Tuesday, August 19, 2014

Three More Journals Added to Pubmed

We are pleased to announce that three more Libertas Academica journals are now available on Pubmed.

These are;

-    Biochemistry Insights

-    Health Services Insights

-    Magnetic Resonance Insights


Having our journals included in Pubmed means enhanced visibility for published papers and permanent archiving of papers in Pubmed Central in addition to our existing archiving arrangements with CLOCKSS and LOCKSS. It also means all newly published papers will be added to Pubmed within approximately ten days following publication.

The full list of all our journals, including the 38 listed on Pubmed, can be found on the Journals Webpage.

Friday, August 15, 2014

Published Recently (9th August – 15th August)

We are pleased to announce the publication of the following peer reviewed papers.  Sign up to receive email alerts to receive immediate notification of new papers.


Bioinformatics and Biology Insights

Computational Identification of Dengue Virus MicroRNA-Like Structures and their Cellular Targets

Biomarker Insights

Identification of Gene Signatures Used to Recognize Biological Characteristics of Gastric Cancer Upon Gene Expression Data

Cancer Growth and Metastasis

Bone Disease in Multiple Myeloma: Pathophysiology and Management

Cell & Tissue Transplantation & Therapy

Use of Adult Stem Cells for Orthopedic Regenerative Medicine Applications

Clinical Medicine Insights: Blood Disorders

Ribosomopathies: Mechanisms of Disease

Clinical Medicine Insights: Cardiology

Aborted Sudden Cardiac Death and a Mother with Suspected Metabolic Myopathy

Clinical Medicine Insights: Case Reports

Cutaneous Necrosis As a Result of Isosulphane Blue Injection in Mammarian Sentinel Lymph Node Mapping: Report of Two Cases

Effect of Vitamin D3 on Untreated Graves’ Disease with Vitamin D Deficiency

Clinical Medicine Insights: Ear, Nose and Throat

Myringoplasty with and without Cortical Mastoidectomy in Treatment of Non-cholesteatomatous Chronic Otitis Media: A Comparative Study

Clinical Medicine Insights: Reproductive Health

The Low Prevalence of Y Chromosomal Microdeletions is Observed in the Oligozoospermic Men in the Area of Mato Grosso State and Amazonian Region of Brazilian Patients

Drug Target Insights

Febuxostat for Hyperuricemia in Patients with Advanced Chronic Kidney Disease

Immunology and Immunogenetics Insights

HLA-A, -B, -C, -DRB1, and -DQB1 Allele Lineages and Haplotype Frequencies among Saudis

Japanese Clinical Medicine

Dynamic Change in Cells Expressing IL-1β in Rat Hippocampus after Status Epilepticus

Neurological Toxicity in Metastatic Colorectal Cancer Patients Treated with Modified FOLFOX6 Plus Bevacizumab

Lymphoma and Chronic Lymphocytic Leukemias
New Therapies in T-cell Lymphoma

Friday, August 1, 2014

Published This Week (28th July - 1st August)

We are pleased to announce the publication of the following peer reviewed papers.  Sign up to receive email alerts to receive immediate notification of new papers.

Biomarker Insights
Hydroxyproline, a Serum Biomarker Candidate for Gastric Ulcer in Rats: A Comparison Study of Metabolic Analysis of Gastric Ulcer Models Induced by Ethanol, Stress, and Aspirin

Breast Cancer: Basic and Clinical Research

Breast Cancer Characteristics and Survival in a Hispanic Population of Costa Rica
Current Approaches and Emerging Directions in HER2-resistant Breast Cancer
Breast Positioning during Mammography: Mistakes to be Avoided

Cancer Informatics
Integrative Pathway Analysis Using Graph-Based Learning with Applications to TCGA Colon and Ovarian Data

Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders

Incidence and Risk of Infection in Egyptian Patients with Systemic Lupus Erythematosus

Clinical Medicine Insights: Case Reports

Do We Have to Perform a Renal Biopsy? Clinical Dilemmas in a Case with Nephrotic Syndrome
Schwannoma of the Median Nerve: Diagnosis Sometimes Delayed

Clinical Medicine Insights: Endocrinology and Diabetes

Age and Menopausal Status Affect Osteoprotegerin and Osteocalcin Levels in Women Differently, Irrespective of Thyroid Function

Clinical Medicine Insights: Reproductive Health

Combined First-Trimester Screening in Northern Finland: Experiences of the First Ten Years

Drug Target Insights

Molecular and Kinetic Characterization of Babesia microti Gray Strain Lactate Dehydrogenase as a Potential Drug Target

Evolutionary Bioinformatics

An In-depth Analysis of a Multilocus Phylogeny Identifies leuS As a Reliable Phylogenetic Marker for the Genus Pantoea

Healthy Aging & Clinical Care in the Elderly

Lifestyle Changes in the Prevention of Mobility Disability

Retrovirology: Research and Treatment
Perspective on HIV Self-testing in North America: A Tale of Two Countries—US and Canada

Thursday, July 31, 2014

Published During July

We are pleased to announce the publication of the following papers during the month.  Sign up to receive email alerts to receive immediate notification of new papers.

Advances in Tumor Virology

Tumor Cell Development: A Role for Viruses and Telomerase Activity?

Analytical Chemistry Insights

Preliminary Development of a Fiber Optic Sensor for Measuring Bilirubin

Biomarkers in Cancer

Biomarkers of HIV-associated Cancer

Biomarker Insights

DNA Methylation at the Novel CpG Sites in the Promoter of MED15/PCQAP Gene as a Biomarker for Head and Neck Cancers

Hydroxyproline, a Serum Biomarker Candidate for Gastric Ulcer in Rats: A Comparison Study of Metabolic Analysis of Gastric Ulcer Models Induced by Ethanol, Stress, and Aspirin

Breast Cancer: Basic and Clinical Research

Breast Cancer Characteristics and Survival in a Hispanic Population of Costa Rica

Current Approaches and Emerging Directions in HER2-resistant Breast Cancer

Breast Positioning during Mammography: Mistakes to be Avoided

Cancer Informatics

On the Significance of Fuzzification of the N and M in Cancer Staging

Integrative Pathway Analysis Using Graph-Based Learning with Applications to TCGA Colon and Ovarian Data

Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders

Incidence and Risk of Infection in Egyptian Patients with Systemic Lupus Erythematosus

Clinical Medicine Insights: Cardiology

Electromagnetic Interference with Implantable Cardioverter Defibrillators Causing Inadvertent Shock: Case Report and Review of Current Literature

Q192R Paraoxonase (PON)1 Polymorphism, Insulin Sensitivity, and Endothelial Function in Essential Hypertensive Men

Clinical Medicine Insights: Case Reports

Bilateral Carotid Paraganglioma: Surgery and Radiotherapy

Personalization of Chemotherapy for Metastatic Pancreatic Cancer

Reversible Ototoxicity: A Rare Adverse Reaction of Liposomal Amphotericin-B Used for the Treatment of Antimony-Resistant Visceral Leishmaniasis in an Elderly Male

Do We Have to Perform a Renal Biopsy? Clinical Dilemmas in a Case with Nephrotic Syndrome

Schwannoma of the Median Nerve: Diagnosis Sometimes Delayed

Clinical Medicine Insights: Dermatology

A Rare Finding of Onychoheterotopia (Ectopic Nail) in a Case of Systemic Sclerosis

Ingenol Mebutate

Clinical Medicine Insights: Ear, Nose and Throat

Laser Posterior Cordotomy: Is it a Good Choice in Treating Bilateral Vocal Fold Abductor Paralysis?

Clinical Medicine Insights: Endocrinology and Diabetes

Age and Menopausal Status Affect Osteoprotegerin and Osteocalcin Levels in Women Differently, Irrespective of Thyroid Function

Clinical Medicine Insights: Gastroenterology

Primary and Secondary Prevention of Colorectal Cancer

Clinical Medicine Insights: Oncology

Advanced Extramammary Paget's Disease of the Groin, Penis, and Scrotum

Case Report About Fatal or Near-Fatal Hypersensitivity Reactions to Cetuximab: Anticetuximab IgE as a Valuable Screening Test

Clinical Medicine Insights: Reproductive Health

Combined First-Trimester Screening in Northern Finland: Experiences of the First Ten Years

Clinical Medicine Insights: Trauma and Intensive Medicine

Role of Damage Control Orthopedics and Early Total Care in the Multiple Injured Trauma Patients

Clinical Medicine Insights: Women's Health

Women Living with HIV in Rural Areas. Implementing a Response using the HIV and AIDS Risk Assessment and Reduction Model

Drug Target Insights

Molecular and Kinetic Characterization of Babesia microti Gray Strain Lactate Dehydrogenase as a Potential Drug Target

Evolutionary Bioinformatics

Regulation of Human PAX6 Expression by miR-7

An In-depth Analysis of a Multilocus Phylogeny Identifies leuS As a Reliable Phylogenetic Marker for the Genus Pantoea

Genetics & Epigenetics

Copy Number Variation of TLR-7 Gene and its Association with the Development of Systemic Lupus Erythematosus in Female Patients from Yucatan Mexico

Healthy Aging & Clinical Care in the Elderly

Lifestyle Changes in the Prevention of Mobility Disability

Journal of Central Nervous System Disease

Vanishing White Matter Disease in a Spanish Population

Nutrition and Metabolic Insights

Role of Bioactive Food Components in Diabetes Prevention: Effects on Beta-Cell Function and Preservation

Retrovirology: Research and Treatment

Perspective on HIV Self-testing in North America: A Tale of Two Countries—US and Canada

 

Wednesday, July 30, 2014

Interview with Author Dr Huriye Kızıltan

This author interview is by Dr Huriye Şenay Kızıltan, of Bezmialem Vakif University Faculty of Medicine, Turkey.  Dr Kiziltan's full paper, Bilateral Carotid Paraganglioma: Surgery and Radiotherapy, is available for download in Clinical Medicine Insights: Case Reports.

Please summarise for readers the content of your article.

Paragangliomas are relatively rare vascular tumors that develop from the neural crest cells of carotid bifurcation. They are usually presented as slow growing painless unilateral neck mass; bilateral presentation is rare and mostly associated with familial form. Bilateral total resection is not always possible for high grade bilateral tumors and radiotherapy is a good alternative with cure rates similar to surgery.

How did you come to be involved in your area of study?

Because radiotherapy is generally believed to be ineffective in paraganglioma and bilateral paraganglioma cases usually can not be an effective treatment.

What was previously known about the topic of your article?

There was some information in the literature but now I've sought to analyze this information.

How has your work in this area advanced understanding of the topic?

I collected and analysed informational literature. For example: Octreotide scanning is useful test also for showing multicentric or metastatic paragangliomas. It may also distinguish scar from residual tumor after surgery. Recent literature showed that some paragangliomas have been as a result of germline mutations. Molecular studies revealed that six genes have been identified for germ line mutations of paraganglioma. These include RET, VHL,NF1 and SDH.  Succinate dehydrogenase (SDH) subunits are SDHB, SDHC, and SDHD. SDHD and SDHB mutations are very important for head and neck paragangliomas. Initially, paragangliomas may not response to radiotherapy, but eventually these tumors get smaller in a time period of two years. Long-term cure rates are similar for surgery and radiotherapy. Kyrch et al. reported the tumor control results of radiotherapy (EBRT and SRS methods) in a follow-up period of 10 years; tumor control was 92%.

What do you regard as being the most important aspect of the results reported in the article?
Initially, paragangliomas may not respond to radiotherapy, but eventually these tumors get smaller over a time period of two years. Long-term cure rates are similar for surgery and radiotherapy. The tumor control was up to 90% for radiotherapy (EBRT and SRS methods) in a follow-up period of ten years.

http://www.bezmialem.edu.tr/en/academic-units/faculties/faculty-of-medicine

Tuesday, July 29, 2014

Interview with Author Dr Ravi Sahu

This author interview is by Dr Ravi P. Sahu, of Indiana University School of Medicine.  Dr Sahu's full paper, Systemic Platelet-activating factor receptor activation augments experimental lung tumor growth and metastasis, is available for download in Cancer Growth and Metastasis.

First please summarise for readers the content of your article 

Pro-oxidative stressors that generate free radicals including ultraviolet B (UVB) and cigarette smoke (CS) are associated with the suppression of the host immune system resulting in various pathological diseases including lung cancer growth and metastasis. Thus, an investigation of potent immune mediator(s) involved in mediating UVB/CS-induced immunosuppression could lead to an identification of novel strategies to block these deleterious effects. Our previous studies have shown that novel lipids with platelet-activated factor-receptor (PAF-R) agonistic activity mediate UVB/CS induced systemic immunosuppression. In addition, these UVB-generated oxidized-PAF-R-agonists augment experimental murine B16F10 melanoma tumor growth in a PAF-R-dependent manner mediated via upregulation of suppressive immune cell types, regulatory T cells (Tregs). As CS generates PAF-R agonists, our recently published studies sought to determine the impact of PAF-R agonists on lung cancer growth and metastasis. Using the murine Lewis Lung Carcinoma (LLC1) model, we have demonstrated that treatment of syngeneic C57BL/6 mice with a PAF-R agonist augments lung tumor growth and its metastasis to the lung in a PAF-R-dependent manner as these findings were not seen in PAF-R-deficient mice. Importantly, this effect was observed to be dependent on host rather than tumor cells PAF-R as LLC1 cells do not express functional PAF-R. These findings indicate that experimental lung cancer progression can be modulated by the PAF system.

How did you come to be involved in your area of study?

Our previous studies have provided compelling evidences that oxidized PAF-R agonists produced via pro-oxidative stressors such as UVB induce systemic immunosuppression in a PAF-R dependent manner. However, the functional significance of this PAF-R agonists mediated systemic immunosuppressive effects was not known. We have recently shown that chronic persistence of host immunosuppression results in enhanced growth of murine B16F10 melanoma tumors. However, whether this PAF-R agonists mediated effects are limited to melanoma or is a generalized event and could also affect the growth of other tumor types was unknown. In our recently published article, we sought to determine if PAF-R agonists induced systemic immunosuppression could modulate the growth of lung cancer and its metastasis using murine LLC1 lung cancer cells as a model. This published study has significant relevance as we have shown that exposure to cigarette smoke generates oxidized PAF-R agonists that mediates its systemic immunosuppressive effects.

What was previously known about the topic of your article?

Our previous studies have established that oxidized lipid mediators with PAF-R agonistic activity mediate the immunosuppressive effects of pro-oxidative stressor such as UVB that results in an augmentation of experimental murine B16F10 melanoma tumor growth in a PAF-R dependent manner.

How has your work in this area advanced understanding of the topic?

Exposure to cigarette smoke (active and passive) has been shown to exert immunosuppressive effects that result in various health-related issues including initiation and progression of lung cancer. However, the molecular mechanism involved in mediating this CS-induced systemic immunosuppression is not known. Our studies have provided a potential mechanism that PAF-agonists play critical role as effectors in CS-mediated immunosuppression that in a long run results in the progression of pre-existing lung tumors.

What do you regard as being the most important aspect of the results reported in the article?

These findings indicate that experimental lung cancer progression can be modulated by the PAF-R signaling.

Saturday, July 26, 2014

35 Libertas Journals now in Pubmed

Libertas is progressively adding more journals to Pubmed, with 35 now available on Pubmed and a large quantity in the latter stages of evaluation by the National Library of Medicine.

What does inclusion of a journal in Pubmed mean?

  • Enhanced visibility for published papers

  • All new papers published in the journal are added to Pubmed

  • Permanent archiving of papers in Pubmed Central in addition to our existing archiving arrangements with CLOCKSS and LOCKSS

New journals are added to Pubmed regularly.  To learn which journals are indexed by Pubmed visit the Journals webpage

 

Wednesday, July 23, 2014

Interview with Author Dr Hong Xue

This author interview is by Dr Hong Xue, of Hong Kong University of Science and Technology.  Dr Xue's full paper, Application of machine learning to development of copy number variation-based prediction of cancer risk, is available for download in Genomics Insights.

First please summarise for readers the content of your article.

Using machine learning, we have developed a procedure for predicting hereditary cancer risk based on the recurrent (or common) copy number variations occurring in individuals’ constitutional (or germ-line) genomes.

How did you come to be involved in your area of study?

Our research laboratory is a participating laboratory in the International Cancer Genome Consortium, for which I am coordinating the Hong Kong team of researchers from Hong Kong University of Science and Technology, Hong Kong University and the Chinese University of Hong Kong.

What was previously known about the topic of your article?

Some rare somatic forms of copy number variations (CNVs) are observed in cancer tissues. However, hitherto commonly occurring CNVs in individuals’ constitutional genomes, as measure with non-cancerous peripheral leukocytes, are not known to be associated with cancer risk.

How has your work in this area advanced understanding of the topic?

By showing that cancer risk can be assessed based on recurrent CNVs, our work has opened up the use of such CNVs for cancer prediction, and hence predictive medicine for cancers.

What do you regard as being the most important aspect of the results reported in the article?

There are two most important aspects of our work. First, it has increased the usefulness of cancer prediction, thereby enhancing the potential utility of cancer prediction. Secondly, it has identified a number of recurrent CNVs with an ethnic population that are associated with high cancer risk or low cancer risk. Each of the CNV features will open up a line of enquiry to deepen our insight into the underlying factors of cancer development.

You can learn more about Dr Xue and her work here;
http://life-sci.ust.hk/faculty/Prof.H.Xue/index.html

Friday, July 18, 2014

Published Recently (7th July– 18th July)

We are pleased to announce the publication of the following peer reviewed papers. 

Sign up to receive email alerts to receive immediate notification of new papers.

Clinical Medicine Insights: Cardiology
Q192R Paraoxonase (PON)1 Polymorphism, Insulin Sensitivity, and Endothelial Function in Essential Hypertensive Men

Clinical Medicine Insights: Dermatology
Ingenol Mebutate

Clinical Medicine Insights: Gastroenterology
Primary and Secondary Prevention of Colorectal Cancer

Clinical Medicine Insights: Oncology
Advanced Extramammary Paget's Disease of the Groin, Penis, and Scrotum

Evolutionary Bioinformatics
Regulation of Human PAX6 Expression by miR-7

Journal of Central Nervous System Disease
Vanishing White Matter Disease in a Spanish Population

Nutrition and Metabolic Insights
Role of Bioactive Food Components in Diabetes Prevention: Effects on Beta-Cell Function and Preservation

Professional Integrity in Scholarly Publishing

Libertas recognizes the importance of our role in the scholarly communication process.  This is manifested by how we address important ethical matters relating to matters such as authorship.  

When he raised a concern with us Dr Selim Mustafa (East Carolina University) was satisfied with how the matter was addressed:

“I am highly impressed with the professional integrity, efficiency, and friendly communication of the editorial staff at Libertas Academia.  Recently, I had an authorship issue which I brought to the attention of the Publisher and CEO (Mr. Tom Hill) of the journal Air, Soil, and Water Research.  The issue was taken very seriously and was handled appropriately in an efficient and timely manner.  I would like to express my sincere appreciation and utmost  respect  for the Publisher and the staff at Libertas Academica for their attention, efforts, and dedication to maintaining the high quality and integrity of their publications.”

 

Wednesday, July 16, 2014

New Editor in Chief – Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders

We welcome Dr Chuanju Liu as the new Editor in Chief of Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders.

Dr Chuanju Liu is a Professor in the Departments of Orthopedic Surgery and Cell Biology at New York University School of Medicine (NY.)  Dr Liu obtained his PhD in molecular, cellular and developmental biology from Shandong University and obtained post-doctoral training at Yale University.  

Dr Liu has received numerous awards, including the Harold M. Frost Award from the American Society for Bone and Mineral Research, the Dorothy W. Goldstein Award from the Arthritis Foundation, the Career Development Award from National Institute of Health, the Ethelmae Haldan Award for Innovative Science from the Arthritis National Research Foundation, the Kappa Delta Award from the American Academy of Orthopaedic Surgeons, and the Basic Research Award from the American College of Rheumatology.

View the Clinical Medical Insights: Arthritis and Musculoskeletal Disorders journal here

New Editor in Chief - Clinical Medicine Insights: Women's Health

We are happy to announce the addition of Dr Marlene von Friederichs-Fitzwater to the position of Editor in Chief of Clinical Medicine Insights: Women's Health.

Dr Marlene von Friederichs-Fitzwater holds multiple appointments at the University of California, Davis, where she is an Associate Adjunct Professor in the School of Medicine, a Behavioural/Health Disparities Scientist, and Director of the Outreach Research and Education Program at the UC Davis Comprehensive Cancer Centre.  She obtained her PhD at the University of Utah and holds professional memberships in  American Association of Public Health, Association for the Behavioral Sciences and Medical Education, Association for Women in Science, Fellow American Academy on Physician and Patient, Society for Public Health Education, Society of Behavioral Medicine, and the Society of Teachers for Family Medicine.  In 2003 she was honored by the International Biographical Centre (Cambridge, England) with the 21st Century Award for Achievement in Health Communication.  

View Dr von Friederichs-Fitzwater’s profile here