyrene Metabolism: Role of Bioalkylation, Journal of Polycyclic Aromatic Compounds 27(4):339 – 359, 2007.

Myers, S.R. and Ali, M. Y., Determination of Tobacco Specific Hemoglobin Adducts in Smoking Mothers and NewBorn Babies by Mass Spectrometry., Biomarker Insights 2:269–282, 2007.

Myers, S.R. and Spinnato, J.A., Tissue distribution and elimination of N -methyl- N -2,4,6-tetranitroaniline (tetryl) in rats, Archives of Toxicology, 81(12): 841-848, 2007.

Myers, S.R. and Spinnato, J.A., Metabolism, tissue distribution, and pharmacokinetics of N-methyl-N-2,4,6-tetranitroaniline (tetryl) Environmental Toxicology and Pharmacology, 24(3): 206 -211, 2007.

Sumanasekera, W. K., Ivanova, M. M., Johnston, B. J., Dougherty, S. M., Sumanasekera, G. U., Myers, S. R., Ali, M. Y., Kizu, R., and Klinge, C. M., Rapid effects of diesel exhaust particulate extracts on intracellular signaling in human endothelial cells. Toxicology Letters, 174(1-3): 61-73, 2007.

Myers, S.R., Zamora, R., Ali, M. Y., Cunningham, C. R., Wright, T., and Weeks, J. Analysis of Polycyclic Aromatic Hydrocarbons in Amniotic Fluid Samples from Smokers and Nonsmokers, Journal of Polycyclic Aromatic Compounds 28(1): 39 – 66, 2008.

Myers, S.R., Hurst, H.E., Cunningham, C., Ali. M. Y., and Wright, T., Kinetics of Formation of (±)-anti-7, 8-dihydroxy-9α,10α-epoxy-7, 8, 9, 10-tetrahydrobenzo[a]pyrene Adducts with Mouse and Human Hemoglobin, Journal of Polycyclic Aromatic Compounds, Accepted for publication, January, 2008.

Myers, Steven R., Christopher R. Cunningham, Terry Wright, and Jonathan Weeks, “Levels of Polycyclic Aromatic Hydrocarbons in Amniotic Fluid Samples from Smokers and Nonsmokers,” Society of Maternal and Fetal Medicine, February 2 – 7, New Orleans, LA, 2004.

JW Weeks, CR Cunningham, and SR Myers, “Self-Reporting of Cigarette Consumption During Pregnancy”, Society of Maternal and Fetal Medicine, February 2 – 7, New Orleans, LA, 2004.

Joellen Lewtas, Steven Myers, Christopher Simpson, Russell Dill, David Kalman, “Development of Urinary Metabolite Biomarkers to Assess Population Exposure to 00PM2.5 from Various Combustion Sources,” PM2.5 meeting, Univ. Washington, 2004.

Christopher Cunningham, Terry Wright, Harrell Hurst, and Steven R. Myers, “Characterization of Epoxide Adducts of Polycyclic Aromatic Hydrocarbons with Hemoglobin,” American Association for Cancer Research, Orlando, FL, 2004.

Steven R. Myers, Christopher R. Cunningham, Terry Wright, and Jonathan Weeks, “Levels of Polycyclic Aromatic Hydrocarbons in Amniotic Fluid Samples from Smokers and Nonsmokers.” American Association for Cancer Research, Orlando, FL, 2004.

Myers, S.R., Cunningham, C, Wright, T. and Hurst, H.E. “Kinetics of reaction of epoxide metabolites of polycyclic aromatic hydrocarbons with human and mouse hemoglobin.” 43rd Annual Meeting, Society of Toxicology, Baltimore, MD, March 22, 2004.

Steven R. Myers, Christopher Cunningham, and Jonathan Weeks, “Levels of Polycyclic Aromatic Hydrocarbons in Amniotic Fluid Samples from Smokers and Nonsmokers,” State EPSCoR meeting., Feb, 2004.

Christopher Cunningham, Terry Wright, Harrell Hurst, and Steven R. Myers “Characterization of Epoxide Adducts of Polycyclic Aromatic Hydrocarbons with Hemoglobin” State EPSCoR meeting., Feb, 2004.

Weeks, Jonathan, Myers, Steven R., “Levels of Polycyclic Aromatic Hydrocarbons in Amniotic Fluid Samples from Smokes and Nonsmokers,” Society of Toxicology Meeting, March 6 – 11, New Orleans, LA., 2005.

Ali, M Y., Hurst, Harrell E., and Myers, Steven R., “Characterization of Epoxide Adducts of Polycyclic Aromatic Hydrocarbons (PAHs) with Hemoglobin (Hb)”, Society of Toxicology Meeting, March 6 – 11, New Orleans, LA., 2005.

Myers, Steven R., Cunningham, Christopher; and Wright, Terry, “Correlations of Maternal Hemoglobin (Hb) 4-Aminobiphenyl Adduct Levels with Respect to Cotinine levels and Maternal Genotypes.” Society of Toxicology Meeting, March 6 – 11, New Orleans, LA, 2005.

Cunningham, Christopher, Wright, Terry , and Myers, Steven R., “Correlation of Maternal and Fetal Hemoglobin (Hb) Addcuts in Smokers with Respect to Genotype,” Society of Toxicology Meeting, March 6 – 11, New Orleans, LA, 2005.

Wright, Terry, Cunningham, Christopher, and Myers, Steven R., “Relationship between CYP1A1 Genotype and Benzo(a)pyrene (BP) Hemoglobin (Hb) Adducts in Maternal and Fetal Blood”, Society of Toxicology Meeting, March 6 – 11, New Orleans, LA, 2005.

Myers, S.R. and Ali, Md. Y. “Characterization and kinetics of polycyclic aromatic hydrocarbon hemoglobin adducts in mice.” The 20th International Meeting of the International Society for Polycyclic Aromatic Compounds, August, Toronto, CA., 2005.

Myers, S.R. and Weeks, J. “Polycyclic aromatic hydrocarbon levels in amniotic fluid samples from smokers: correlation with smoking status”. The 20th International Meeting of the International Society for Polycyclic Aromatic Compounds, August, Toronto, CA, 2005.

Myers, S.R., Cunningham, C., Wright, T., and Ali, Md. Y., “Biomarkers of polycyclic aromatic hydrocarbon exposure: Application of protein adducts in Toxicology.” International Meeting of the International Society for Polycyclic Aromatic Compounds, August, Toronto, CA, 2005.

Zamora, R. and Myers, S.R. Amniotic Fluid Biomarkers of Tobacco Smoke Exposure During Pregnancy, Research Louisville!!, October, 2007.

Radmacher, P., Adamkin, D., Myers, S.R., and Looney, S. A Pilot Study of Polycyclic Aromatic Hydrocarbons (PAHs) in Maternal and Cord Blood Plasma, Society of Perinatal Medicine Research, New Orleans, LA, February 21 – 25, 2008.

Myers, S.R., Ali, M. Y., Radmacher, P., and Adamkin, D. Nitrosoamine Hemoglobin adducts in Maternal and Fetal Blood Samples from Smokers and Nonsmokers., Society of Perinatal Medicine Research, New Orleans, LA, February 21 – 25, 2008.

Myers, S.R., Ali, M. Y., Radmacher, P., and Adamkin, D. Analysis of Polycyclic Aromatic Hydrocarbons in Breast Milk from Smokers and NonSmokers. Society of Perinatal Medicine Research, New Orleans, LA, February 21 – 25, 2008.

119. Myers, S.R., Ali, M. Y., Radmacher, P., and Adamkin, D. Amniotic Fluid as a Biomarker of Exposure to Tobacco Carcinogens., Society of Perinatal Medicine Research, New Orleans, LA, February 21 – 25, 2008.

Myers, S.R., Ali, M. Y., Radmacher, P., and Adamkin, D. Maternal and Fetal Cytokine Concentrations in Smokers and Nonsmokers at Childbirth., Society of Perinatal Medicine Research, New Orleans, LA, February 21 – 25, 2008.

Interview with Immunology and Immunogenetics Insights editorial board member Dr Robert Yarchoan

This interview is with Immunology and Immunogenetics Insights editorial board member Dr Robert Yarchoan. Immunology and Immunogenetics Insights is an open access journal published by Libertas Academica.

Editor in Chief Dr Darren Flower has recently issued a call for papers.

What is the primary focus of your research?

A main focus of my work is translational research in HIV-associated tumors, especially those caused by Kaposi's sarcoma-associated herpesvirus (KSHV), also called human herpesvirus-8 (HHV-8). In the laboratory, we are exploring the physiologic factors that activate KSHV to lytic replication and ways to use this to target KSHV tumor cells, and in the clinic, we are exploring novel treatments for Kaposi's sarcoma (KS) and KSHV-induced multicentric Castleman's disease (MCD). My laboratory is also studying the protease of HIV and in particular, the factors affecting dimerization of this enzyme and ways to modulate this.

What are the most exciting developments arising from current research in your area?

We have found that hypoxia incudes lytic replication of KSHV and in addition, specifically activates certain KSHV genes such as open reading frame (ORF) 34. Furthermore, we have found that lytic KSHV genes can activate azidothymidine (AZT, zidovudine) and ganciclovir to moieties that are toxic to human cells, potentially specifically targeting KSHV-infected tumor cells. We are exploring the use of this approach to treat KSHV-MCD, a tumor in which the main clinical profile results from production of a viral IL-6 encoded by KSHV.

Who are your main collaborators? Please describe your work with them.

Some of the collaborators we are working with include Drs. Denise Whitby and Giovanna Tosato (National Cancer Institute) on KSHV virology, Hiroaki Mitsuya (National Cancer Institute) on HIV protease, and Amir Gandjbakhche (National Institute of Child health and Human Development) on novel imaging techniques of KS.

How did you come to be working in your research area?

My career has evolved over the years from studying the interactions between viruses and the immune system (focusing on influenza virus and Epstein Barr virus), to work on developing early therapies for AIDS - including codevelopment of AZT, didanosine (ddI), and other early drugs - to studying AIDS-related malignancies. The finding that KSHV is activated by hypoxia was inspired by the clinical observation that KS preferentially affects the feet, and area of the body with low tissue oxygen.

What do you think about the development of open access publishing? Have you published in an open access journal? What motivated you to do so?

This development in exchange of scientific information was championed by Dr. Harold Varmus, the previous NIH Director. It will be interesting to see how the publishing landscape evolves over the next decade.

What articles and/or books have you published recently?

Selected recent articles and chapters are as follows:

1. Yarchoan, R. Clinical Implications of Basic Research: Key role for a viral lytic gene in Kaposi’s sarcoma. New Engl J. Med., 2006; 355(13): 1383-1385.

2. Davis DA, Singer KE, Reynolds IP, Haque M, Yarchoan R. Hypoxia enhances the phosphorylation and cytotoxicity of ganciclovir and zidovudine in KSHV-infected cells. Cancer Research. 2007; 67(14): 7003-10.

3. Yarchoan R, Pluda JM, Wyvill KM, Aleman K, Rodriguez-Chavez IR, Tosato G, Catanzaro AT, Steinberg SM, Little RF. Treatment of AIDS-related Kaposi’s sarcoma with interleukin-12: Rationale and preliminary evidence of clinical activity. Critical Reviews in Immunology. 2007; 27(5), 401-14.

4. Little RF, Pittaluga S, Yarchoan R. Non-Hodgkin lymphoma. In: Dolin R, Masur H, Saag MS, Eds. AIDS Therapy, 3rd Edition. Churchill Livingstone/Elsevier, Philadelphia. 2007; 1031-1050.

5. Vogel A, Chernomordik VV, Riley JD, Hasssan M, Amyot F, Dasgeb B, Demos SG, Pursley R, Little R, Yarchoan R, Tao Y, Gandijbakhche AH. Using noninvasive multispectral tissue imaging to quantitatively assess tissue vasculature. J. of Biomedical Optics 2007;12(5): 051604-17.
6. Little RF, Aleman K, Kumar P, Wyvill KM, Pluda JM, Read-Connole E, Wang V, Pittaluga S, Catanzaro AT, Steinberg SM, Yarchoan R. Phase II study of pegylated liposomal doxorubicin in combination with interleukin-12 for Kaposi’s sarcoma. Blood. 2007; 110(13), 4165-71.

7. Yarchoan R, Little RF. AIDS-related malignancies. In: DeVita VT Jr., Lawrence TS, and Rosenberg SA, Eds., Cancer: Principles and Practice of Oncology, 8th Edition. Lippincott Williams and Wilkins, Philadelphia. 2008; 2401-17.

8. O’Mahony D, Gandjbakhche AH, Hassan M, Vogel A, Yarchoan R. Imaging techniques for Kaposi sarcoma (KS). Journal of HIV Therapy. 2008; 13(3): 65-71.

Further Information

Faculty Website

Principal Investigator Webpage

Tuesday, June 15, 2010

Interview with International Journal of Tryptophan Research editorial board member Dr Martin Reuter

This interview is with International Journal of Tryptophan Research editorial board member Dr Martin Reuter. International Journal of Tryptophan Research is an open access journal published by Libertas Academica.

Editor in Chief Dr Gilles Guillemin has recently issued a call for papers.

What is the primary focus of your research?

My primary focus of research is on the biological basis of individual differences in behavior - ranging from normal behavior to psychopathology. Thereby I try to combine different research methods: molecular genetics, functional imaging, experimental tests, and self-reports.

What are the most exciting developments arising from current research in your area?

Most people in the population believe that genes refer to somethinc static, inherited by birth that determines your behavior throughout life. However, most of them do not know that our behavior can influence our genes via having an effect on gene expression. Therefore, epigenetics is a field that will bring new insights into the interplay of environment and genes. This means that crucial life events determine whether risk factors for certain traits or diseases become active. New developments in molecular genetics make it possible to investigate epigenetic effects by looking for changes in the methylation of our genes.

Who are your main collaborators? Please describe your work with them.

Oh, there are many. At present I establish a new Center for Neuroeconomics together with colleagues from the medical (Prof. Elger & Dr. Weber) and the economics department at the University of Bonn. Here we try to investigate the neural basis of humnan decision making in economic contexts. Moreover, I cooperate with Prof. Kirsch from the ZI-Mannheim. We are conducting a genetic imaging study investigating the effects of oxytocin on the processing of emotions....there are so many projects - I can not describe all of them.

How did you come to be working in your research area?

I am psychologist. The three main constructs of psychology and therefore for human and animal behavior are cognition, emotion, and motivation. In the past the majority of psychologists have ignored that these three constructs are regulated in the brain. In my eyes it is the greatest adventure to explore the neural and biochemical underpinnings of behavior. I think that it is not satisfactory to just describe behavior or to have skills how to change behavior. The challenge is to understand behavior from the molecule to the overt behavior. Today my main research tool is genetics. As a psychologist I had no training in genetics. I did this autodidactic. My fascination for science was inspired by my former diploma thesis supervisor Prof. Netter.

What do you think about the development of open access publishing? Have you published in an open access journal? What motivated you to do so?

I have just an article under review in an open access journal and I will also choose open access journals in the future. The advantage is that open access journals make science available for all. My motivation to publish in an open access journal increases more and more because some of them have achieved a very good reputation in the scientific field (impact factor).

What articles and/or books have you published recently?

1: The biological basis of anger: associations with the gene coding for DARPP-32 (PPP1R1B) and with amygdala volume. Reuter M, Weber B, Fiebach CJ, Elger C, Montag C. Behav Brain Res. 2009 Sep 14;202(2):179-83. Epub 2009 Apr 1. PMID: 19463699 [PubMed - in process]

2: The BDNF Val66Met polymorphism impacts parahippocampal and amygdala volume in healthy humans: incremental support for a genetic risk factor for depression. Montag C, Weber B, Fliessbach K, Elger C, Reuter M. Psychol Med. 2009 Apr 1:1-9. [Epub ahead of print]
PMID: 19335934 [PubMed - as supplied by publisher]

3: COMT genetic variation affects fear processing: psychophysiological evidence. Montag C, Buckholtz JW, Hartmann P, Merz M, Burk C, Hennig J, Reuter M. Behav Neurosci. 2008 Aug;122(4):901-9.

4: Genetically determined differences in learning from errors. Klein TA, Neumann J, Reuter M, Hennig J, von Cramon DY, Ullsperger M. Science. 2007 Dec 7;318(5856):1642-5. PMID: 18063800 [PubMed - indexed for MEDLINE]

Further Information

Faculty Website

Interview with Cancer Informatics editorial board member Dr Philip Crooke

This interview is with Cancer Informatics editorial board member Dr Philip Crooke. Cancer Informatics is an open access journal published by Libertas Academica.

Editor in Chief Dr James Willey has recently issued a call for papers.

What is the primary focus of your research?

Mathematical modeling of physiological processes of diseases and developing algorithms to diagnose and treat these diseases.

What are the most exciting developments arising from current research in your area?

1. A mathematical model to predict the risk of breast cancer.
2. A genetic-based algorithm to identify autoimmune diseases.
3. A clinically relevant model for mechanical ventilation that attempts to minimize lung injury.

Who are your main collaborators? Please describe your work with them.

1. Fritz F. Parl (Pathology-Vanderbilt)
2. Thomas M, Aune (Rheumatology-Vanderbilt)
3. John R. Hotchkiss (Critical Care Medicine-University of Pittsburgh)
Our projects always involve mathematical models that use experimental data to verify the model. The utility of the model is its application to a particular branch of medicine.

How did you come to be working in your research area?

Initially, it was by chance. After my colleagues in the School of Medicine at Vanderbilt learned of my interest in working with clinicians and medical researchers, I was approached to join their projects. I am hardly ever the initiator of these projects.

What do you think about the development of open access publishing? Have you published in an open access journal? What motivated you to do so?

I believe that it will play an important role in publishing. However, I am afraid that it may be too expensive for individual researchers.

What articles and/or books have you published recently?

J.R. Hotchkiss, D.G. Strike and P.S. Crooke. Pathogen transmission and clinic scheduling, Emerging Infectious Diseases 12 2006, pp. 159-162.

S. Hota, A.B. Adams, J.R. Hotchkiss and P.S. Crooke. Optimal phasic tracheal gas insufflation timing: an experimental and mathematical analysis, Critical Care Medicine 34 2006, pp.1408-1414.

P.S. Crooke, Ritchie, D.L. Hachey, S. Dawling, N. Roodi, and F.F. Parl. Estrogens, enzyme variants, and breast cancer: A risk model. Cancer Epidemiology, Biomarkers and Prevention 15 2006, pp. 1-10.

S.C. Fossey, C. Vnencak-Jones, N. Olsen, S. Subramaniam,G. Garrison, X. Deng, P.S. Crooke and T. Aune. Identification of molecular biomarkers for multiple sclerosis, The Journal of Molecular Diagnoistics 9(2007), 197-204.

J.R. Hotchkiss, M.H.Sanders, G. Clermont and P.S. Crooke. Preventing “bored-lung disease” when treating patients with ventilatory failure. Critical Care Medicine 35(2007), 1797-1799.

P.S. Crooke, S. Rattnamongkonkul, Y. Lenbury, and J.R. Hotchkiss. Mathematical modeling of non-invasive pressure support ventilation: investigation of tidal volume instability in Quantitative Medical Data Analysis Using Mathematical Tools and Statistical Techniques, edited by D. Hong and Y. Shyr, World Science Publishing Co., 2007, 277-296.

J.R. Hotchkiss, P. Holley and P.S. Crooke. Analyzing pathogen transmission in the dialysis unit: Time for a (schedule) change? Clinical Journal of the American Society of Nephrology 2(2007).

J.S. Rankin, A.F. Daley, P.S. Crooke and R.H. Anderson. A ‘hemispherical’ model of aortic valvar geometry, J. Heart Valve Disease 17(2008), 179-186.

F.F. Parl, S. Dawling, N. Roodi and P.S. Crooke. Estrogen metabolism and breast cancer. Ann. N.Y. Acad. Sci. 1155(2009), 68-75.

Further Information

Faculty Website

Interview with Environmental Health Insights editorial board member Dr Lalita Bharadwaj

This interview is with Environmental Health Insights editorial board member Dr Lalita Bharadwaj. Environmental Health Insights is an open access journal published by Libertas Academica.

Editor in Chief Dr Timothy Kelley has recently issued a call for papers.

What is the primary focus of your research?

I am a Toxicologist with expertise in the areas of Human and Environmental Health Risk Assessment. I have conducted a variety of risk assessments for specific contaminated sites, explicit and unique exposure scenarios and for materials used in the construction industry. My research involves assessing potential health risks to rural, remote and Indigenous Communities associated with long-term low-level exposures to environmental chemical contaminants through water (primarily), soil and air. Research approaches involve the use of animal, tissue and cell culture models of exposure, the application of toxicogenomics and the employment of community-based participatory methods. A large focus of my research involves the assessment of drinking water issues for National and International Indigenous Communities, with emphasis on the health impacts to children, families and their communities as a result of poor access to clean, safe sustainable drinking water sources. I also foster the development of secondary and post-secondary students through application of community based education models in research activities.

What are the most exciting developments arising from current research in your area?

Our lab demonstrated for that environmentally realistic levels of drinking water contaminants such as arsenic 2,4-D and nitrate induce gene expression changes in exposed human cell lines. I am currently working with the Federation of Saskatchewan Indian Nations to assess the issues and barriers associated with the poor access to safe and sustainable drinking water in these communities and together have developed a Safe Drinking Water Program.

Who are your main collaborators? Please describe your work with them.: I am involved in Community Based Participatory Reserach so my main collaborators are community members although I collaborate with other academics in the fields of toxicology, hydrology, engineering and community health and epidemiology.

How did you come to be working in your research area?

I became interested in my research area through a passion for applied research in the area of toxicology, interest in the areas of human and environmental health risk assessment and in generating research data, through the use of community based participatory research methods, that is useful and meaningful and can be shared and utilized by communities.

What do you think about the development of open access publishing? Have you published in an open access journal? What motivated you to do so?

Open access publishing is great. It allows for greater dissemination of knowledge.

What articles and/or books have you published recently?

Publications (last 6 years)
Bharadwaj, L., Machibroda, R., (2008) Saskatoon Rehabilitates its South Downtown Riverbank Area. Environmental Science and Engineering 21(3): 54-58.

Nilson, S., Bharadwaj, L., Hill, V., & Knockwood, D. (2008) Science in a Circle: Forming Community Links to Conduct Scientific Research in Partnership with Communities. Pimatisiwin: A Journal Of Indigenous and Aboriginal Community Health 6(1) 123-136.

Bharadwaj, L., Judd-Henrey, I., Parenteau, L., Tournier, C., & Watson, D., (2008) Solid Waste Incineration in a Saskatchewan First Nation Community: A Community-Based Environmental Assessment of Dioxins and Furans. Pimatisiwin: A Journal Of Indigenous and Aboriginal Community Health 6(1) 161-180.

Bharadwaj, L., Machibroda, R., (2008) Human Health Risk Assessment Approach for Urban Park Development. Accepted for Publication July 2008. Archives of Industrial Hygiene and Toxicology 59:213-223.

Bharadwaj, L., Nilson, S., Judd-Henrey, I., Oullette, G., Parenteau, L., Tournier, C.,Chief Daryl Watson, Chief Darcy Bear, Chief Gilbert Ledoux, Chief Austin Bear (2006) Waste Disposal in First Nations Communities: The Issues and Steps Toward the Future. Journal of Environmental Health, March 206 Issue: 35-38.

Bharadwaj, L.A., Dhami, K., Schneberger, D., Stevens, M., Conde, R., Ali, A., (2005). Altered gene expression in human hepatoma hepG2 cells exposed to low-level 2, 4-dichlorophenoxyacetic acid and potassium nitrate. Toxicology In Vitro 19:603-619.

Davies F.G., Roesler W.J, Ovsenek N, Bharadwaj L., (2003). Troglitazone reduces heat shock protein 70 content in primary hepatocytes by a ubiquitin proteasome independent mechanism. Pharmacological Research 48:119-127.

Book Chapters
Bharadwaj, L., Machibroda, R., (2009) Case Study: Saskatoon Rehabilitates its’ South Downtown Riverbank Area. Accepted for publication November, 2008. In: The Story of Brown Fields and Smart Growth in Kingston Ontario: From Contamination to Revitalization. Publisher: Classroom Complete Press, Toronto,Ontario.

Bharadwaj, L., (2009) Cardiac Toxicology: In General and Applied Toxicology (GAT), 3rd Edition. Editors: Drs. Bryan Ballantyne, Timothy Marrs and Tore Syversen. Published by: John Wiley & Sons, Ltd., The Atrium, Southern Gate, Chichester, West Sussex, PO19 8SQ, United Kingdom.

Bharadwaj, L. (2006). Drinking Water Contaminants and Human Health. In Velma I Grover (Ed), Water: Global Common and Global Problems (pp. 169-189). Enfield, NH, USA: Science Publisher.

Interview with Integrative Medicine Insights editorial board member Dr Merrijoy Kelner

This interview is with Integrative Medicine Insights editorial board member Dr Merrijoy Kelner. Integrative Medicine Insights is an open access journal published by Libertas Academica.

Editor in Chief Dr Steven Gurgevich has recently issued a call for papers.

What is the primary focus of your research?

Since my mandatory retirement in 1963, I have focused my research on Complementary and Alternative Medicine (CAM). This work evolved from my earlier research on chiropractors in the 1970's. Since retirement I have worked closely with Bev Wellman. We first looked at the patients who use a variety of CAM therapies and then turned our attention to the ways in which the CAM occupations are striving to become legitimate health care professionals in the Canadian system. Most recently we are examining the issues related to the integration of conventional medical care with CAM and I am now spearheading an international study of integrative care with scholars from Italy, Israel, the UK and the USA.

What are the most exciting developments arising from current research in your area?

In 1997 we published one of the first systematic profiles of patients who use CAM therapies. In the same year we also published an article that demonstrated that users of CAM do not give up their allopathic doctors incorporate CAM therapies into their overall health care.
In 1998 I organized the first international social science conference on CAM. One outcome of this was an edited book: "Complementary and Alternative Medicine: Challenge and Change" (Kelner Wellman Pescosoldo and Saks,2000), which featured the work of the scholars attending the conference. Recently, 2007, we held a planning workshop on integrative health care attended by scholars from four different countries.

Who are your main collaborators? Please describe your work with them.

Professor Heather Boon from the School of Pharmacy and Professor Sandy Welsh from the Department of Sociology, both from the University of Toronto joined our team in 2001 and have been working with us ever since on planning, conducting, analyzing and writing up our research on CAM.

How did you come to be working in your research area?

I first became interested in this area of research when I was teaching social science perspectives to medical students at the U of T medical school. I recognized that their view of health care was limited only to medical care and decided to arrange a couple of lectures from leading chiropractors. We continued this arrangement for a few years and this led to an invitation from the president of the national chiropractic organization to me and my colleague Peter New to conduct a Canada wide study of the chiropractors and their patients. This was published as "Chiropractors: Do they Help? (Kelner, Hall and Coulter, 1980.

As a consequence of this earlier interest and the stimulus of similar work done by some of my graduate students, Wellman and I decided to concentrate on this field of research after my retirement. At the time it was not a popular area of study for social scientists but has since developed into a much more solid research field.


What do you think about the development of open access publishing? Have you published in an open access journal? What motivated you to do so?

It is an interesting and timely development but I have not personally availed myself of the opportunity to use it.

What articles and/or books have you published recently?

Soklaridis, S., Kelner, M.J., Love, R., and D. Cassidy. Forthcoming 2009. “Integrative Health Care in a Hospital Setting: Communication Patterns Between Complementary and Alternative Medicine (CAM) and Biomedical Practitioners.” Journal of Inter-professional Care.

Soklaridis, S., Kelner, M.J., Love, R., and D. Cassidy. 2009. “The Organizational Support Necessary for Integrative Health Care (IHC): A Clinic for Artists in a Hospital Setting.” Journal of Complementary and Integrative Medicine 6(1):Article 3. DOI:10.2202/1553-3840.1139 http://www.bepress.com/jcim/vo16/iss1/3.

Kelner, M.J., Wellman, B., Welsh, S. and H. Boon. 2006. “How Far Can Complementary and Alternative Medicine Go? The Cases of Chiropractic and Homeopathy.” Social Science and Medicine 63:2617-2627.

Kelly, M., Hardwick, K., Motitz, S., Kelner, M.J., Rickhi, B. and H. Quan. 2005. “Towards Integration: The Opinions of Health Policy Makers on Complementary and Alternative Medicine.” Evidence Based Integrative Medicine 2(2):79-86.

Further Information

Faculty Website

Interview with Clinical Medicine Insights: Reproductive Health editorial board member Dr Lior Lowenstein

This interview is with Clinical Medicine Insights: Reproductive Health editorial board member Dr Lior Lowenstein. Clinical Medicine Insights: Reproductive Health is an open access journal published by Libertas Academica.

Editor in Chief Dr Zeev Blumenfeld has recently issued a call for papers

What is the primary focus of your research?

1. Surgical outcomes after minimally invasive pelvic reconstructive surgery.
2. Evaluation of urinary urgency in women with overactive bladder syndrome.
3. Neurophysioloigic testing using electrodiagnosis in the genito-urinary tract of women with pelvic floor dysfunction.
4. Pain control in women undergoing gynecological surgery.

What are the most exciting developments arising from current research in your area?

The urgeometer is a new device for evaluation of urgency sensation at the time of urodynamics testing.


Who are your main collaborators? Please describe your work with them.

Loyola Medical Center Chicago, Il

How did you come to be working in your research area?

At the time of my residency in Ob\Gyn I rotated at the Neurourlogy unit at our medical center. After doing some more research with the female urologists at our institiute, I have decided to do a formal fellowship in the field of Urogynecologist. I did my training at Loyola with Dr Beuberk, Kenton, FitzGerald and Mueller.

What do you think about the development of open access publishing? Have you published in an open access journal? What motivated you to do so?

I did not have the chance yet to publish at an open access.


What articles and/or books have you published recently?

Lowenstein L, Kenton K, Brubaker L, Hatchett L,Arvizu R, Goldman K, Mueller E.R, FitzGerald MP. Evaluation of Urgency in Women, with a Validated Urgency Severity and Impact Questionnaire (USIQ). Int Urogynecol J Pelvic Floor Dysfunct. 2009;20(3):301-7.

Lowenstein L, Pham T, Abbasy S, Kenton K, Brubaker L, Mueller ER, Shott S, Vardi Y, Gruenwald I, Fitzgerald MP. Observations relating to urinary sensation during detrusor overactivity. Neurourology and Urodynamics. 2008. [Epub ahead of print]

Lowenstein L, Fitz A, Kenton K, FitzGerald MP, Mueller ER, Brubaker L. Transabdominal Uterosacral Suspension : Outcomes and Complications. American Journal of Obstetrics and Gynecology 2009 Mar 21. [Epub ahead of print]

Lowenstein L, Gamble , Deniseiko Sanses T, van Raalte H, Carberry C, Jakus S, Kambiss S, McAchran S, Pham T, Aschkenazi S, Hoskey K, Kenton K, Sexual function is related to body image perceptionin women with pelvic organ prolapsed. Journal of Sexual Medicine 2009

Wednesday, June 9, 2010

Interview with Clinical Medicine Insights: Trauma and Intensive Medicine editorial board member Dr Michael Y. Wang

This interview is with Clinical Medicine Insights: Trauma and Intensive Medicine editorial board member Dr Michael Y. Wang. Clinical Medicine Insights: Trauma and Intensive Medicine is an open access journal published by Libertas Academica.

Editor in Chief Dr Philip Stahel has recently issued a call for papers

What is the primary focus of your research?

Neurosurgery, Spinal cord injury, Spinal trauma, Spinal surgery, Neurointensive care

What are the most exciting developments arising from current research in your area?

Neuromonitoring, Advancements in spinal fixation and vertebral column repair, Neuroregeneration, Brain machine interfaces

Who are your main collaborators? Please describe your work with them.

Mechanical engineers, Epidemiologists, Cell biologists, Orthopedic surgeons

How did you come to be working in your research area?

Following specialty training, I found the areas of greatest and fastest technological advancements were in the fields of spine surgery and neurointensive care. The pace of change in the field has been rapid, and our patients have benefitted from the effects of translational research and developments in bioengineering.

What do you think about the development of open access publishing? Have you published in an open access journal? What motivated you to do so?

This is a manifestation of the democratization and flattenning of the world in general. The proliferation of technology (the internet) now allows for the dissemination and mutual communication of information between professionals (clinicians and scientists) and patients as well. This is likely to lead to an acceleration in the development and proliferation of new, productive ideas and concepts.

What articles and/or books have you published recently?

1. P Khoueir, MH Black, PF Crookes, HS Kaufman, N Katkhouda, & MY Wang. Prospective assessment of axial back pain before and after bariatric weight reduction surgery. Spine J, 2009.

2. ADO Levi, BA Green, MY Wang, T Brindle, S Vanni, G Casella, G Elhammady, JJ Jagid. Clinical application of modest hypothermia after spinal cord injury. J Neurotrauma, 2009;:407-415.

3. DJ Hoh, BL Hoh, AP Amar, & MY Wang. Shape memory alloys: Metallurgy, biocompatibility and biomechanics for neurosurgical applications. Submitted for publication in Neurosurgery, 2009;ONS199-214.

4. SS Dhall, MY Wang, PV Mummaneni. Clinical and radiographic comparison of mini-open transforaminal lumbar interbody fusion with open transforaminal lumbar interbody fusion in 42 patients with long-term follow-up. Journal of Neurosurgery: Spine, 2008;9:560-565.

5. MY Wang, DG Anderson, KA Poelstra, & SC Ludwig. Minimally invasive posterior fixation for spinal deformities. Neurosurgery, 2008;63:A197-A204.

6. P Khoueir, BC Oh, & MY Wang, Delayed post-traumatic spinal deformities: Diagnosis & management. Neurosurgery, 2008;63:A117-A124.

7. DJ Hoh, JB Elder, & MY Wang. Principles of growth modulation in the treatment of scoliotic deformities. Neurosurgery, 2008;63:A211-A221.

8. MY Wang, DH Kim, KA Kim. Correction of late traumatic thoracic and thoracolumbar kyphotic spinal deformities using posteriorly placed intervertebral distraction cages. Neurosurgery, 2008;62:ONS162-172.

9. MY Wang, SC Ludwig, DG Anderson, PV Mummaneni. Percutaneous iliac screw placement: Description of a new minimally invasive technique. Neurosurgical Focus, 2008;25(2-E17):1-5.

10. DM Benglis, JD Guest, MY Wang. The clinical feasibility of minimally invasive cervical laminoplasty. Neurosurgical Focus, 2008;25(2-E3):1-4.

11. P Khoueir, DJ Hoh, & MY Wang. Use of hinged rods for controlled osteoclastic correction of a fixed cervical kyphotic deformity in ankylosing spondylitis. Journal of Neurosurgery: Spine, 2008;8:579-583.

12. D Benglis, MY Wang, ADO Levi. A comprehensive review of the safety profile of bone morphogenetic proteins in spinal surgery. Neurosurgery, 2008;62:ONS423-431.

13. JB Elder, DJ Hoh, & MY Wang. Postoperative continuous paravertebral anesthetic infusion for pain control in lumbar spinal fusion surgery. Spine, 2008; 33(2): 210-218.

14. AA Khalessi, BC Oh, & MY Wang. Medical management in ankylosing spondylitis. Neurosurgical Focus, 2008; 24(1) E4.

15. AS Kanter, MY Wang, PV Mummaneni. An algorithm for the management of cervical spine fractures and deformity in patients with ankylosing spondylitis. Neurosurgical Focus, 2008; 24(1) E11.

16. DJ Hoh, P Khoueir, & MY Wang. Management of cervical deformity in ankylosing spondylitis. Neurosurgical Focus, 2008; 24(1) E9.

17. DJ Hoh, CY Liu, JCT Chen, PG Pagnini, C Yu, MY Wang, MLJ Apuzzo. Chained Lightning, Part III: Emerging technology, novel therapeutic strategies, and new energy modalities for radiosurgery. Neurosurgery, 2007; 61(6):1111-1130.

18. P Khoueir & MY Wang. Posterior dynamic stabilization as a salvage procedure for lumbar facet degeneration following total disc arthroplasty. Spine Arthroplasty Society (SAS) Journal, 2007; 1(4):143-146.

19. MY Wang. Cervical crossing laminar screws: Early clinical results and complications. Neurosurgery, 2007; 61(ONS-2):ONS311-316.

20. P Khoueir, BC Oh, DJ DiRisio, MY Wang. Multilevel anterior cervical fusion using a collagen-hydroxyapatite matrix with iliac crest bone marrow aspirate: An eighteen month follow-up study. Neurosurgery, 2007; 61(5):963-971.

21. DJ Hoh, CY Liu, JCT Chen, PG Pagnini, C Yu, MY Wang, MLJ Apuzzo. Chained Lightning, Part II: Neurosurgical principles, radiosurgical technology, and the manipulation of energy beam delivery. Neurosurgery, 2007; 61(2):433-446.

22. DJ Hoh, CY Liu, PG Pagnini, C Yu, MY Wang, MLJ Apuzzo. Chained Lightning, Part I: Exploitation of energy and radiobiological principles for therapeutic purposes. Neurosurgery, 2007; 61(1):14-28.

23. BC Oh, CY Liu, MY Wang, PG Pagnini, C Yu, MLJ Apuzzo. Stereotactic radiosurgery: Adjacent tissue injury and response after high-dose single fraction radiation: Part II-Strategies for therapeutic enhancement, brain injury mitigation, and brain injury repair. Neurosurgery, 2007; 60(5):799-814.

24. M McDonald, R Cooper, MY Wang. Use of computed tomography-single-photon emission computed tomography fusion for diagnosing painful facet arthropathy. Neurosurgical Focus, 2007; 22(1): E2.

25. P Khoueir, KA Kim, & MY Wang. Classification of posterior dynamic stabilization devices. Neurosurgical Focus, 2007; 22(1):E3.

26. KA Kim, M McDonald, JHT Pik., P Khoueir, MY Wang. Dynamic interspinous spacer technology for posterior stabilization: case-control study on the safety, sagittal angulation, and pain outcome at 1-year follow-up evaluation. Neurosurgical Focus, 2007; 22(1):E7.

27. MY Wang, & SH Berven. Operative Nuances: Lumbar pedicle subtraction osteotomy. Operative Neurosurgery, 2007; 60(ONS-1):ONS140-ONS146.

28. BC Oh, PG Pagnini, MY Wang, CY Liu, PE Kim, C Yu, MLJ Apuzzo. Stereotactic radiosurgery: Adjacent tissue injury and response after high-dose single fraction radiation: Part I-Histology, imaging, and molecular events. Neurosurgery, 2007; 60(1):31-45.

29. KA Kim & MY Wang. MRI-based morphologic predictors of SPECT positive facet arthropathy in patients with axial back pain. Neurosurgery, 2006;59(1):147-156.

30. MY Wang. C2 crossing laminar screws: Cadaveric morphometric analysis. Neurosurgery, 2006;59(1):ONS84-88.

31. YD Marquez, MY Wang, CY Liu. Cellular signaling in neural stem cells: implications for restorative surgery. Neurosurgical Focus, 2005; 19(3):1-4.

32. MY Wang & ADO Levi. Minimally Invasive Lateral Mass Screw Fixation in the Cervical Spine: Initial Clinical Experience with Long-Term Follow-up. Neurosurgery, 2006;58(5):907-912.

33. SH Kitchel, MY Wang, CL Lauryssen. Techniques for aspirating bone marrow for use in spinal surgery. Neurosurgery, 2005;57(4):ONS286-289.

34. KA Kim, MY Wang, SA McNatt, G Pinsky, CY Liu, SL Giannotta, MLJ Apuzzo. Vector analysis correlating bullet trajectory to outcome after civilian through-and-through gunshot wound to the head: using imaging cues to predict fatal outcome. Neurosurgery. 2005;57(4):737-746.

35. MY Wang & CY Liu. Resorbable polylactic acid interbody spacers and vertebral autograft for anterior cervical discectomy and fusion. Neurosurgery,2005;57(1):135-140.

36. MY Wang, C Leung, & A Casey. Cervical arthroplasty with the Bryan Cervical Disc. Operative Neurosurgery, 2005;56(1):58-65.

37. MC Lee, MY Wang, RG Fessler, J Liauw, D Kim. Instrumentation in patients with spinal infection. Neurosurgical Focus, 2004; 17(6).

38. C Yu, W Main, D Taylor, G Kuduvalli, MLJ Apuzzo, JR Adler, MY Wang. An anthropomorphic phantom study of the accuracy of Cyberknife spinal radiosurgery. Neurosurgery 2004; 55(5):1138-1149.

39. MY Wang, S Shah, BA Green. Clinical outcomes following cervical laminoplasty for 204 patients with cervical spondylotic myelopathy. Surgical Neurology 2004; 62:487-493.

40. Liu CY, MY Wang, MLJ Apuzzo. The evolution and future of minimalism in neurological surgery. Childs Nerv Sys 2004;20:783-789.

41. Liu CY, MY Wang, MLJ Apuzzo. The physics of image formation in the neuroendoscope. Childs Nerv Sys 2004;20:777-782.

42. MY Wang, DJ Hoh, SP Leary, P Griffith, JG McComb. High rates of neurological improvement following severe traumatic pediatric spinal cord injury. Spine 2004;29:1493-1497.

43. MY Wang, Samudrala S. Cadaveric morphometric analysis for atlantal lateral mass screw placement. Neurosurgery 2004;54(6):1436-1440.

44. MY Wang, KA Kim, CY Liu, P Kim, MLJ Apuzzo. Reliability of 3-D fluoroscopy for detecting pedicle violations in the thoracic and lumbar spine. Neurosurgery 2004;54(5):1138-1143.

45. DJ Hart, MY Wang, P Griffith, JG McComb. Pediatric sacral fractures. Spine 2004;29:667-670.

46. MY Wang, BA Green. Operative Nuances: Open-door cervical expansile laminoplasty. Neurosurgery 2004;54(1):119-124.

47. ML Levy, MY Wang, K Yoo, H Aryan, H Meltzer. Keyhole microsurgical fenestration of middle fossa arachnoid cysts. Neurosurgery 2003;53(5):1138-1145.

48. MY Wang, BA Green. Laminoplasty for the treatment of failed anterior cervical spine surgery. Neurosurgical Focus 2003;15(E7):1-4.

49. MY Wang, ADO Levi, E Vitarbo, BA Green. Adjacent segment degeneration: An unusual complication following cervical expansile laminoplasty. Neurosurgery 2003;53(2):770-773.

50. MY Wang, ADO Levi, BA Green. Intradural spinal arachnoid cysts in adults. Surgical Neurology 2003;60(1):49-55.

51. MY Wang, A Sherman, S Vanni, ADO Levi, BA Green. Lumbar stenosis surgery in the fourth quartile of life. Neurosurgical Focus 2003;14(2): Article 7 pp 1-4.

52. MY Wang, C Prusmack, BA Green, ADO Levi. Minimally invasive lateral mass screws for the treatment of cervical facet fracture dislocations. Neurosurgery 2003;52(2):444-448.

53. MY Wang, BA Green, E Cascarella, M Baskaya, ADO Levi, JD Guest. Minimally invasive cervical expansile laminoplasty: An initial cadaveric study. Neurosurgery 2003;52(2)370-373.

54. MY Wang, P Wallace, JP Gruen. Brain death documentation: Analysis and issues. Neurosurgery 2002;51(3):731-6.

55. MY Wang, ADO Levi, SN Shah, BA Green. Mesh reconstruction of the anterior iliac crest after bone harvesting reduces early postoperative pain following anterior cervical fusion surgery. Neurosurgery 2002;51(2):413-6.

56. MY Wang, ADO Levi. C2 ganglionectomy for medically refractory occipital neuralgia. Neurosurgical Focus 2002:12(14).

57. MY Wang, KA Kim, PM Griffith, S Summers, JG McComb, ML Levy, GH Mahour. Injuries from pediatric Falls: An analysis of 729 cases. Journal of Pediatric Surgery 2001:36(10):1528-1534.

58. MY Wang, JK Armstrong, TC Fisher, HJ Meiselman, GJ McComb, ML Levy. Pluronic surfactant polymer as a new bone hemostatic agent that does not inhibit osteogenesis. Neurosurgery 2001;49(4):962-968.

59. TL Harpold, MY Wang, JG McComb, HL MonForte, ML Levy, JF Reinisch. Maternal lung adenocarcinoma metastatic to the scalp of a fetus: case report. Pediatric Neurosurgery2001;35(1):39-42.

60. AP Amar, MY Wang, DW Larsen, GP Teitelbaum. Cervical epidural catheterization via a lumbar puncture. Neurosurgery 2001;48(5):1183-1187.

61. MY Wang, S Lavine, H Soukasian, R Tabrizi, ML Levy, S Giannotta. Primary Care Residents’ Knowledge of “Brain Attack” and Carotid Endarterectomy. Neurosurgery 2001;48(5):1109-1117.

62. MY Wang, R Tabrizi, S Giannotta. Delays in referral of patients with subarachnoid hemorrhage. Journal of Stroke & Cerebrovascular Disease 2000;9(6):282-286.

63. MY Wang, P Griffith, J Sterling, JG McComb, M Levy. A prospective population-based study of pediatric trauma patients with mild alterations in consciousness (Glasgow Coma Score of 13-14). Neurosurgery 2000;46(5):1093-1099.

64. MY Wang, G Teitelbaum, WJ Loskota, D Eng, F Albuquerque, JP Gruen. Brachial Plexus Catheter Reservoir for the Treatment of Upper Extremity Cancer Pain. Neurosurgery 2000;46(4):1009-1012.

65. MY Wang, S Lavine, R Mimran, A Mohit, S Giannotta Carotid Stenosis in a multiethnic population. Journal of Stroke & Cerebrovasc Disease 2000;9(2):64-69.

66. MY Wang, R Mimran, S Lavine, S Giannotta. Posterior circulation aneurysms in a multi-ethnic population. Journal of Stroke & Cerebrovascular Disease 2000; 9(1):31-35.

67. K A Kim, MY Wang, P Griffith, S Summers, M Levy. An analysis of pediatric head injury from falls. Neurosurgical Focus January 15, 2000:8(1).

68. MY Wang, M Levy, M Mittler, C Liu, S Johnston, JG McComb. A Prospective analysis of the use of octylcyanoacrylate tissue adhesive for wound closure in pediatric neurosurgery. Pediatric Neurosurgery 1999; 30:186-188.

69. MY Wang, GK Steinberg. Rapid and near-complete resolution of moyamoya vessels in a moyamoya patient treated with superficial temporal artery to middle cerebral artery bypass. Pediatric Neurosurgery 1996; 24(3):145-50.

70. EN Unemori, N Ehsani, MY Wang, S Lee, JS McGuire, EP Amento. Interleukin-1 and transforming growth factor-alpha: Synergistic stimulation of metalloproteinases, PGE-2, and proliferation in human fibroblasts. Exp Cell Res Feb 1994: 210(2): 166-71.

Interview with Environmental Health Insights editorial board member Dr Lars Carlsen

This interview is with Environmental Health Insights editorial board member Dr Lars Carlsen. Environmental Health Insights is an open access journal published by Libertas Academica.

Editor in Chief Dr Timothy Kelley has recently issued a call for papers

What is the primary focus of your research?

Environmental and human health impact of xenobiotics and their transformation products.

Development and application of model tools, such as structure-activity relationships and ranking techniques as decision support tools for the evaluation and prioritization of chemicals and polluted soils and waters to be carried out by industry and regulatory bodies.

Development and application of tools to prioritize the possible action by industry and regulatory bodies in the environmental area, including studies on how these tools can be integrated in environmental management.

What are the most exciting developments arising from current research in your area?

In our current studies on the possible negative influence on the environment and human health as a result of space activities at the Baikonur Cosmodrome in Kazakhstan we face some rather interesting features looking at the combined effects involving both the primary pollutant (the rocket fuel) as well as the transformation products. It appears that the combination of QSAR modelling with partial order ranking (POR) methodologies and Formal Concept Analysis (FCA) is a rather strong tool in assessing chemicals as well as prioritizing polluted sites.


Who are your main collaborators? Please describe your work with them.

For the time being my main collaborators are the Center of Physical and Chemical Methods and Analysis (CPCMA) at the al-Farabi Kazakh National University. The main focus of the current research is the possible negative influence on the environment and human health as a result of space activities at the Baikonur Cosmodrome in Kazakhstan. Further collaborations are with Leibniz - Institute of Freshwater Ecology and Inland Fisheries where I am involved in the further development of the use of partial order ranking methodologies.

How did you come to be working in your research area?

The nature of my current research is simply a result of the development over the years.

What do you think about the development of open access publishing? Have you published in an open access journal? What motivated you to do so?

I have published in open access journals and I like the idea. Not everyone has access to the "old" journals - either in printed version or online. The motivation is obviously to get to a broader audience, but the problem is that in most cases publishing in open access journals are far too expensive.

What articles and/or books have you published recently?

The last five papers we have published are:

289) A QSAR/QSTR study on the human health impact by the rocket fuel 1,1-dimethyl hydrazine and its transformation products Lars Carlsen, Bulat N. Kenessov and Svetlana Ye. Batyrbekova Environ.Toxicol.Pharmacol. 27 (2009) 415-423

Fate modelling of DEHP in Roskilde Fjord, Denmark Patrik Fauser, Jørgen Vikelsøe, Peter B. Sørensen and Lars Carlsen Environ.Model.Assess 14 (2009) 209-220

The interplay between QSAR/QSPR studies and Partial Order Ranking and Formal Concept Analyses Lars Carlsen Internat.J.Mol.Sci., 10 (2009) 1628-1657

Partial Order Ranking as a Tool in Environmental Impact Assessment. PAH and PCB pollution of the river Main as an illustrative example. Lars Carlsen and Rainer Brüggemann
In: Environmental Impact Assessments, George T. Halley and Yeram T. Fridian, eds., Nova Science Publishers, Inc., 2009, pp. 335 - 354 ( ISBN 978-1-60692-667-3)

Трансформация несимметричного диметилгидразина в водных экстрактах почв (Transforation of asymmetrical dimethyl hydrazine in water extracts of soil M.B.Alimzhanova, B.N.Kenesov, S.E.Batyrbekova, L. Carlsen and M.K.Nauryzbaev Izvestiya of NAS of RK. Chemical series. Vol.373, No.1. P.87-92

Further Information

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