Author interview with Dr Koichiro Shiokawa

Dr Shiokawa is the author of Gene expression in pre-MBT embryos and activation of maternally-inherited program of apoptosis to be executed at around MBT as a fail-safe mechanism in Xenopus early embryogenesis which was recently published in Gene Regulation and Systems Biology.

The Editor in Chief of Gene Regulation and Systems Biology recently issued a call for papers.

Dr Shiokawa is a member of our favorite author program. Under the program authors are eligible to receive: prioritised peer review, prioritised author PDF, and an article processing fee discount. All former authors are eligible to join the favorite author program.

What is the primary focus of your research?

Control of Gene expression in Xenopus embryogenesis.

What are the most exciting developments arising from current research in your area?

jpGene expression in pre-MBT embryos and activation of maternally-inherited program of apoptosis to be executed at around MBT as a fail-safe mechanism in Xenopus early embryogenesisxpression

Who are your main collaborators? Please describe your work with them

Professor Kazuei Igarashi, who supported me in the above study as a specialist for polyamine research.

How did you come to be working in your research area?

My thesis was on this subject, Gene Expression in Xenopus early embryogenesis.

What do you think about the development of open access publishing? What motivated you to use it?

This is very good, because it is open to a wide variety of related researchers.

Other information

• Contact Dr Shiokawa
  

See call for papers for Gene Regulation and Systems Biology

Author interview with Dr Viggo Jønsson

Dr Jonsson is the author of Possible Imprinting and Microchimerism in Chronic Lymphocytic Leukemia and Related Lymphoproliferative Disorders which was recently published in Translational Oncogenomics.

The Editor in Chief of Translational Oncogenomics recently issued a call for papers.

Dr Jonsson is a member of our favorite author program. Under the program authors are eligible to receive: prioritised peer review, prioritised author PDF, and an article processing fee discount. All former authors are eligible to join the favorite author program.

Please describe your experience with Libertas Academica

I found the publishing process very good, easy and fast, and I was updated all the time. The referee report was competent, inspirating and helpful. The quality of layout, print and presentation in general was very nice, clear and easy for the reader to overlook. I was very satisfied.

What is the primary focus of your research?

Chronic lymphocytic leukemia (CLL) and malignant lymphomas (ML), their pathophysiology and genetics. Diagnostic procedures and treatment modalities.

What are the most exciting developments arising from current research in your area?

• The recent demonstration of familial susceptibility genes of CLL and ML, the genetic and epigenetic accumulation of mutated genes related to CLL allelic loci.

• The increasing knowledge on synergistic combinations of chemotherapy and CD-specific immunotherapy.
  

Who are your main collaborators? Please describe your work with them

Richard Houlston and Daniel Catovsky and their team in London, UK, with whom I have a close collaboration on genomewide screening. Martin Yuille in Manchester, UK, and Jørgen H. Olsen at the Cancer Registry in Copenhagen, Denmark, with whom my team is closely associated in epidemiological work on CLL, supported by Jørgen Hilden, Department of Biostatistics, University of Copenhagen, Denmark.

Gunnar Juliusson and Karin Karlsson, Department of Hematology, University of Lund, Sweden, are close friends and colleagues to our present team here in Oslo (Geir Tjønnfjord,Hematology Department, University of Oslo, Bernt Ly and Tom Johannesen, Norwegian Cancer Registry, Oslo.)

How did you come to be working in your research area?

I became interested in hematology as a medical student in Professor Aage Videbæk's laboratory in Copenhagen, later as his research fellow. In my Copenhagen time, I was invited to join the London group due to my access to the Danish Cancer Registry and its invaluabe amount of data for cancer epidemiology. And that work continued after I got my chair in Oslo, now also in collaboration with the Norwegian Cancer Registry.

What do you think about the development of open access publishing? What motivated you to use it?

Brisk and rapid circulation of new data and deductive considerations, faster response from fellow scientists perhaps. I like it but I do not have so much experience yet.
What articles and/or books have you published recently?

• Schaadt BK, Hendel HW, Gimsing P, Jønsson V, Pedersen H, Waldemar G, Hesse B. 99mAprotinin scintigraphy in amyloidosis. J Nuclear Med 2003; 44: 177-83
  

• Hilden J, Jønsson V, Wiik A. Pregnancy as exposure: A Mendelian model of the „impregnator load” as a trigger of foetus - vs.- mother processes, autoimmunity and leukaemia. Contr Clin Trials 2003; 24, suppl 3, 93
  

• Egelund Christensen B, Jønsson V. Blodsygdomme. In Schroeder TV, Schulze S, Hilsted J, Aldershvile J (eds) Basisbog i Medicin og Kirurgi. 3. udgave. København, Munksgaard Publ. 2004, pp. 727-767
  

• Gniadecki R, Rossen K, Ralfkier E, Thomsen K, Lange Skovgaard G, Jønsson V. CD56+ lymphoma with skin involvment,: Clinicopathological features and classification. Arch Dermatol 2004; 104: 427-36
  

• Jønsson V, Egelund Christensen M. Maligne hæmatologiske sygdomme. Rørth M, Storm HH (eds). Kræftsygdomme, Onkologi, København, FADL´s Forlag, 2004, pp 392- 411
  

• Karlsson K, Strömberg M, Jønsson V, Gill D, Hammerstrøm J, Wallvik J, Mulligan S, Bradstock K, Liliemark J, Juliusson G. Cladribin (CdA) or fludarabin (F) or high-dose intermittent chlorambucil (Chl) as first-line treatment of symptomatic chronic lymphocytic leukemia ? First interim analysis of data from the International Randomized Phase III Trial. Poster Session 740 III. Blood 2004; 104: 3470
  

• Egelund Christensen B, Jønsson V. Blodsygdomme. In Schroeder TV, Schulze S, Hilsted J, Aldershvile J (eds) Basisbog i Medicin og Kirurgi. 3. udgave. København, Munksgaard Publ. 2004, pp. 727-767
  

• Gniadecki R, Rossen K, Ralfkier E, Thomsen K, Lange Skovgaard G, Jønsson V. CD56+ lymphoma with skin involvment,: Clinicopathological features and classification. Arch Dermatol 2004; 104: 427-36
  

• Jønsson V, Egelund Christensen M. Maligne hæmatologiske sygdomme. Rørth M, Storm HH (eds). Kræftsygdomme, Onkologi, København, FADL´s Forlag, 2004, pp 392-411
  

• Karlsson K, Strömberg M, Jønsson V, Gill D, Hammerstrøm J, Wallvik J, Mulligan S, Bradstock K, Liliemark J, Juliusson G. Cladribin (CdA) or fludarabin (F) or high-dose intermittent chlorambucil (Chl) as first-line treatment of symptomatic chronic lymphocytic leukemia ? First interim analysis of data from the International Randomized Phase III Trial. Poster Session 740 III. Blood 2004; 104: 3470
  

• Jønsson V, Houlston R, Catovsky, Yuille M, Olsen JH, Fajber M, Brandt B, Sellick G, Allinson R, Wiik A. CLL family ”pedigree 14” revisited: 1947 – 2004. Leukemia 2005; 19: 1025-28
  

• Tjønnfjord G, Jønsson V, Ly B, Hammerstrøm J, Ernst P. Handlingsprogram for kronisk lymfatisk leukemi 2005. Norsk selskab for hematologi, national rekommendasjon
  

• Karlsson K, Stromberg M, Willander K, Jonsson V, Hammerstrom J, Uggla B, Wallvik J, Sundstrom G, Geisler C, Tobin G, Rosenquist R, Liliemark J, Juliusson G. IgH mutation status is of limited prognostic value in untreated symptomatic CLL patients, results from the prospective Internation Phase III Study. Leukemia & Lymphoma 2005; 46, S38
  

• Sellick GS, Webb EL, Allinson R, Matutes E, Dyer MJS, Jønsson V, Langerak AW, Mauro FR, Fuller S, Wiley J, Lyttelton M, Callea V, Yuille M, Catovsky D, Houlston R. A high-density SNP genomewide linkage scan for chronic lymphocytic leukemia-susceptibility loci. Am J Hum Genet 2005; 77: 420-29
  

• Lotfi K, Karlsson K, Fyrberg A, Juliusson G, Jønsson V, Petersen C, Eriksson S, Albertioni F. The pattern of deoxycytidine- and deoxyguanosine kinase activity in relation to messenger RNA expression in blood cells from untreated patients with B-cell chronic lymphocytic leukemia. Biochem Pharmacol 2006; 71: 882-90
  

• Jønsson V, Bock JE, Hilden J, Houlston RS, Wiik A. The influence of pregnancy on the development of autoimmunity in chronic lymphocytic leukemia. Leukemia & Lymphoma 2006; 47: 1481-87
  

• Jønsson V, Johannesen TB. Anticipation in lymphoproliferative disorders (editorial). Leukemia & Lymphoma 2006; 47: 2015-16
  

• Jønsson V. Arv og kræft (editorial). Ugeskr f Læg (Copenhagen) 2006; 168: 2327
  

• Jønsson V, Olsen JH. Arv og lymfoproliferativ sygdom. Ugeskr f Læg (Copenhagen) 2006: 168: 2361-66
  

• Bergmann O, Bruun B, Egelund Christensen B, Frimodt-Møller N, Jønsson V, Peterslund NA, Skinhøj P, Tvede M. Infektioner hos hæmatologiske og onkologiske patienter. Odense, Odense Universitetsforlag, 2006, ISBN 87-7674-075-7, pp 1-126
  

• Jønsson V, Christensen BE. Jern, B-vitaminer og medikamentell knoglemarvspåvirkning. In Kampmann JP, Brøsen K, Simonsen U (eds) Basal og Klinisk Farmakologi, 3. udgave, København, FADL´s Forlag, 2007, Kapitel 58, pp 655-64
  

• Jønsson V, Hasselbalch, Christensen BE. Blodsygdomme. In Schroeder TV, Schulze S, Hilsted J, Gøtzsche L (eds) Basisbog i Medicin og Kirurgi, 4. udgave. København, Munksgaard Publ., Gyldendal, 2007, Kapitel 21, pp 693-736
  

• Jønsson V, Tjønnfjord GE, Samuelsen SO, Johannesen TB, Ly B. Pleiotrophy in familial CLL. Leukemia & Lymphoma 2007; 48: S124
  

• Karlsson K, Strömberg M, Jønsson V, Mulligan S, Liliemark J, Juliusson G. Improved response duration from first-line treatment with cladribine (CdA) as compared to fludarabine (F) or high-dose intermittent chlorambucil (Chl) for first-line treatment of symptomatic chronic lymphocytic leukemia (CLL). First results from the International Randomized Phase III Trial. Leukemia & Lymphoma 2007; 48: S167-68
  

• Jønsson V, Johannesen TB, Samuelsen SO, Ly B, Bock J, Tjønnfjord GE. On the genetics of chronic lymphocytic leukemia. Annotation. Elsevier Inform, Buenos Aires, submitted on Editor´s request 2007, www.siicsalud.com. November 6th,2007
  

• Jønsson V, Tjønnfjord G, Samuelsen SO, Johannesen T, Olsen J, Sellick G, Houlston R, Yuille M, Catovsky D. Birth order pattern in the inheritance of chronic lymphocytic leukaemia and related lymphoproliferative diseases. Leukemia & Lymphoma 2007; 48: 2387-96
  

• Karlsson K, Strömberg M, Jønsson V, Mulligan S, Liliemark J, Juliusson G. Improved response duration from first-line treatment with cladribine (CdA) as compared to fludarabine (F) or high-dose intermittent chlorambucil (Chl) for first-line treatment of symptomatic chronic lymphocytic leukemia (CLL). First results from the International Randomized Phase III Trial. Leukemia & Lymphoma 2007; 48: S167-68
  

• Jønsson V, Tjønnfjord G, Samuelsen SO, Johannesen T, Olsen J, Sellick G, Houlston R, Yuille M, Catovsky D. Birth order pattern in the inheritance of chronic lymphocytic leukaemia and related lymphoproliferative diseases published in Leukemia and Lymphoma. www.Slidesonline.org , by invitation, (Medical Online Digital Library, US), 2008
  

• Jønsson V, Samuelsen SO, Tjønnfjord GE, Johannesen TB. Looking for CLL genes. Leukemia & Lymphoma 2008; 49: 10-11
  

• Johannesen TB, Ly B, Samuelsen SO, Tjønnfjord GE, Jønsson V. Nye studier om kronisk lymfatisk leukemia i Norge. Tidsskr Nor Lægeforening 2008; 128: 713
  

• Olsen AL, Johannesen TB, Ly B, Samuelsen SO, Tjønnfjord G, Jønsson V. Pleiotropy in families with chronic lymphocytic leukemia, and Pleiotropia en familias con leukemia linfocittica cronica. Salud(i)Ciencia (Buenos Aires) 2008;15:1236-41
  

• Jønsson V, Tjønnfjord GE, Johannesen TB, Samuelsen SO, Ly B. Possible imprinting and microchimerism in chronic lymphocytic leukemia and related lymphoproliferative disorders. Translational Oncogenomics 2008, 3: 1-6
  

• Kolstad A, Tjønnfjord G, Jønsson V. High frequency of unrecognized indolent hematological disorders among HLA-matched siblings of patients with lymphoproliferative malignancies eligible for allogeneic stem cell transplantation. Bone Marrow Transplant, 2008; 42:427-8
  

• Crowther D, Wild R, Sellick G, Dyer MJS, Mauro FR, Cuthbert JG, Jønsson V, Matutes E, Dearden C, Wiley J, Fuller S, Catovsky D, Houlston RS. Insight into the pathogenesis of chronic lymphocytic leukemia (CLL) through analysis of IgVH gene usage and mutation status in familial CLL. Blood 2008; 111: 5691-93
  

• Jønsson V, Johannesen TB, Samuelsen SO, Ly B, Bock J, Tjønnfjord GE. Aspectos geneticos de la leukemia linfocitica cronica. Salud Cienia (Buenos Aires) 2008; 16:1318
  

• Jønsson V. Birth order effect in the inheritance of chronic lymphocytic leukemia. Anticancer Res 2008; 5C, 3337 a
  

• Jønsson V, Awan H, Johannenesen T, Tjønnfjord G. Birth order effect in the inheritance of CLL. Haematologica 2009; supp. 3, s2
  

• Jønsson V, Christensen BE. Jern, B-vitaminer og medikamentell knoglemarvspåvirkning. In Kampmann JP, Brøsen K, Simonsen U (eds) Basal og Klinisk Farmakologi, 4. udgave, København, FADL´s Forlag, 2009, in press.

Other information

• Contact Dr Jonsson
  

See latest call for papers for Translational Oncogenomics

Author interview with Dr Jean-Claude Debouzy

Dr Debouzy is the author of Study of Alkylglycerol Containing Shark Liver Oil: a Physico Chemical Support for Biological Effect? which was recently published in Drug Target Insights.

The Editor in Chief of Drug Target Insights recently issued a call for papers.

Dr Debouzy is a member of our favorite author program. Under the program authors are eligible to receive: prioritised peer review, prioritised author PDF, and an article processing fee discount. All former authors are eligible to join the favorite author program.

What is the primary focus of your research?

Membrane biophysics; NMR; non ionizing radiations drug-membrane interactions.

What are the most exciting developments arising from current research in your area?

Biological effects of electromagnetic radiations.

Who are your main collaborators? Please describe your work with them

• David Crouzier, PhD; ESR studies, oxidative stress, non ionizing radiations, environmental toxicology
  

• Florence Fauvelle, PhD; NMR and metabolomics
  

• Sebastien Follot, PhD; antiapoptotic drugs, proteomics, genomics

How did you come to be working in your research area?

I was MD first, then I undertook a thesis in biophysics, including spectroscopic methods (NMR), antiviruses drugs and membrane biophysics. My intitution asked me to focus more on electromagnetic fields' biological effects.

What do you think about the development of open access publishing? What motivated you to use it?

Very favorable. This is a promising way for information exchange and knowledge improvement.

What articles and/or books have you published recently?

• Vignal R, Crouzier D, Dabouis V, Debouzy JC. Effects of mobile phones and radar radiofrequencies on the eye, Pathol biol, 2009, 57 (6) : 503-508
  

• Follot S, Debouzy JC, Crouzier D, Engherard-Gueiffier C, Gueiffier A, Nachon F, LeFevbre B, Fauvelle F. Physicochemical properties and membrane interactions of anti apoptotic derivatives (4-fluorophenyl)-3-(pyridine-4-yl)imidazo-[1,2-a]pyridine depend on the (4-Hydroxy-alkyl-amino-2) side chain length and conformation : A NMR and ESR study, Eur Med Chem, 2009, 44 (9): 3509-3518
  

• Crouzier D, Perrin A, Torres G, Dabouis V and Debouzy JC. Pulsed electromagnetic fields at 9.71GHz increase free radical production in yeast, Pathol biol, 2009, 57 (3) :245-251
  

• Portier K, Crouzier D, Guichardant m, Debouzy JC, Fellman N, Coudert J. Low and high inspired fraction of oxygen during two hours anaesthesia: Part II : effect on blood viscosity, skeletal muscle blood flow and oxygenation in horses. Veterinary Anesthesia and Analgesia, 2009, 36 (4) : 287-298
  

• Dabouis V, Chancerelle Y, Crouzier D, Debouzy JC. What’s new in biomedical application for Terahertz (THz) technology, Med Sci, 2009, 25 (8-9): 739-743

See latest call for papers for Drug Target Insights

Author Interview with Dr Takemi Otsuki

Dr Otsuki is the author of Immunological changes in mesothelioma patients and their experimental detection which was recently published in Clinical Medicine: Circulatory, Respiratory and Pulmonary Medicine.

The Editor in Chief of Clinical Medicine: Circulatory, Respiratory and Pulmonary Medicine recently issued a call for papers.

Dr Otsuki is a member of our favorite author program. Under the program authors are eligible to receive: prioritised peer review, prioritised author PDF, and an article processing fee discount. All former authors are eligible to join the favorite author program.

What is the primary focus of your research?

Immunological effects of silica/asbestos.

What are the most exciting developments arising from current research in your area?

The discovery of regulatory T cell anf Th17 cell.

Who are your main collaborators? Please describe your work with them

Dr. Takashi Kishimoto; Prof. Takashi Nakano.

How did you come to be working in your research area?

My former boss was working on it.

What articles and/or books have you published recently?

• Nishimura Y, Miura Y, Maeda M, KUmagai N, Murakami S, Hayashi H, Fukuoka K, Nakano T, Otsuki T. Impairment in cytotoxicity and expression of NK-cell activating receptors on human NK cells following exposure to asbestos fibers. Int J Immunopathol Pharmacol 2009 Jul-Sep;22(3):579-90
  

• Nishimura Y, Maeda M, Kumagai N, Hayashi H, Miura Y, Otsuki T. Decrease in phosphorylation of ERK following decreased expression of NK-cell activating receptors in human NK cell line exposed to asbestos. Int J Immunopathol Pharmacol (in press)
  

• Hayashi H, Maeda M, Murakami S, Kumagai N, Chen Y, Hatayama T, Katoh M, Miyahara N, Yamamoto S, Yoshida Y, Nishimura Y, Kusaka M, Fujimoto W, Otsuki T. Soluble interleukin-2 receptor as an indicator of immunological disturbance found in silicosis patients Int J Imminopathol Pharmacol 2009 Jan-Mar;22(1):53-62
  

• Takahashi K, Otsuki T, Mase M, Kawado T, Kotani M, Nishimura Y, Maeda M, Murakami S, Kumagai N, Hayashi H, Chen Y, Shirahama T, Miura Y, Morimoto K. Two weeks of abidance in negatively-charged air conditions causes alteration of natural killer cell function. Int J Immunopathol Pharmacol 22(2); 333-342, 2009
  

• Murakami S-i, Otsuki T, Maeda M, Miura Y, Morii S, Kiyokane K, Hayakawa S-i, Maeda A, Imakawa T, Harada S, Handa T, Nishimura Y, Murakami S, Kumagai N, Hayashi H, Chen Y, Suemori S-i, Fukushima Y, Nishida S,Fukushima K. Effects of Vitamin D receptor (VDR) gene polymorphism on low-resistance training using exercise machines (“Power rehabilitation”) as rehabilitation program. Int J Mol Med. 2009 Jan;23(1):81-8
  

• Otsuki T. Biological effects of fibrous and particulated substances and related areas: foreword. (Special Features: Biological effects of fibrous and particulated substances and related areas). Environ Health Prev Med214-215; 2009
  

• Murakami S, Nishimura Y, Maeda M, Kumagai N, Hayashi H, Chen Y, Kusaka K, Kishimoto T, Otsuki t. Cytokine alteration and speculated immunological pathophysiology in silicosis and asbestos-related diseases. Environ Health Prev Med 14(4): 216-222, 2009
  

More information

• Contact Dr Otsuki

• Kawasaki Medical School, Dept of Hygiene

See latest call for papers for Clinical Medicine: Circulatory, Respiratory and Pulmonary Medicine

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Author interview with Dr Kazuyoshi Tsutsui

Dr Kazuyoshi Tsutsui is the author of Neurosteroid Biosynthesis and Action in the Purkinje Cell which was recently published in Journal of Experimental Neuroscience.

The Editor in Chief of Journal of Experimental Neuroscience recently issued a call for papers.

Dr Tsutsui is a member of our favorite author program. Under the program authors are eligible to receive: prioritised peer review, prioritised author PDF, and an article processing fee discount. All former authors are eligible to join the favorite author program.

What is the primary focus of your research?

Probing undiscovered neurohormones, such as neuropeptides and neurosteroids, that play important roles in the regulation of brain function in vertebrates is essential for the progress of neuroendocrinology and neurobiology. To open the door to a new research field in neuroendocrinology and neurobiology, my main research over the past decade has been focusing on the discovery of novel neurohormones and the demonstration of their mode of action and functional significance.

What are the most exciting developments arising from current research in your area?

Our studies over the past decade by focusing on novel neuropeptides and neurosteroids have uncovered several “firsts” and contributed to the progress of neuroendocrinology and neurobiology.

In 1995, we first found de novo neurosteroidogenesis in the avian brain from cholesterol and subsequently demonstrated the biosynthetic pathway of neurosteroids in birds. We also discovered that the Purkinje cell, an important brain neuron, is a major site for neurosteroid formation in the brain of a variety of vertebrates. This discovery has allowed deeper insights into neuronal neurosteroid formation and diverse actions of neurosteroids have become clear by our studies using the Purkinje cell as an excellent cellular model, which is known to play an important role in memory and learning processes. The promotion of neuronal growth, spinogenesis and synaptogenesis and the modulation of synaptic neurotransmission by neurosteroids have been demonstrated.

We have further identified 7alpha-hydroxypregnenolone as a novel bioactive neurosteroid in the brain of vertebrates. 7alpha-Hydroxypregnenolone acts as a key factor for induction of locomotor activity of vertebrates and melatonin regulates synthesis of this neurosteroid, thus inducing diurnal locomotor changes of vertebrates.

In 2000, we discovered GnIH as a novel hypothalamic neuropeptide in birds. The neuropeptide gonadotropin-releasing hormone (GnRH) is known to be the primary factor responsible for the hypothalamic control of gonadotropin secretion. However, an inhibitory neuropeptide of gonadotropin secretion was, until recently, unknown in any vertebrate. Subsequently, we demonstrated that GnIH inhibits gonadal development and maintenance by decreasing gonadotropin synthesis and release in birds. It is also becoming clear that a similar gonadotropin-inhibitory system is present in mammals including primates and humans. Thus, the discovery of GnIH has opened a new research field in reproductive neuroendocrinology from a novel standpoint.

Who are your main collaborators? Please describe your work with them

To discover novel neuropeptides and neurosteroids and demonstrate their mode of action and functional significance in vertebrates, I am collaborating with a number of eminent scientists throughout the globe, such as: Drs. Hubert Vaudry (France); Etienne E. Baulieu (France); Peter J. Sharp (UK); Robert W. Lea (UK); Robert P. Millar (UK); John C. Wingfield (USA); Stacia A. Sower (USA); Pierre Deviche (USA); Lance J. Kriegsfeld (USA); George E. Bentley (USA); Mary Ann Ottinger (USA); Rae Silver (USA); Stuart Tobet (USA); Pat Johnson (USA); Heike Muenzberg (USA); W. R. Butler (USA); Clay Lents (USA); Ei Terasawa (USA); Barbara Karten (Canada); Iain J. Clarke (Australia); John Cockrem (New Zealand); Vinod Kumar (India); Kyungjin Kim (Korea); Sakae Kikuyama (Japan); Hiroshi Kawauchi (Japan); Hitoshi Okamura (Japan); Yoshitaka Fukada (Japan); Mitsuhiro Kawata (Japan); and Yoshitaka Nagahama (Japan).

How did you come to be working in your research area?

How can a scientist contribute to the progress of neuroendocrinology and neurobiology? My answer is "start from zero" to create a new way in neuroendocrinology and neurobiology. Therefore, I first looked for undiscovered neurohormones, such as neuropeptides and neurosteroids, in the brain of vertebrates and then analyzed their mode of action and functional significance.

What do you think about the development of open access publishing? What motivated you to use it?

The development of open access publishing has allowed the easy access of manuscripts. It has also expanded the type of manuscript we can access. I have published in several open access journals including Journal of Experimental Neuroscience. Open access publishing is changing our way of thinking and working.

What articles and/or books have you published recently?

I have published recently several review papers in the first rank journals including Progress in Neurobiology, Frontiers in Neuroendocrinology, Mass Spectrometry Reviews, Endocrinology, Molecular Neurobiology and Journal of Experimental Neuroscience. I have also published an impressive set of original papers in journals including Nature Medicine, Proceedings of National Academy of Sciences of United States of America, Journal of Neuroscience, Journal of Neurochemistry, Neuroscience and Endocrinology.

I have edited recently the book Trends in Comparative Endocrinology by the Asia and Oceania Society for Comparative Endocrinology and the Japanese Society for Comparative Endocrinology.

Further information

• The Society for Integrative & Comparative Biology website

• European Society for Comparative Endocrinology website
  

• The Japanese Society for Comparative Endocrinology website
  

• Society for Neuroscience website
  

• Society for Research on the Cerebellum website
  

• Contact Dr Tsutsui

See latest call for papers for Journal of Experimental Neuroscience

Pubmed indexing for Bioinformatics and Biology Insights

Bioinformatics and Biology Insights is now indexed by Pubmed.

Bioinformatics and Biology Insights is a highly successful journal which combines:

Visibility

The journal is indexed by:

• Pubmed
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The most read article published in 2009 has been read over 1000 times, and most articles have been read over 500 times.

Libertas Academica articles are downloaded 4,996 times per month. Individual articles are viewed up to 8,000 times and cited up to 1,000 times.

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First editorial decision in 2 weeks.

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Editor in Chief Dr Erich Bornberg-Bauer and Associate Editor Dr Rainier Breitling ensure that the journal combines fast service to authors with high standards of editorial integrity.

• Bioinformatics and Biology Insights home page
  
  
• Editor in Chief's latest call for papers
  

Author Interview with Dr Mirna Waked

Dr Waked is the author of Saliva Cotinine and Exhaled Carbon Monoxide in Real Life Waterpipe Smokers: A Post Hoc Analysis which was recently published in Tobacco Use Insights.

The Editor in Chief of Tobacco Use Insights recently issued a call for papers.

Dr Waked is a member of our favorite author program. Under the program, authors are eligible to receive: prioritised peer review, prioritised author PDF, and an article processing fee discount. All former authors are eligible to join the favorite author program.

Please describe your experience with Libertas Academica

I found a highly positive, professional attitude and seriousness in publishing my articles in Libertas Academica. I am confident in future collaboration.

What is the primary focus of your research?

Clinical issues in respiratory medicine.

What are the most exciting developments arising from current research in your area?

Phenotypes and genotypes in asthma, pollution effect on chronic respiratory diseases, COPD, epidemiology and comorbidities.

Who are your main collaborators? Please describe your work with them.

Dr Pascale Salameh, epidemiologist, PHD Pharmacy: highly intelligent and full of initiative.

How did you come to be working in your research area?

Starting my fellowship in pulmonary disease, I felt very attracted to the field. In France I had the opportunity to publish with big names. In Lebanon, I found more difficulty starting my own initiatives. But in my curriculum this was a great job to do.

What do you think about the development of open access publishing? What motivated you to use it?

The big and well known reviews and journals are becoming highly selective on the topics and scope. It needs a huge effort to get a paper inserted in these big referenced publishing organisations. It is very important to us to get easy access to publish in serious, well managed reviews.

What articles and/or books have you published recently?

• Waked M; Salameh P. Risk factors of asthma and allergic diseases in 5-14y old Lebanon School Children. Journal of Asthma and Allergy 2009; 2: 1-7.


• Waked M, Salameh P, Aoun Z. Water-pipe Smokers in Lebanon: A pilot study. Eastern Mediterranean Health Journal, Journal 2009; 15(2): 432-442.


• Salameh P, Aoun Bacha Z, Waked M. Saliva Cotinine and Exhaled Carbon Monoxide in Real Life Water pipe Smokers: A post hoc analysis. Tobacco Use Insight, Tobacco Use Insights 2009:2, 1–10.


• A. Taher, P. Salameh, G. Dabar, Waked M, et al. The AVAIL ME project: a first regional evaluation of venous thromboembolism (VTE) risk and prophylaxis practice. Abstract submitted for the XXII Congress of the International Society on Thrombosis and Haemostasis, taking place in Boston, USA from July 11 to 16, 2009.
  
  
• Kreidy R, Waked M, Stephan E, Jureidini I, Irani-Hakime N. Contribuation of factor VR506Q-Leiden, prothrombin g 20210a and MTHFR C 677T mutation to the genetic susceptibility of deep vein thrombosis of lower extremities. Is screening for factor V H 1299 R and MTHFR A 1298 C justified? International Angiology 2009: 28 supp 1 number 4.

Further information

• Contact Dr Waked

See latest call for papers for Tobacco Use Insights

Author interview with Dr Hiro Koshiyama

Dr Koshiyama is the author of Diabetes Mellitus as Dysfunction of Interactions Among all Organs: “Ominous Orchestra of Organs” which was recently published in Clinical Medicine: Endocrinology and Diabetes.

The Editor in Chief of Clinical Medicine: Endocrinology and Diabetes recently issued a call for papers.

Dr Koshiyama is a member of our favorite authors program. Under the program authors are eligible to receive: prioritised peer review, prioritised author PDF, and an article processing fee discount. All former authors are eligible to join the favorite author program.

Please describe your experience with Libertas Academica

My experience with Libertas Academica was excellent. The review process was smooth and speedy. After publishing, I received a kind and favorable response from a reader. I have never experienced such a comment after my publications to orthodox journals.

What is the primary focus of your research?

My primary focus is clinical endocrinology and diabetes mellitus, especially in relation to its macrovascular complications.

What are the most exciting developments arising from current research in your area?

I think that the effectiveness of incretin analog and/or enhancer in Japanese type 2 diabetes is one of the exciting topics.

Who are your main collaborators?

Emeritus Professor Yutaka Seino.

How did you come to be working in your research area?

After I entered Professor Imura's Lab at the Postgraduate School of Medicine, Kyoto University.

What do you think about the development of open access publishing? What motivated you to use it?

I think that it will enable us to collaborate with other researchers. In this era, I think that the sharing of data and concepts should be more open.

What articles and/or books have you published recently?

• Koshiyama H, Taniguchi A, Tanaka K, Kagimoto S, Fujioka Y, Hirata K, Nakamura Y, Iwakura A, Hara K, Yamamoto T, Kuroe A, Ohya M, FujimotoS, Hamamoto Y, Honjo S, Ikeda H, Nabe K, TsudaK, Inagaki N, Seino Y, Kume N. Effects of pitavastatin on lipid profiles and high-sensitivity CRP in Japanese subjects with hypercholesterolemia :Kansai Investigation of Statin for Hyperlipidemic Intervention in Metabolism and Endocrinology (KISHIMEN) Investigators. Journal of Atherosclerosis and Thrombosis 2008; 15(6): 345-350

• Ikeda H, Nakamura Y, Minamikawa J, Honjo S, Hamamoto Y, Wada Y, Nabe K, Koshiyama H. Comparison of Effects of Amlodipine and Angiotensin Receptor Blockers on the Intima-media Thickness of Carotid Arterial Wall (AAA Study: Amlodipine vs ARB in Atherosclerosis Study) Diabetes Res Clin Pract 2009; 83:117-50-53

• Ikeda H, Honjo S, Hamamoto Y, Wada Y, Nabe K, Koshiyama H. Olmesartan reduced microalbuminuria in Japanese subjects with type 2 diabetes. Diabetes Res Clin Pract 2009; 83: 117-118.

• Kimura T, Ikeda H, Fujikawa J, Nomura K, Aoyama T, Nabe K, Hamamoto Y, Honjo S, Koshiyama H. Usefulness of serum cystatin C as a marker of diabetic nephropathy in Japanese subjects with type 2 diabetes. Diabetes Res Clin Pract 2009 83(2):e58-61.

• Koshiyama H, Ogawa Y, Tanaka K, Tanaka I. Integrated Network Systems and Evolutionary Developmental Endocrinology. Medical Hypotheses 2009.

• Honjo S, Ikeda H, Kawasaki Y, Wada Y, Hamamoto Y, Aoyama T, Kimura T, Nomura K, Koshiyama H. Efficacy and safety of miglitol:switching study from voglibose in Japanese patients with type 2 diabetes. The Open Diabetes Journal 2009;2:60-61
  

• Nishi Y, Koshiyama H, Honjo S, Seino Y. Poor Correlation of pulse wave velocity and intima-media thickness in diabetic subjects (letter). Diabetes Care 2004;
  
  
• 27(8):2084.Koshiyama H, Ikeda H, Honjo S, Nakamura Y, Tanaka K, Tsugawa N, Okano T. Hypovitaminosis D is frequent in Japanese subjects with type 2 diabetes (letter). Diabetes Res Clin Pract 2007;76:470-1Koshiyama H, Inagaki N, Seino Y. Which we should ADOPT: sulfonylureas or glitazones?(letter) Diabetic Medicine 2007; 24(7):804

More information

• Contact Dr Koshiyama

• Center for Diabetes and Endocrinology
  

See latest call for papers for Clinical Medicine: Endocrinology and Diabetes

Author Interview with Dr Jagannadham

DrJagannadham is the author of Detecting the site of phosphorylation in phospho peptides without loss of phosphate group using MALDI TOF mass spectrometry which was recently published in Analytical Chemistry Insights.

The Editor in Chief of Analytical Chemistry Insights recently issued a call for papers.

Dr Jagannadham is a member of our favorite author program. Under the program authors are eligible to receive: prioritised peer review, prioritised author PDF, and an article processing fee discount. All former authors are eligible to join the favorite author program.

Please describe your experience with Libertas Academica

Libertas Academica is author friendly, particularly in communicating with the authors quickly on the progress of publishing process. It engages scientists nicely with their timely e-mail alerts.

I appreciate and encourage the efforts of Libertas Academica for their efforts in open access publications. I am sure that it is (open access publication) here to stay in the years to come.

What is the primary focus of your research?

I am working in proteomics, particularly on posttranslational modifications of proteins and also on the membrane proteins of a Gram-negative Antarctic bacterium. My research activities also involve studies on the outer membrane vesicles (OMV) of gram –ve bacteria. OMVs are proteo-lipids, known to transport molecules to prokaryotic and eukaryotic cells through a process of membrane fusion. Since these vesicles are reported to possess a role in transport of various molecules among cells, it is possible that the information on their structure will enable to design transporters.

What are the most exciting developments arising from current research in your area?

I am designing molecular transporters (protein, DNA, and other molecules) taking clues from the structural studies on the outer membrane vesicles of gram –ve bacteria.

Who are your main collaborators? Please describe your work with them

Besides Dr R Nagaraj, a senior scientist at the Centre for cellular and Molecular Biology, Hyderabad, my collaborators include Dr K Sankaran , Anna University, Chennai and Dr Anil K Tripathi, Department of Biotechnology, Banaras Hindu University, Varanasi, India. I am collaborating with Dr Nagaraj and Dr Sankaran on identification of posttranslational modifications of proteins. I worked on the function of carotenoids in bacteria and Dr Tripathi collaborated with me in this work. I am open to collaborations in proteomics.

How did you come to be working in your research area?

I started my service career at the facility group of CCMB. Here I was assigned the works on protein sequencing, amino acid analysis and HPLC analysis of various samples. While continuing my research in this area, I also involved myself in studies on the role of carotenoid pigments in cold tolerance of some Antarctic bacteria, sampled from the South Pole by Dr S.Shivaji, scientist, CCMB and subsequently characterized by his research team. Working on this project under his guidance I got a PhD from Jawaharlal Nehru University, New Delhi, India. Subsequently with the help of Dr R Nagaraj, a renowned protein chemist, I started working in protein chemistry.

What do you think about the development of open access publishing? What motivated you to use it?

Development of open access publishing is highly desirable and should be encouraged in the interest of science. Appropriate provisions should be incorporated wherever required in this process to protect intellectual property rights. I am thankful to Dr Tom Hill for his invitation to publish in Analytical Chemistry Insights.

A thorough discussion on IPR related issues for open access publications is desirable. In the competitive environment of scientific research, middle level researchers should get sufficient encouragement to publish open access publications. Middle level scientists are preferring to publish in well established high impact factor journals. These are two important issues I can think of on the spot.

What articles and/or books have you published recently?

• Jagannadham M V (2008) Identification of proteins from membrane preparations by a combination of MALDI TOF-TOF and LC coupled linear ion trap MS analysis of an Antarctic bacterium Pseudomonas syringae Lz4W , a strain with unsequenced genome. Electrophoresis. 29: 4341-4350
  

• Yadav, S.C; Jagannadham, M.V; Kundu,S and Jagannadham M.V. (2009) A kinetically stable plant subtilase with unique peptide mass fingerprints and dimerization properties.Bio Phys Chem.139:13-23
  

• Mala.G; Paithankar, K.R; Jagannadham M.V; Sundaram.C.S; Murthy,B.S.N and Lalji Singh. (2007) Characterization of novel DNA-binding proteins expressed in snake oocyte cDNA library. Protein Expr. Purif 53: 164-178
  

• Jagannadham M.V and Nagaraj. R (2005) Conformation of Gramicidin A in water: inference from analysis of hydrogen/ deuterium exchange behavior by MALDI mass spectrometry. Biopolymers. 80: 708-713
  

• Jagannadham M.V and Nagaraj R (2005) Detection of peptides covalently modified with multiple fatty acids by MALDI TOF mass spectrometry. J Pep Res 66: 94-100.

• Jagannadham MV (2009) Identifying the sequence and distinguishing the oxidized methionine from phenylalanine peptides by MALDI TOF/TOF mass spectrometry in an Antarctic bacterium Pseudomonas syringae. Proteomics insights.2:27-31.

Other information

• The Centre for Cellular and Mollecular Biology

• Contact Dr Jagannadham

See latest call for papers for Analytical Chemistry Insights

Author Interview with Dr Pascale Salameh

Dr Salameh is the author of Saliva Cotinine and Exhaled Carbon Monoxide in Real Life Waterpipe Smokers: A Post Hoc Analysis which was recently published in Tobacco Use Insights.

The Editor in Chief of Tobacco Use Insights recently issued a call for papers.

Dr Salameh is a member of our favorite author program. Under the program authors are eligible to receive: prioritised peer review, prioritised author PDF, and an article processing fee discount. All former authors are eligible to join the favorite author program.

Please describe your experience with Libertas Academica

I had a very pleasant experience. One of the most efficient and rapid publication processes. Good luck!!

What is the primary focus of your research?

Epidemiology of chronic diseases in Lebanon, mainly respiratory diseases.

What are the most exciting developments arising from current research in your area?

The scoring of waterpipe dependence.

Who are your main collaborators? Please describe your work with them

Professor Mirna Waked: she is a pulmonologist; we have been working together since 1999; she handles the clinical part (including medical writing), and I take care of the field work and statistical analysis.

What do you think about the development of open access publishing? What motivated you to use it?

I was thrilled by the idea of higher exposure.

What articles and/or books have you published recently?

• Salameh P, Barbour B. Pattern of Obesity and associated diabetes in Lebanese school adolescents: A pilot study. East Mediterranean Health Journal 2009. Accepted, under press.


• Issa C, Salameh P, Batal M, Vieux F, Lairon D, Darmon N. The nutrient profile of traditional Lebanese composite dishes : comparison with composite dishes consumed in France. International Journal of Food Sciences and Nutrition 2009 ; S1-S10.


• Bou Antoun R, Salameh P. La satisfaction des pharmaciens au Liban et la perspective de la pharmacie clinique. East Mediterranean Health Journal 2009 ; 12(6).


• Saadé N, Salameh P, Barbour B. Congé maternel et mères travailleuses au Liban : circonstances professionnelles. Sciences Sociales et Santé. Accepted 2009, under press.
  
• Barbour B, Salameh P. Consanguinity in Lebanon: prevalence, distribution and determinants. Journal of Biosocial Sciences 2009; 41(4): 505-17.


• Waked M, Salameh P. Asthma risk factors distribution in Lebanese children. Journal of Asthma and Allergy 2008; 2: 1-7.


• Farra C, Nassar AH, Usta IM, Salameh P, Souaid M, Awwad J. Acceptance of preimplantation genetic diagnosis for beta-thalassemia in Lebanese women with previously affected children. Prenat Diagn. 2008 ; 28(9): 828-32.


• Waked M, Salameh P. Asthma, Allergic Rhinitis and Eczema in 5-12 year old school children across Lebanon. Public Health 2008; 122(9): 965-73.


• Waked M, Salameh P. Symptoms, Severity and Asthma Control in 5-14 old Lebanon School Children. Lebanese Medical Journal 2007. 55(3) : 145-151.


• Salameh P, Najjar Aad M, Semaan M, El Hawzi R, Bechara M, El Kadi B, Bou Tanios L. Le circuit du médicament dans les hôpitaux Libanais. Epidemiology and Public Health 2007; 55(4) :308-13.

See latest call for papers for Tobacco Use Insights

Author interview with Dr Akimune Fukushima

Dr Fukushima is the author of Assessment of Fetal Autonomic Nervous System Activity by Fetal Magnetocardiography which was recently published in Clinical Medicine: Cardiology.

The Editor in Chief of Clinical Medicine: Cardiology recently issued a call for papers.

Dr Fukushima is a member of our favorite author program. Under the program authors are eligible to receive: prioritised peer review, prioritised author PDF, and an article processing fee discount. All former authors are eligible to join the favorite author program.

What is the primary focus of your research?

Evaluating the fetal autonomic nervous system developement with non-invasive technology such as magnetocardiography (MCG).

What are the most exciting developments arising from current research in your area?

Fetal magnetocardiography(FMCG) was the most exciting development.

Who are your main collaborators? Please describe your work with them

Dr. Kenji Nakai who is the cardiologist. He did most of the FMCG arrengements.

How did you come to be working in your research area?

My main work is the clinical Obstetrics. Prenatal diagnosis and assesment of the fetus are the most important part of my job. I am also interseted in non-invasive technology. From both standpoint of view, I started to join this research area.

What do you think about the development of open access publishing? What motivated you to use it?

I was very impressed with the quick response from the editor.

What articles and/or books have you published recently?

• Prenatal Diagnosis of Recurrent Ventricular Tachycardia using 64-channel Magnetocardiography; Heart and Vessels (2009) in press
  

Other information

• Contact Dr Fukushima

See latest call for papers for Clinical Medicine: Cardiology

Author interview with Dr Bonnie Kaplan

Dr Kaplan is the author of Database Analysis of Adults with Bipolar Disorder Consuming a Micronutrient Formula which was recently published in Clinical Medicine: Psychiatry.

The Editor in Chief of Clinical Medicine: Psychiatry recently issued a call for papers.

Dr Kaplan is a member of our favorite author program. Under the program authors are eligible to receive: prioritised peer review, prioritised author PDF, and an article processing fee discount. All former authors are eligible to join the favorite authors program.

What is the primary focus of your research?

Nutrition's effects on brain development and function.

What are the most exciting developments arising from current research in your area?

The possibility of treating serious physical and mental problems with nutrient supplementation instead of medications.

How did you come to be working in your research area?

I have had a longstanding interest in nutrition; my research is on brain development and function. Blending the two is logical.

What articles and/or books have you published recently?

• Gately, D., Kaplan, B.J. (2009). Database analysis of adults with bipolar disorder consuming a micronutrient formula. Clinical Medicine: Psychiatry, 4:3-16
  

• Rucklidge, J. J., Johnstone, J., & Kaplan, B. J. (2009). Nutrient supplementation approaches in the treatment of ADHD. Expert Review of Neurotherapeutics, 9(4):461-476
  

• Leung, B., Kaplan, B.J. (2009). Perinatal depression: prevalence, risks and the nutrition link – a review of the literature. Journal of the American Dietetic Association, 109:1566-1575

See latest call for papers for Clinical Medicine: Psychiatry

Author Interview with Dr Jeanne Adiwinata Pawitan

Dr Pawitan is the author of Melamine contaminated food: serious threat to our health which was recently published in Primary Prevention Insights.

The Editor in Chief of Primary Prevention Insights recently issued a call for papers.

Dr Pawitan is a member of our favorite author program. Under the program authors are eligible to receive: prioritised peer review, prioritised author PDF, and an article processing fee discount. All former authors are eligible to join the favorite author program.

Please describe your experience with Libertas Academica

I really did not expect that I would get a fast response, as happened with my first experience with LA. Moreover, the staff are very helpful, and the peer reviewers gave very useful comments that make my paper more interesting and readable.

What is the primary focus of your research?

Now I am planning to begin stem cell research.

What are the most exciting developments arising from current research in your area?

Stem cells can be used in various areas of regenerative medicine.

Who are your main collaborators? Please describe your work with them

Dr Arleni, MBiomed cultures the stem cells. Radiana Antarianto, MD, MBiomed identifies the cells using IHC. Lia Damayanti, MD, MBiomed, Pathologist also identifies the cells using IHC.

How did you come to be working in your research area?

My department has decided to focus on this research.

What do you think about the development of open access publishing? What motivated you to use it?

Open access publishing will get more citation.

What articles and/or books have you published recently?

• Melamine contaminated food: serious threat to our health in Primary Prevention Insights
  
  
• The possible use of RNA interference in diagnosis and treatment of various diseases in The International Journal of Clinical Practice
  

See latest call for papers for Primary Prevention Insights

Author interview with Dr Martina Reiter

Dr Reiter is the author of Gene expression in hair follicle dermal papilla cells after treatment with stanozolol which was recently published in Biomarker Insights.

The Editor in Chief of Biomarker Insights recently issued a call for papers.

Dr Reiter is a member of our favorite author program. Under the program authors are eligible to receive: prioritised peer review, prioritised author PDF, and an article processing fee discount. All former authors are eligible to join the favorite author program.

What is the primary focus of your research?

qPCR analysis: gene expression studies, gene analysis in human tissues.

What are the most exciting developments arising from current research in your area?

Significant gene regulations could be recognized under anabolic steroid treatment, so that first hormone dependent biomarkers could be identified.

Single-cell analysis in qPCR is possible. Detection of single copy numbers possible. First steps toward gene expession studies in single-cells

Who are your main collaborators? Please describe your work with them

TU Munich: gene expression studies in diabetes patients; Advalytix: single cell analysis

How did you come to be working in your research area?

I started to work in this area during my PhD at the TU Munich

What do you think about the development of open access publishing? What motivated you to use it?

It is a good idea. Research results should be available for everybody so that scientific exchanges become better.

What articles and/or books have you published recently?

• Reiter, M.; Walf, V.M.; Christians A.; Pfaffl, M.W.; Meyer, H.H.D.: "Modification of mRNA expression after treatment with anabolic agents and the usefulness for gene expression-biomarkers". Analytica Chimica Acta 586 (2007) 73-81
  

• Reiter, M.; Pfaffl, M.: "Effects of plate position, plate type and sealing systems on real-time PCR results". Biotechnology & Biotechnological Equipment 22 (2008) 824-828
  

• Reiter, M.; Pfaffl, M.W., Schönfelder, M.; Meyer, H.H.D.: "Gene expression in hair follicle dermal papilla cells after treatment with stanozolol". Biomarker Insights 4 (2009) 1-8
  

• M. Reiter1, S. Lüderwald2, M.W. Pfaffl1, H.H.D. Meyer1: "First steps towards a new screening method for anabolic androgenic agents in human hair follicle". The Doping Journal Vol. 5, 3 (2008)
  

• Reiter, M.; Riedmaier, I., Pfaffl, M.W., Meyer, H.H.D.: "Monitoring gene expression in muscle tissue of macaca fascicularis under the influence of testosterone and SARM". Hormone Molecular Biology and Clinical Investigation (2009)
  

Other information

• Dr Reiter is CEO of BioEPS
  

• Contact Dr Reiter
  

See latest call for papers for Biomarker Insights