Friday, November 21, 2014

Published This Week (17th - 21st November)

We are pleased to announce the publication of the following peer reviewed papers. Sign up to receive email alerts to receive immediate notification of new papers.

Analytical Chemistry Insights
A Study of Method Development, Validation, and Forced Degradation for Simultaneous Quantification of Paracetamol and Ibuprofen in Pharmaceutical Dosage Form by RP-HPLC Method


Cancer Informatics
Type I Error Control for Tree Classification

A Bayesian Framework to Improve MicroRNA Target Prediction by Incorporating External Information

Clinical Medicine Insights: Case Reports
Acute Iodine Toxicity From a Suspected Oral Methamphetamine Ingestion

Switching from Nitrate Therapy to Ranolazine in Patients with Coronary Artery Disease Receiving Phosphodiesterase Type-5 Inhibitors for Erectile Dysfunction

Clinical Medicine Insights: Trauma and Intensive Medicine
The Management of Pediatric Polytrauma: Review

Complex Tibial Fractures: Tips and Tricks for Intramedullary Nail Fixation

Environmental Health Insights
Magnetic Resonance Imaging of Graded Skeletal Muscle Injury in Live Rats

Health Services Insights
The Lebanese Society of Cardiology: Plans and Perspectives, Navigating Against Contrary Winds and Progressing Against All Odds

Lymphoma and Chronic Lymphocytic Leukemias
The Role of Functional Imaging in Lymphoma: Current Controversies and Future Directions 

Microbiology Insights
Genetic Diversity and Allelic Frequency of Glutamate-Rich Protein (GLURP) in Plasmodium falciparum Isolates from Sub-Saharan Africa

 

Thursday, November 20, 2014

Magdalena Kegel Discusses How The Kynurenine Pathway Affects Mental Health

Severe psychiatric disorders, such as schizophrenia, bipolar disorder and depression, are ruining the lives of millions of people worldwide. The kynurenine [kæjnurenin] pathway, unknown to most and difficult to pronounce, is increasingly being viewed as an important component in a multitude of physiological and pathological functions, including psychiatric disorders. So what is this pathway and how can it affect the way we feel and perceive the world surrounding us?

The kynurenine pathway, so called because of the sequential breakdown of compounds collectively known as kynurenines, stems from the dietary amino acid tryptophan. Tryptophan is mostly known as the compound initiating the production of the neurotransmitter serotonin, which is believed to play an important role in depression. Most of the tryptophan in the human body is however not converted to serotonin. As much as 95% of all tryptophan is utilized in the kynurenine pathway, giving rise to a number of compounds with the ability to alter the signaling of neurons in the brain. The pathway is divided into two main arms, branching off from the compound kynurenine. Kynurenic acid (KYNA) is the sole product of one branch. The other branch leads to a number of substances, among them the important quinolinic acid (QUIN). Our understanding is that the flow of kynurenine into one of these branches is increased in a number of disorders.

In the context of psychotic disorders, the compound KYNA has been most extensively studied. KYNA is found in elevated concentrations in patients with schizophrenia and bipolar disorder. Using experiments where researchers either increase or decrease the levels of KYNA in the brain of rodents, it has been shown that KYNA modulates the signaling by several important neurotransmitters in the brain, one of them being dopamine. Dopamine is in turn believed to underlie the development of both psychotic and manic symptoms as observed in schizophrenia and bipolar disorder. Increased levels of KYNA also decreases the levels of glutamate, another neurotransmitter with defect signaling in psychotic disorders. Furthermore, it produces cognitive deficits, such as working memory problems, in experimental animals. Cognition is under the control of both glutamate and acetylcholine neurotransmission, and the receptors for these neurotransmitters are the direct targets of KYNA in the brain. Compromised cognitive function in schizophrenia and bipolar disorder is considered to be a core feature of these disorders, and often presents a large barrier towards normal societal functioning for these patients.
Another compound of the kynurenine pathway, QUIN, is found in normal concentrations in patients with schizophrenia but is believed to play a role in unipolar depression. In two studies investigating patients who attempted suicide, of which approximately half the patients were depressed, researchers found elevated levels of QUIN.

QUIN is a known neurotoxin, involved in tissue destruction following traumatic brain injury or oxygen deprivation. As such, it has been implicated in a number of neurodegenerative disorders. Depression is a psychiatric disorder associated with reduced volume of brain tissue, specifically in regions associated with memory, as well as memory impairment. It is being investigated whether the increased levels of QUIN might cause the reduction in neural tissue and contribute to depressive symptoms. Drugs targeting the kynurenine pathway might hence provide novel opportunities for drug treatment in severe psychiatric disorders, specifically targeting symptoms not responding to the treatment available today in a satisfactory manner. Further research on the role of the kynurenine pathway in psychiatric disorders is therefore of utmost importance to all the people suffering psychiatric disorders today.

Magdalena Kegel is author of the recently published paper, Imbalanced kynurenine pathway in schizophrenia, available for download now in International Journal of Tryptophan Research.

Monday, November 17, 2014

Interview with Mrs Alyssa Brooks

This author interview is by Alyssa Brooks, of the National Institutes of Health. Mrs Brooks' full paper, Sleep Disturbances in Individuals with Alcohol-Related Disorders: A Review of Cognitive-Behavioral Therapy for Insomnia (CBT-I) and Associated Non-Pharmacological Therapies, is available for download in Substance Abuse: Research and Treatment.

First please summarise for readers the content of your article.
Our recently-published literature review examines the effectiveness of cognitive behavioural therapy for insomnia (CBT-I) and other behavioural interventions for those with alcohol-related disorders. Six articles were systematically reviewed and we discovered that the majority of studies demonstrated significant improvements in sleep efficiency among the treatment groups. A secondary goal of this review was to summarize various methods of behavioural / non-pharmacologic sleep intervention delivery, including therapy delivered by landline/smartphone or computer.

How did you come to be involved in your area of study?
I have been involved in alcohol research since I was an undergraduate at the Penn State Prevention Research Center. When I started graduate school at the University of Maryland, I simultaneously started working at the National Institutes of Health Clinical Center (NIH CC) as a pre-doctoral intramural research fellow. Through working on multiple projects examining health behaviour and chronic care management in diverse and vulnerable populations, I was constantly reminded of the concept of holistic and patient-centred care. Like other individuals with chronic and progressive diseases, alcoholics often struggle with a range of co-morbid conditions. At the NIH, I worked on a project examining the prevalence of sleep disturbances among alcoholics undergoing inpatient rehabilitation. Although sleep was not originally one of my research interests, I am learning the importance of quality sleep for relapse prevention and overall quality of life among alcoholics. This realization inspired my dissertation study, which utilizes mixed-methods to examine sleep disturbances and their role in relapse among recovering alcoholics during both the inpatient and outpatient phases of treatment.

What was previously known about the topic of your article?
Alcohol consumption and sleep disturbances frequently co-occur, and sleep disturbances are often associated with relapse. The evidence for CBT-I as an effective means for improving sleep duration and quality is building, but little research has been done specifically among alcoholics.

How has your work in this area advanced understanding of the topic?
This paper was meant to start the conversation on tailoring evidence-based sleep interventions to alcohol-dependent individuals. The unique needs of recovering are immensely important to identify, understand, and work with when designing interventions that are not only evidence-based but feasible and acceptable to the target population.

What do you regard as being the most important aspect of the results reported in the article?
Non-pharmacological sleep interventions may be effective, but should be tailored to recovering alcoholics. Thorough mixed-methods research is needed to inform these future interventions.

Alyssa Brooks' LinkedIn profile

Friday, November 14, 2014

Published Recently (10th November – 14th November)

We are pleased to announce the publication of the following peer reviewed papers. Sign up to receive email alerts to receive immediate notification of new papers.

Biochemistry Insights
Withaferin A Inhibits STAT3 and Induces Tumor Cell Death in Neuroblastoma and Multiple Myeloma

Bone and Tissue Regeneration Insights
Nanotechnology in the Regeneration of Complex Tissues

Cancer Informatics
Conducting Retrospective Ontological Clinical Trials in ICD-9-CM in the Age of ICD-10-CM

Clinical Medicine Insights: Cardiology
Stroke Awareness in Luxemburg: Deficit Concerning Symptoms and Risk Factors

Atherosclerosis As a Possible Extrahepatic Manifestation of Chronic Hepatitis C Virus Infection

Transcatheter Aortic Valve Implantation (TAVI): Is it Time for This Intervention to be applied in a Lower Risk Population?

Environmental Health Insights
Generation of Reactive Oxygen Species from Silicon Nanowires

Temporal and Spatial Distribution of Tick-Borne Disease Cases among Humans and Canines in Illinois (2000-2009)

Drug Target Insights
The Expression of Serum Antibodies Against Gonadotropin-releasing Hormone (GnRH1), Progonadoliberin-2, Luteinizing Hormone (LH), and Related Receptors in Patients with Gastrointestinal Dysfunction or Diabetes Mellitus

Immunology and Immunogenetics Insights
Cellular Responses to Cytosolic Double-stranded RNA-The Role of the Inflammasome

Journal of Medical Education and Curricular Development
A Pilot Study on the Use of Lecture Tools to Enhance the Teaching of Pharmacokinetics and Pharmacodynamics

Magnetic Resonance Insights
Damage to the Optic Chiasm in Myelin Oligodendrocyte Glycoprotein-Experimental Autoimmune Encephalomyelitis Mice

Microbiology Insights
Evaluative Profiling of Arsenic Sensing and Regulatory Systems in the Human Microbiome Project Genomes

Friday, November 7, 2014

Published Recently (27th October - 7th November)

We are pleased to announce the publication of the following peer reviewed papers. Sign up to receive email alerts to receive immediate notification of new papers.

Biomarkers in Cancer
A Standardized and Reproducible Urine Preparation Protocol for Cancer Biomarkers Discovery

Cancer Informatics
A Pan-Cancer Modular Regulatory Network Analysis to Identify Common and Cancer-Specific Network Components

Propensity Score Method for Partially Matched Omics Studies

A Novel Subset of Human Tumors That Simultaneously Overexpress Multiple E2F-responsive Genes Found in Breast, Ovarian, and Prostate Cancers

Predicting Cancer Prognosis Using Functional Genomics Data Sets

In Silico Prediction of Synthetic Lethality by Meta-Analysis of Genetic Interactions, Functions, and Pathways in Yeast and Human Cancer

Clinical Medicine Insights: Cardiology
Unusual Case of a Free-floating Ball Thrombus with Preserved Attachment to the Left Atrial Appendage Causing Recurrent Obstruction of the Left Ventricular Outflow Tract

Clinical Medicine Insights: Gastroenterology
Bupivacaine Lozenge Compared with Lidocaine Spray as Topical Pharyngeal Anesthetic before Unsedated Upper Gastrointestinal Endoscopy: A Randomized, Controlled Trial

Clinical Medicine Insights: Pediatrics
Safety and Tolerance Evaluation of Milk Fat Globule Membrane-Enriched Infant Formulas: A Randomized Controlled Multicenter Non-Inferiority Trial in Healthy Term Infants

Clinical Medicine Insights: Therapeutics
Perampanel for the Control of Drug-Resistant Partial-Onset Seizures in Patients 12 years and Older

Environmental Health Insights
Insights into Ebola and Other Emerging and Re-emerging Infectious Disease Risks

Investigations of Koutango Virus Infectivity and Dissemination Dynamics in Aedes aegypti Mosquitoes

Economic Evidence on the Health Impacts of Climate Change in Europe

Evolutionary Bioinformatics
Evolutionary Analysis and Prediction of Peptide Vaccine Candidates for Foot-and-Mouth-Disease Virus Types A and O in Bangladesh

Integrative Medicine Insights
Randomized Trial of Hypnosis as a Pain and Symptom Management Strategy in Adults with Sickle Cell Disease

Journal of Medical Education and Curricular Development
Evaluation of the Assessment Plan for Undergraduate Clerkship in Obstetrics and Gynecology, King Abdulaziz University

Substance Abuse: Research and Treatment
Feasibility of Applying the Life History Calendar in a Population of Chronic Opioid Users to Identify Patterns of Drug Use and Addiction Treatment

Thursday, November 6, 2014

Four Journals Now Indexed in DOAJ Database

We have recently had a number of our journals now indexed in the popular DOAJ (Directory of Open Access Journals) database.

The journals have passed through an extensive evaluation process prior to approval. DOAJ has thoroughly evaluated the journal's editorial and production processes and has confirmed that the journal is compliant with an extensive list of criteria.

The journals indexed with DOAJ are;

  • Journal of Genomes and Exomes

  • Healthy Aging & Clinical Care in the Elderly

  • Health Services Insights

  • Journal of Experimental Neuroscience

More information about the evaluation process and the standards that journals must meet for inclusion can be found on the DOAJ website.

Tuesday, November 4, 2014

Dr Abdul Hameed discusses Myeloma Bone Disease

Multiple myeloma (MM) is a type of blood cancer and is categorized as a plasma cell disorder. Plasma cells are one type of white blood cells involved in body defense (protecting us from infections). In a normal person, these cells produce antibodies (proteins which kill bacteria/germs). In MM, one type of these plasma cells (clonal), are produced in large number and they keep on multiplying out of control. The main bulk of plasma cells are found in bone marrow. The majority of MM patients suffer from bone damage because of this.

In healthy individuals there is a balance between the bone destruction and formation. Bone resorbing cells (osteoclasts) break old bone and bone formation cells (Osteoblasts) start repairing these areas. This balance is lost in MM. Plasma cells produce certain chemicals (cytokines) which in turn stimulate Osteoclasts and suppress Osteoblasts. Thus, in MM there is more bone breakdown than formation. This results in the development of bone disease in MM. Bones become weaker and break easily (fractures).

Due to bone disease, patients suffer from pain, reduced mobility and poor quality of life.

Plain X-Rays are routinely used for the detection of myeloma bone disease(MBD). Newer imaging modalities such as MRI/ Positron emission tomography CT are useful are better than X-rays for the evaluation of MBD. In certain circumstances these imaging tools are preferable when detecting MBD. For example MRI is better than plain x-rays for detection of spine lesions.

Management of MBD involves control of systemic disease. Patients should be started on anti-myeloma treatment according to standard recommendations. In addition, patients need regular (on a monthly basis) injections of bisphosphonates (Aredia/Zometa- types of bone strengtheners). Bisphosphonates reduce bone destruction by inhibition of Osteoclasts. These agents are also helpful in controlling pain and reducing the risk of fractures. Bisphosphonates are given for a couple of years (provided disease remains in remission).

However, long term use may result in certain serious side effects of these agents including damage to kidney and jaw bones (Osteonecrosis of jaw) which is why patients on this treatment should remain under close observation for complications.

Invasive dental procedures should be avoided while being on bisphosphonates. If any dental workup is required, then the treating Hematologist / Oncologist and Dentist should be on board. Bisphosphonates should be stopped and restarted at least 90 days before and post procedure, respectively.

Apart from bisphosphonates, there are some other treatment methods used to manage MBD. These include spine strengthening procedures such as vertebroplasty / Kyphoplasty and even surgical intervention may be required to deal with fractures. In those patients where pain is a major issue, advice from pain management team should also be sought.

With the addition of novel agents in the treatment of MM, patients are living longer. Thus, there is a need to address MBD issues aggressively in order to improve the quality of life in these patients.

There is now a better understanding of the mechanisms behind the development of MBD and new targeted therapies are in clinical trials to treat this morbid condition. The future looks promising.  

Dr Abdul Hameed from Shaukat Khanum Memorial Cancer Hospital & Research Centre in Lahore, Pakistan, is author of the recently published paper Bone Disease in Multiple Myeloma: Pathophysiology and Management, available for download now in Cancer Growth and Metastasis.

Friday, October 31, 2014

Published During October

We are pleased to announce the publication of the following peer reviewed papers.  Sign up to receive email alerts to receive immediate notification of new papers.

Advances in Tumor Virology
A Potential Linkage Between the JC and BK Polyomaviruses and Brain and Urinary Tract Tumors: A Review of the Literature

Bioinformatics and Biology Insights
Computational Methods for CLIP-seq Data Processing   

Biomarker Insights
Decreased Mitogen Inducible Gene 6 (MIG-6) Associated with Symptom Severity in Children with Autism

Bone and Tissue Regeneration Insights
A Review of the Pathogenesis of Osteoarthritis and the Use of Intra-articular Platelet Therapy for Joint Disease in Animals and Humans

Characterization of Human Anulus Fibrosus– and Nucleus Pulposus–Derived Cells During Monolayer Expansion and in Hydrogel Cultures

Breast Cancer: Basic and Clinical Research
RAD51B Activity and Cell Cycle Regulation in Response to DNA Damage in Breast Cancer Cell Lines

Hereditary Breast Cancer: Clinical, Pathological and Molecular Characteristics

Update on Adjuvant Chemotherapy for Early Breast Cancer

Cancer Informatics
Combined Benefit of Prediction and Treatment: A Criterion for Evaluating Clinical Prediction Models

Bayesian Disease Classification Using Copy Number Data

Introductory Editorial: Computational Advances in Cancer Informatics (A)

Inferring Aberrant Signal Transduction Pathways in Ovarian Cancer from TCGA Data

Optimization of Network Topology in Computer-Aided Detection Schemes Using Phased Searching with NEAT in a Time-Scaled Framework

Mining Cancer-Specific Disease Comorbidities from a Large Observational Health Database

Text Mining in Cancer Gene and Pathway Prioritization

Modeling Signal Transduction from Protein Phosphorylation to Gene Expression

CSNK1A1 and Gli2 as Novel Targets Identified Through an Integrative Analysis of Gene Expression Data, Protein-Protein Interaction and Pathways Networks in Glioblastoma Tumors: Can These Two Be Antagonistic Proteins?

RNAseqPS: A Web Tool for Estimating Sample Size and Power for RNAseq Experiment

Inferring the Effects of Honokiol on the Notch Signaling Pathway in SW480 Colon Cancer Cells

Feasibility and Implementation of a Literature Information Management System for Human Papillomavirus in Head and Neck Cancers with Imaging

Exploiting Literature-derived Knowledge and Semantics to Identify Potential Prostate Cancer Drugs

Prediction of MicroRNA Precursors Using Parsimonious Feature Sets

Disease Biomarker Query from RNA-Seq Data

Integrated DNA Copy Number and Gene Expression Regulatory Network Analysis of Non-small Cell Lung Cancer Metastasis

Toolbox for Mobile-Element Insertion Detection on Cancer Genomes

Mapping Splicing Quantitative Trait Loci in RNA-Seq

TEGS-CN: A Statistical Method for Pathway Analysis of Genome-wide Copy Number Profile

Unsupervised Outlier Profile Analysis

CORM: An R Package Implementing the Clustering of Regression Models Method for Gene Clustering

Profiling the microRNA Expression in Human iPS and iPS-derived Retinal Pigment Epithelium

Master Regulators, Regulatory Networks, and Pathways of Glioblastoma Subtypes

Network-based Prediction of Cancer under Genetic Storm

Quality Control for RNA-Seq (QuaCRS): An Integrated Quality Control Pipeline

Automated Recommendation for Cervical Cancer Screening and Surveillance

Network-Based Identification of Biomarkers Coexpressed with Multiple Pathways

StickWRLD as an Interactive Visual Pre-Filter for Canceromics-Centric Expression Quantitative Trait Locus Dataz  

A Comprehensive Comparison of Normalization Methods for Loading Control and Variance Stabilization of Reverse-Phase Protein Array Data

Network Analysis of Cancer-focused Association Network Reveals Distinct Network Association Patterns

Co-expression Network Analysis of Human lncRNAs and Cancer Genes

The Axis of Progression of Disease

eMBI: Boosting Gene Expression-based Clustering for Cancer Subtypes

Classification of Images Acquired with Colposcopy Using Artificial Neural Networks

Learning Dysregulated Pathways in Cancers from Differential Variability Analysis

A Pan-Cancer Modular Regulatory Network Analysis to Identify Common and Cancer-Specific Network Components

Propensity Score Method for Partially Matched Omics Studies

Clinical Medicine Insights: Cardiology
Impact of D-Dimers on the Differential Diagnosis of Acute Chest Pain: Current Aspects Besides the Widely Known

The Association of Pre-Existing Left Atrial Fibrosis with Clinical Variables in Patients Referred for Catheter Ablation of Atrial Fibrillation

Diagnosis and Management of Valvular Aortic Stenosis

Clinical Medicine Insights: Case Reports
Double Hit Lymphoma – a Case of Unusual Response After Sequential Aggressive Chemotherapy and Review of the Literature

Late-Onset Screw Migration into Iliac Vessels 21 years after Hip Arthrodesis

Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine
Perceptions of Received Information, Social Support, and Coping in Patients with Pulmonary Arterial Hypertension or Chronic Thromboembolic Pulmonary Hypertension     

Clinical Medicine Insights: Gastroenterology
Diabetic Ketoacidosis-induced Hypertriglyceridemic Acute Pancreatitis Treated with Plasmapheresis—Recipe for Biochemical Disaster Management 

Bupivacaine Lozenge Compared with Lidocaine Spray as Topical Pharyngeal Anesthetic before Unsedated Upper Gastrointestinal Endoscopy: A Randomized, Controlled Trial 

Clinical Medicine Insights: Reproductive Health
Individualized Treatment from Theory to Practice: The Private Case of Adding LH during GnRH Antagonist-based Stimulation Protocol

Environmental Health Insights
Identification of Larvicide-Resistant Catch Basins from Three Years of Larvicide Trials in a Suburb of Chicago, IL

Volitional Weight-Lifting in Rats Promotes Adaptation via Performance and Muscle Morphology prior to Gains in Muscle Mass

Evaluation of the Pulmonary Toxicity of a Fume Generated from a Nickel-, Copper-Based Electrode to be Used as a Substitute in Stainless Steel Welding

Insights into Ebola and Other Emerging and Re-emerging Infectious Disease Risks

Investigations of Koutango Virus Infectivity and Dissemination Dynamics in Aedes aegypti Mosquitoes

Evolutionary Bioinformatics
A New Method for Motif Mining in Biological Networks

Comparative Study on Sequence–Structure–Function Relationship of the Human Short-chain Dehydrogenases/Reductases Protein Family

Cloning and Expression Profiling of the Polycomb Gene, Retinoblastoma-related Protein from Tomato Solanum lycopersicum L.

Health Services Insights
Predictors of Willingness to Participate in Health Insurance Services Among the Community of Jimma Town, Southwest Ethiopia

International Journal of Insect Science
Insecticides and Bio-insecticides Modulate the Glutathione-related Antioxidant Defense System of Cowpea Storage Bruchid (Callosobruchus maculatus)

Impact of the Argemone mexicana Stem Extracts on the Reproductive Fitness and Behavior of Adult Dengue Vector, Aedes aegypti L. (Diptera: Culicidae)

Japanese Clinical Medicine
Prospective Randomized Trial on Postoperative Administration of Diet Containing Eicosapentaenoic Acid, Docosahexaenoic Acid, Gamma-linolenic Acid, and Antioxidants in Head and Neck Cancer Surgery Patients with Free-flap Reconstruction

Journal of Cell Death
Optogenetic Control of Apoptosis in Targeted Tissues of Xenopus laevis Embryos

Journal of Central Nervous System Disease
Administration of an Amino Acid–Based Regimen for the Management of Autonomic Nervous System Dysfunction Related to Combat-Induced Illness

Idiopathic Ventral Spinal Cord Herniation: An Increasingly Recognized Cause of Thoracic Myelopathy

Journal of Genomes and Exomes
Many Breast Cancer Mutations Parallel Mutations in Known Viral Cancers

Journal of Medical Education and Curricular Development
Evaluation of the Assessment Plan for Undergraduate Clerkship in Obstetrics and Gynecology, King Abdulaziz University

Nutrition and Metabolic Insights
Randomized Controlled Trial to Compare Growth Parameters and Nutrient Adequacy in Children with Picky Eating Behaviors Who Received Nutritional Counseling With or Without an Oral Nutritional Supplement

Open Journal of Cardiovascular Surgery
Retraction: “Bedside Surgery to Treat Patent Ductus Arteriosus in Low-Birth-Weight Premature Infants”  http://www.la-press.com/retraction-bedside-surgery-to-treat-patent-ductus-arteriosus-in-low-bi-article-a4411

Perspectives in Medicinal Chemistry
Multiple Sclerosis: Overview of Disease-Modifying Agents 

Antimicrobial Peptides and Their Analogs: Searching for New Potential Therapeutics

Substance Abuse: Research and Treatment
Predictors of Staff Turnover and Turnover Intentions within Addiction Treatment Settings: Change Over Time Matters

Feasibility of Applying the Life History Calendar in a Population of Chronic Opioid Users to Identify Patterns of Drug Use and Addiction Treatment

Friday, October 24, 2014

Published This Week (20th October - 24th October)

We are pleased to announce the publication of the following peer reviewed papers.  Sign up to receive email alerts to receive immediate notification of new papers.


Cancer Informatics
Network-Based Identification of Biomarkers Coexpressed with Multiple Pathways

StickWRLD as an Interactive Visual Pre-Filter for Canceromics-Centric Expression Quantitative Trait Locus Dataz 

A Comprehensive Comparison of Normalization Methods for Loading Control and Variance Stabilization of Reverse-Phase Protein Array Data

Network Analysis of Cancer-focused Association Network Reveals Distinct Network Association Patterns

Co-expression Network Analysis of Human lncRNAs and Cancer Genes

The Axis of Progression of Disease

eMBI: Boosting Gene Expression-based Clustering for Cancer Subtypes

Classification of Images Acquired with Colposcopy Using Artificial Neural Networks

Learning Dysregulated Pathways in Cancers from Differential Variability Analysis

Clinical Medicine Insights: Cardiology
Impact of D-Dimers on the Differential Diagnosis of Acute Chest Pain: Current Aspects Besides the Widely Known

The Association of Pre-Existing Left Atrial Fibrosis with Clinical Variables in Patients Referred for Catheter Ablation of Atrial Fibrillation

Diagnosis and Management of Valvular Aortic Stenosis

Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine
Perceptions of Received Information, Social Support, and Coping in Patients with Pulmonary Arterial Hypertension or Chronic Thromboembolic Pulmonary Hypertension    

Evolutionary Bioinformatics
Comparative Study on Sequence–Structure–Function Relationship of the Human Short-chain Dehydrogenases/Reductases Protein Family

Cloning and Expression Profiling of the Polycomb Gene, Retinoblastoma-related Protein from Tomato Solanum lycopersicum L.

Health Services Insights
Predictors of Willingness to Participate in Health Insurance Services Among the Community of Jimma Town, Southwest Ethiopia

International Journal of Insect Science
Insecticides and Bio-insecticides Modulate the Glutathione-related Antioxidant Defense System of Cowpea Storage Bruchid (Callosobruchus maculatus)

Japanese Clinical Medicine
Prospective Randomized Trial on Postoperative Administration of Diet Containing Eicosapentaenoic Acid, Docosahexaenoic Acid, Gamma-linolenic Acid, and Antioxidants in Head and Neck Cancer Surgery Patients with Free-flap Reconstruction

Friday, October 17, 2014

Published This Week (13th October - 17th October)

We are pleased to announce the publication of the following peer reviewed papers. Sign up to receive email alerts to receive immediate notification of new papers.

Bone and Tissue Regeneration Insights
Characterization of Human Anulus Fibrosus- and Nucleus Pulposus-Derived Cells During Monolayer Expansion and in Hydrogel Cultures

Breast Cancer: Basic and Clinical Research
RAD51B Activity and Cell Cycle Regulation in Response to DNA Damage in Breast Cancer Cell Lines

Hereditary Breast Cancer: Clinical, Pathological and Molecular Characteristics

Cancer Informatics
Introductory Editorial: Computational Advances in Cancer Informatics (A)

Inferring Aberrant Signal Transduction Pathways in Ovarian Cancer from TCGA Data

Optimization of Network Topology in Computer-Aided Detection Schemes Using Phased Searching with NEAT in a Time-Scaled Framework

Mining Cancer-Specific Disease Comorbidities from a Large Observational Health Database

Text Mining in Cancer Gene and Pathway Prioritization

Modeling Signal Transduction from Protein Phosphorylation to Gene Expression

CSNK1A1 and Gli2 as Novel Targets Identified Through an Integrative Analysis of Gene Expression Data, Protein-Protein Interaction and Pathways Networks in Glioblastoma Tumors: Can These Two Be Antagonistic Proteins?

RNAseqPS: A Web Tool for Estimating Sample Size and Power for RNAseq Experiment

Inferring the Effects of Honokiol on the Notch Signaling Pathway in SW480 Colon Cancer Cells

Feasibility and Implementation of a Literature Information Management System for Human Papillomavirus in Head and Neck Cancers with Imaging

Exploiting Literature-derived Knowledge and Semantics to Identify Potential Prostate Cancer Drugs

Prediction of MicroRNA Precursors Using Parsimonious Feature Sets

Disease Biomarker Query from RNA-Seq Data

Integrated DNA Copy Number and Gene Expression Regulatory Network Analysis of Non-small Cell Lung Cancer Metastasis

Toolbox for Mobile-Element Insertion Detection on Cancer Genomes

Mapping Splicing Quantitative Trait Loci in RNA-Seq

TEGS-CN: A Statistical Method for Pathway Analysis of Genome-wide Copy Number Profile

Unsupervised Outlier Profile Analysis

CORM: An R Package Implementing the Clustering of Regression Models Method for Gene Clustering

Profiling the microRNA Expression in Human iPS and iPS-derived Retinal Pigment Epithelium

Master Regulators, Regulatory Networks, and Pathways of Glioblastoma Subtypes

Network-based Prediction of Cancer under Genetic Storm

Quality Control for RNA-Seq (QuaCRS): An Integrated Quality Control Pipeline

Automated Recommendation for Cervical Cancer Screening and Surveillance

Clinical Medicine Insights: Gastroenterology
Diabetic Ketoacidosis-induced Hypertriglyceridemic Acute Pancreatitis Treated with Plasmapheresis-Recipe for Biochemical Disaster Management

Clinical Medicine Insights: Reproductive Health
Individualized Treatment from Theory to Practice: The Private Case of Adding LH during GnRH Antagonist-based Stimulation Protocol

Environmental Health Insights
Identification of Larvicide-Resistant Catch Basins from Three Years of Larvicide Trials in a Suburb of Chicago, IL

Volitional Weight-Lifting in Rats Promotes Adaptation via Performance and Muscle Morphology prior to Gains in Muscle Mass

Evaluation of the Pulmonary Toxicity of a Fume Generated from a Nickel-, Copper-Based Electrode to be Used as a Substitute in Stainless Steel Welding

International Journal of Insect Science
Impact of the Argemone mexicana Stem Extracts on the Reproductive Fitness and Behavior of Adult Dengue Vector, Aedes aegypti L. (Diptera: Culicidae)

Journal of Cell Death
Optogenetic Control of Apoptosis in Targeted Tissues of Xenopus laevis Embryos

Journal of Genomes and Exomes
Many Breast Cancer Mutations Parallel Mutations in Known Viral Cancers

Perspectives in Medicinal Chemistry
Antimicrobial Peptides and Their Analogs: Searching for New Potential Therapeutics

 

Friday, October 10, 2014

Published Recently (6th October - 10th October)

We are pleased to announce the publication of the following peer reviewed papers. Sign up to receive email alerts to receive immediate notification of new papers.

Biomarker Insights
Decreased Mitogen Inducible Gene 6 (MIG-6) Associated with Symptom Severity in Children with Autism

Bone and Tissue Regeneration Insights
A Review of the Pathogenesis of Osteoarthritis and the Use of Intra-articular Platelet Therapy for Joint Disease in Animals and Humans

Breast Cancer: Basic and Clinical Research
Update on Adjuvant Chemotherapy for Early Breast Cancer

Cancer Informatics
Combined Benefit of Prediction and Treatment: A Criterion for Evaluating Clinical Prediction Models

Clinical Medicine Insights: Case Reports
Late-Onset Screw Migration into Iliac Vessels 21 years after Hip Arthrodesis

Journal of Central Nervous System Disease
Administration of an Amino Acid-Based Regimen for the Management of Autonomic Nervous System Dysfunction Related to Combat-Induced Illness

Perspectives in Medicinal Chemistry
Multiple Sclerosis: Overview of Disease-Modifying Agents

Five More Journals Added to Pubmed

We are pleased to announce that five more Libertas Academica journals are now available on Pubmed.

These are;

- Biomedical Engineering and Computational Biology
- Journal of Cell Death
- Lipid Insights
- Palliative Care: Research and Treatment
- Proteomics Insights

Having our journals included in Pubmed means enhanced visibility for published papers and permanent archiving of papers in Pubmed Central in addition to our existing archiving arrangements with CLOCKSS and LOCKSS. It also means all newly published papers will be added to Pubmed within approximately ten days following publication.

The full list of all our journals, including the 44 listed on Pubmed, can be found on our Journals Webpage.

Tuesday, September 30, 2014

Published During September

We are pleased to announce the publication of the following papers during month. Sign up to receive email alerts to receive immediate notification of new papers. 

Air, Soil and Water Research
Evaluation of the Horizontal Wave Forces on Piles

Autism Insights

Role of Environmental Exposure to Toxins and Microbial Infections in Autism 

Bioinformatics and Biology Insights
Integrated Analysis of Dysregulated miRNA-gene Expression in HMGA2-silenced Retinoblastoma Cells

Interactions Among Plant Transcription Factors Regulating Expression of Stress-responsive Genes

Biomarker Insights
Increased Expression of Phosphorylated FADD in Anaplastic Large Cell and Other T-Cell Lymphomas

Cancer Informatics

Introductory Editorial: Classification, Predictive Modelling, and Statistical Analysis of Cancer Data (A)

Functional Annotation of Putative Regulatory Elements at Cancer Susceptibility Loci

A Review of Cancer Risk Prediction Models with Genetic Variants

A Bayesian Integrative Model for Genetical Genomics with Spatially Informed Variable Selection

Integrative Bayesian Network Analysis of Genomic Data


Integrated Analysis of Whole-Genome Paired-End and Mate-Pair Sequencing Data for Identifying Genomic Structural Variations in Multiple Myeloma

Comparative Study of Computational Methods for Reconstructing Genetic Networks of Cancer-Related Pathways

Review of Current Methods, Applications, and Data Management for the Bioinformatics Analysis of Whole Exome Sequencing


Clinical Medicine Insights: Cardiology
Effects of Fibrosis Morphology on Reentrant Ventricular Tachycardia Inducibility and Simulation Fidelity in Patient-Derived Models 

Implementation of Ultraportable Echocardiography in an Adolescent Sudden Cardiac Arrest Screening Program

Clinical Medicine Insights: Case Reports
Mycosis Fungoides: Case Report and Literature Review 

Osteonecrosis of the Femoral Head with Collapsed Medial Lesion

Concealed Sinus Node Dysfunction and Paradoxical Effect of Atropine during Arrhythmia Diagnostic Pharmacological Testing

Syringomyelia Associated with Spinal Arachnoiditis Treated by Partial Arachnoid Dissection and Syrinx-Far Distal Subarachnoid Shunt


Three Cases of Immature Teratoma Diagnosed after Laparoscopic Operation

Giant Cardiac Hydatid Cyst in Children: Case Report and Review of the Literature


Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine

Adherence to Therapeutic Guidelines for Patients with Community-Acquired Pneumonia in Australian Hospitals

Improved Arterial Blood Oxygenation Following Intravenous Infusion of Cold Supersaturated Dissolved Oxygen Solution

Clinical Medicine Insights: Ear, Nose and Throat
Impact of Treatment Time on the Survival of Patients Suffering From Invasive Fungal Rhinosinusitis

Clinical Medicine Insights: Endocrinology and Diabetes
A Clinical Perspective of Canagliflozin in the Management of Type 2 Diabetes Mellitus

Clinical Medicine Insights: Oncology
Tandem Autologous Stem Cell Transplantation for Multiple Myeloma Patients Based on Response to Their First Transplant—A Prospective Phase II Study

Human Papilloma Virus and Squamous Cell Carcinoma of the Anus

Difference between Luminal A and Luminal B Subtypes According to Ki-67, Tumor Size, and Progesterone Receptor Negativity Providing Prognostic Information

Clinical Medicine Insights: Pediatrics
Factors Associated with Delayed Cancer Diagnosis in Egyptian Children

Distal Deletion of Chromosome 11q Encompassing Jacobsen Syndrome without Platelet Abnormality


Chronic Lymphocytic Leukemia with t(14;18)(q32;q21) As a Sole Cytogenetic Abnormality

Evolutionary Bioinformatics
The Comparative Genomics and Phylogenomics of Leishmania amazonensis Parasite

Genetics & Epigenetics

Maternal Stress, Preterm Birth, and DNA Methylation at Imprint Regulatory Sequences in Humans

Genomic Insights
Reassessment of the Genome Size in Elaeis guineensis and Elaeis oleifera, and Its Interspecific Hybrid

International Journal of Tryptophan Research
Imbalanced Kynurenine Pathway in Schizophrenia

Japanese Clinical Medicine
Liraglutide Versus Sitagliptin in a 24-week, Multicenter, Open-label, Randomized, Parallel-group Study in Japanese Type 2 Diabetes Mellitus Patients Responding Inadequately to a Sulfonylurea and/or One or Two Other Oral Antidiabetic Drugs (JDDM 33)

Functioning Endometrium and Endometrioma in a Patient with Mayer-Rokitanski-Kuster-Hauser Syndrome

Journal of Central Nervous System Disease
Increased Epidermal Growth Factor Receptor (EGFR) Associated with Hepatocyte Growth Factor (HGF) and Symptom Severity in Children with Autism Spectrum Disorders (ASDs)

Lymphoma and Chronic Lymphocytic Leukemias
A New Era is Coming up in the Treatment of Chronic Lymphocytic Leukemia

Microbiology Insights
Limitations of Using Propidium Monoazide with qPCR to Discriminate between Live and Dead Legionella in Biofilm Samples
    
Retrovirology: Research and Treatment
HIV Self-testing in Sub-Saharan Africa: Strategies to Enhance and Measure Linkage to Care

Perspective on Providing Partner Notification Services for HIV in Sub-Saharan Africa

Substance Abuse: Research and Treatment
Sleep Disturbances in Individuals with Alcohol-Related Disorders: A Review of Cognitive-Behavioral Therapy for Insomnia (CBT-I) and Associated Non-Pharmacological Therapies

Monday, September 29, 2014

New Supplements Program

This week we published a new Cancer Informatics supplement “Classification, Predictive Modelling, and Statistical Analysis of Cancer Data (A)”, the first in our new supplements program.

Supplements contain a set of peer reviewed papers written by notable researchers who work in leading international institutions, and are published with an editorial written by the supplement’s guest editors.

Learn more about the program here:  http://www.la-press.com/about_us.php?folder_id=235