Friday, September 5, 2014

Published This Week (1st - 5th September 2014)_

We are pleased to announce the publication of the following peer reviewed papers. Sign up to receive email alerts to receive immediate notification of new papers.

Bioinformatics and Biology Insights
Integrated Analysis of Dysregulated miRNA-gene Expression in HMGA2-silenced Retinoblastoma Cells

Biomarker Insights
Increased Expression of Phosphorylated FADD in Anaplastic Large Cell and Other T-Cell Lymphomas

Clinical Medicine Insights: Case Reports
Mycosis Fungoides: Case Report and Literature Review

Osteonecrosis of the Femoral Head with Collapsed Medial Lesion

Concealed Sinus Node Dysfunction and Paradoxical Effect of Atropine during Arrhythmia Diagnostic Pharmacological Testing

Syringomyelia Associated with Spinal Arachnoiditis Treated by Partial Arachnoid Dissection and Syrinx-Far Distal Subarachnoid Shunt

Three Cases of Immature Teratoma Diagnosed after Laparoscopic Operation

Clinical Medicine Insights: Oncology
Tandem Autologous Stem Cell Transplantation for Multiple Myeloma Patients Based on Response to Their First Transplant-A Prospective Phase II Study

Clinical Medicine Insights: Pediatrics
Factors Associated with Delayed Cancer Diagnosis in Egyptian Children

Genomic Insights
Reassessment of the Genome Size in Elaeis guineensis and Elaeis oleifera, and Its Interspecific Hybrid

Microbiology Insights
Limitations of Using Propidium Monoazide with qPCR to Discriminate between Live and Dead Legionella in Biofilm Samples

 

Friday, August 29, 2014

Published This Week (25th - 29th August)

We are pleased to announce the publication of the following peer reviewed papers. Sign up to receive email alerts to receive immediate notification of new papers.

Air, Soil, and Water Research
Removal of Cd(II) Ions from Simulated Wastewater by HCl Modified Cucumis sativus Peel: Equilibrium and Kinetic Study

Clinical Medicine Insights: Cardiology
Echocardiographic Assessment of Mitral Valve Regurgitation, Pattern and Prevalence, Expanding Clinical Awareness Through an Institutional Survey with the Perspective of a Quality Improvement Project

Distinct Mitral Valve Proteomic Profiles in Rheumatic Heart Disease and Myxomatous Degeneration

Clinical Medicine Insights: Case Reports
SMA Syndrome Treated by Single Incision Laparoscopic Duodenojejunostomy

Clinical Medicine Insights: Oncology
Update on the Use of l-Asparaginase in Infants and Adolescent Patients with Acute Lymphoblastic Leukemia

Clinical Medicine Insights: Pediatrics
Clinical Options for the Treatment of Urinary Tract Infections in Children

Indian Journal of Clinical Medicine
Morbidity Pattern and Outcome of Patients Admitted into a Pediatric Intensive Care Unit in India

Journal of Central Nervous System Disease
Molecular Network Analysis Suggests a Logical Hypothesis for the Pathological Role of C9orf72 in Amyotrophic Lateral Sclerosis/Frontotemporal Dementia

Journal of Medical Education and Curricular Development
Food for Thought: The Process of Bringing a Universal Medical Curriculum to the Plate – Part I of III

Can Reflective Writing Reconcile ACGME Core Competencies with Daily Encounters in Medical Education? A Prospective, Randomized, Cross-over Pilot Study

Nutrition and Metabolic Insights
Mango Supplementation Improves Blood Glucose in Obese Individuals

Ophthalmology and Eye Diseases
Time-dependent Gene Profiling Indicates the Presence of Different Phases for Ischemia/Reperfusion Injury in Retina

Perspectives in Medicinal Chemistry
Antibiotics and Bacterial Resistance in the 21st Century

Primary Prevention Insights
Obesity Prevention in Children from Birth to Age 5

 

Published During August

We are pleased to announce the publication of the following peer reviewed papers in August.  Sign up to receive email alerts to receive immediate notification of new papers.


Air, Soil and Water Research

Price Elasticity of Water Demand in a Small College Town: An Inclusion of System Dynamics Approach for Water Demand Forecast

Removal of Cd(II) Ions from Simulated Wastewater by HCl Modified Cucumis sativus Peel: Equilibrium and Kinetic Study

Analytical Chemistry Insights
A Continuous Flow System for the Measurement of Ambient Nitrogen Oxides [NO + NO2] Using Rhodamine B Hydrazide as a Chemosensor

Bioinformatics and Biology Insights
Computational Identification of Dengue Virus MicroRNA-Like Structures and their Cellular Targets

Biomarker Insights
Identification of Gene Signatures Used to Recognize Biological Characteristics of Gastric Cancer Upon Gene Expression Data

Cancer Growth and Metastasis
Bone Disease in Multiple Myeloma: Pathophysiology and Management

Cell & Tissue Transplantation & Therapy
Use of Adult Stem Cells for Orthopedic Regenerative Medicine Applications

Clinical Medicine Insights: Blood Disorders
Ribosomopathies: Mechanisms of Disease

Clinical Medicine Insights: Cardiology
Aborted Sudden Cardiac Death and a Mother with Suspected Metabolic Myopathy

Echocardiographic Assessment of Mitral Valve Regurgitation, Pattern and Prevalence, Expanding Clinical Awareness Through an Institutional Survey with the Perspective of a Quality Improvement Project

Distinct Mitral Valve Proteomic Profiles in Rheumatic Heart Disease and Myxomatous Degeneration

Clinical Medicine Insights: Case Reports
SMA Syndrome Treated by Single Incision Laparoscopic Duodenojejunostomy

Cutaneous Necrosis As a Result of Isosulphane Blue Injection in Mammarian Sentinel Lymph Node Mapping: Report of Two Cases

Effect of Vitamin D3 on Untreated Graves’ Disease with Vitamin D Deficiency

Laparoscopic Treatment of Gallstone Ileus

Clinical Medicine Insights: Ear, Nose and Throat
Myringoplasty with and without Cortical Mastoidectomy in Treatment of Non-cholesteatomatous Chronic Otitis Media: A Comparative Study

FDG-PET/CT in the Assessment of Treatment Response after Oncologic Treatment of Head and Neck Squamous Cell Carcinoma

Clinical Medicine Insights: Gastroenterology
Successful Treatment of Severe Spontaneous Periampullary Bleeding with Argon Plasma Coagulation

Clinical Medicine Insights: Oncology
Update on the Use of l-Asparaginase in Infants and Adolescent Patients with Acute Lymphoblastic Leukemia

Clinical Medicine Insights: Pediatrics
Clinical Options for the Treatment of Urinary Tract Infections in Children

Clinical Medicine Insights: Reproductive Health
The Low Prevalence of Y Chromosomal Microdeletions is Observed in the Oligozoospermic Men in the Area of Mato Grosso State and Amazonian Region of Brazilian Patients

Drug Target Insights
Febuxostat for Hyperuricemia in Patients with Advanced Chronic Kidney Disease

Evolutionary Bioinformatics
iteRates: An R Package for Implementing a Parametric Rate Comparison on Phylogenetic Trees

Immunology and Immunogenetics Insights
HLA-A, -B, -C, -DRB1, and -DQB1 Allele Lineages and Haplotype Frequencies among Saudis

Indian Journal of Clinical Medicine
Morbidity Pattern and Outcome of Patients Admitted into a Pediatric Intensive Care Unit in India

International Journal of Insect Science
Potential Positive Effects of Pesticides Application on Sesamia inferens (Walker) (Lepidoptera: Insecta)

Integrative Medicine Insights
Memory Decline in Peri- and Post-menopausal Women: The Potential of Mind–Body Medicine to Improve Cognitive Performance.

Japanese Clinical Medicine
Dynamic Change in Cells Expressing IL-1β in Rat Hippocampus after Status Epilepticus

Neurological Toxicity in Metastatic Colorectal Cancer Patients Treated with Modified FOLFOX6 Plus Bevacizumab

Journal of Central Nervous System Disease
Molecular Network Analysis Suggests a Logical Hypothesis for the Pathological Role of C9orf72 in Amyotrophic Lateral Sclerosis/Frontotemporal Dementia

Journal of Medical Education and Curricular Development
Food for Thought: The Process of Bringing a Universal Medical Curriculum to the Plate – Part I of III

Can Reflective Writing Reconcile ACGME Core Competencies with Daily Encounters in Medical Education? A Prospective, Randomized, Cross-over Pilot Study

Lymphoma and Chronic Lymphocytic Leukemias
New Therapies in T-cell Lymphoma

Open Journal of Cardiovascular Surgery
Bedside Surgery to Treat Patent Ductus Arteriosus in Low-Birth-Weight Premature Infants

Ophthalmology and Eye Diseases
Time-dependent Gene Profiling Indicates the Presence of Different Phases for Ischemia/Reperfusion Injury in Retina

Perspectives in Medicinal Chemistry
Antibiotics and Bacterial Resistance in the 21st Century

Primary Prevention Insights
Obesity Prevention in Children from Birth to Age 5

Nutrition and Metabolic Insights
Relationship Between Urinary Concentrations of Nine Water-soluble Vitamins and their Vitamin Intakes in Japanese Adult Males

Mango Supplementation Improves Blood Glucose in Obese Individuals

Reproductive Biology Insights
Immunobiology of Spermatozoa: A Review

Tobacco Use Insights
Does Increased Knowledge of Risk and Complication of Smoking on Diabetes Affect Quit Rate? Findings from a Randomized Controlled Trial in Kerala, India

New PubMed Journal Added

We are pleased to announce that our Journal of Experimental Neuroscience has been added to Pubmed. This brings the total number of Libertas Academica journals included on Pubmed to 39.

Having our journals included in Pubmed means enhanced visibility for published papers and permanent archiving of papers in Pubmed Central in addition to our existing archiving arrangements with CLOCKSS and LOCKSS. It also means all newly published papers will be added to Pubmed within approximately ten days following publication.

The full list of all our Pubmed journals, can be found on our Journal Page.

Tuesday, August 26, 2014

Dr Punyadeera on Biomarkers in Cancer Research and Treatment

Head and neck cancer (HNC) is a general term given to a range of different cancers that occur in areas such as the mouth, nose and throat. Head and neck cancer is the 6th most common cancer in the world and is a deadly disease. Approximately 50% of patients survive to 5 years, and surgery and chemoradiotherapy can leave survivors with pain, disfigurement, and disability that further add to the burden of the disease. One reason for poor survival is late diagnosis, leading to delayed treatment when the cancer has spread to the other vital organs. While smoking and tobacco use are still major risk factors, the fastest growing cohort of HNC patients consists of young, healthy and non-smoking individuals who have been infected with the human papilloma virus (HPV).  Whilst the prognosis is relatively good for patients diagnosed with HPV-positive HNC, the prognosis for HPV-negative patients is dim.  Early diagnosis of HNC, especially in HPV-negative patients would have a profound impact on the long term survival of these patients.

Human saliva has gained momentum as a diagnostic fluid due to its non-invasiveness, ease of collection, and the fact that it lends itself easily to multiple sample collections in large population groups. Saliva also mirrors body’s health and wellbeing and saliva is a window to systemic events. This implies that we can use human saliva to diagnose and monitor systemic diseases.  As such, saliva represents an ideal testing material, especially considering its topical relevance to HNCs; tumour cells are often shed into the oral cavity and connected passages where they could be detected by saliva testing.

Biomarkers are traceable substances found in body fluids or tissues that can be useful in detecting and predicting diseases. One such biomarker is DNA methylation (chemical modification of DNA), which has an effect on gene expression. During cancer initiation, tumour suppressor genes (guardian angels of the human genome) are methylated. As a result vital genes that protect us from cancer are turned off. In order to provide new diagnostic biomarkers with higher sensitivity and specificity, we set out to identify novel methylation sites in the region of MED-15/PCQAP gene. In this gene, we have identified novel cancer specific methylation sites in the tumour samples from HNC patients. These DNA methylation events were also searched for in saliva samples collected from a different cohort of HNC patients (who developed cancer due to smoking or HPV infections) and healthy controls. The methylation ‘fingerprints’ turned up in the HNC patients who were HPV-negative. But did not turn up in the saliva collected from HPV-positive HNC patients. So, DNA methylation of PCQAP can be used as a diagnostic biomarker in HPV-negative HNC patients.

While HNC receives less attention than other more prevalent forms of common cancers (i.e. breast, prostate and colorectal), it remains an important health problem with substantial costs to society. Given the increasing rates of HNC in the world, the development of a screening program using these DNA methylation biomarkers would have a major international impact on cancer care and cancer control. We envision that a screening program using saliva as a diagnostic fluid would result in a change in current clinical paradigm by introducing for the first time, HNC-screening services significantly reducing mortality and morbidity.

Dr Chamindie Punyadeera is one of the authors of the recently published paper DNA Methylation at the novel CpG sites in the promoter of MED15/PCQAP gene as a biomarker for head and neck cancers, available for download now in Biomarker Insights.

Interview with Dr Nava Blum

This author interview is by Dr Nava Blum, of Max Stern Academic College of Emek Yezreel, Israel.  Dr Blum's full paper, Ambulatory and Hospital-Based Quality Improvements Methods in Israel, is available for download in Health Services Insights.

First please summarise for readers the content of your article.

In our review article, we described the ambulatory and hospital-based quality improvement methods in Israel. While many OECD countries are currently striving to improve ambulatory care, Israel’s efforts over the past decade have resulted in the development one of the most sophisticated programs to monitor the quality of ambulatory care. On the other hand, quality of ambulatory care monitoring does not spread out to Israel’s hospitals.

How did you come to be involved in your area of study?

This area (improving quality and effectiveness of health care and risk management) is part of my academic activities as a senior researcher and senior lecturer at the Max Stern Academic College of Emek Yezreel, (Department of Health Systems Administration).

What was previously known about the topic of your article?

In Israel,quality control and risk management are relatively new modalities that were created to keep a safe environment for patients at the hospital and in the community. The hospital based quality control was not highly developed in Israel partly because of ignorance unfamiliarity inexperience and unawareness, and partly because of arrogance, and lack of competition between hospitals in that area.

How has your work in this area advanced understanding of the topic?

My study exposed the “naked king” in the area of hospital monitoring and the need to create and implant an official quality of care monitoring program in hospitals. The OECD report specified certain essential issues which required attention from the Israeli Ministry of Health (MOH) who are now trying to narrow the gap between ambulatory and hospi¬tal quality monitoring. My paper compares the community vs. the hospital programs and suggests future goals.

What do you regard as being the most important aspect of the results reported in the article?

Recently, the MOH decided to develop new regulations and started to implement a hospital quality initiative plan in order to access hospitals’ healthcare quality indicators. It is possible that in the future it will allow monitoring medical treatment outcomes, medical proce¬dures, patient satisfaction, and the level of investment in safety quality measures that will be used to update improvements in hospitals care. The method for evaluating hospitals must be one of the top issues on the agenda of the leaders of the Israeli health system. The hope is that in a few years, the development of a national dataset will allow hospitals to compare their per-formance relative to other hospitals in Israel and worldwide and may be used to direct improvement in care.

Dr. Nava Blum, B.PT, M.Occ.H, PhD
Senior Lecturer
Department of Health Systems Administration,
Max Stern Academic College of Emek Yezreel, Israel

Dr E. Turon-ViƱas on Vanishing White Matter Disease

Vanishing white matter disease (VWMD) is one of the most prevalent hereditary white matter diseases. It is also known as childhood ataxia with central hypomyelination (CACH) and was first described by Van der Knaap et al in 1996.

It typically appears in a previously healthy child and produces a progressive neurological deterioration with some acute exacerbations secondary to infections, cranial trauma, or acute fright. Typical signs and symptoms comprise an initial motor deterioration, with pyramidal signs and cerebellar ataxia and a cognitive impairment which is less evident and appears later. There can be epileptic seizures, tremor, dystonia, or chorea and can also produce optic atrophy and progressive macrocephaly.

The most frequent clinical forms of the disease have their onset during childhood: the early childhood-onset appears before five years of age, and the late childhood-onset between ages five and fifteen. The disease may have a chronic progressive course or an acute form, and it is difficult to predict the evolution that each patient will follow even though some efforts to find a correlation between genotype and phenotype have been made. It is also worth noting that the evolution can be different even among affected members of the same family.

MRI images show important diffuse abnormalities of the signal on T1 and T2 of almost all the cerebral white matter, sparing the U fibers, with progressive rarefaction and cystic degeneration that leads to its complete disappearance. Even in the end-stage, when almost all white matter is cystic,  atrophy is usually mild if any.

On proton density and FLAIR images, within the rarified and cystic white-matter, a stripe-like pattern can be found, which represent remaining tissue strands.

Proton magnetic-resonance spectroscopy shows normal signals at the beginning but they progressively disappear and a spectrum similar to that of cerebrospinal fluid (CSF) can be recognised.

Genetic studies have proved an association between this disease and molecular mutations in five genes (eIF2B1-5) encoding the five subunits of eukaryotic translation initiation factor eIF2B (eIF2Ba-e), with the mutations in eIF2B5 being the most frequent ones.

EIF2B is responsible for initiating mRNA translation to polypeptides, and therefore it is essential to protein synthesis. It is also known that cells are prepared for protein synthesis inhibition in stress situations, to save energy and to prevent denatured proteins from accumulating. Under stress, eIF2B is inactivated, and therefore mRNA translation cannot begin. It has been reported that mutations in the genes encoding eIF2B could affect protein synthesis inhibition, rendering the cell more vulnerable to stress. Since this situation affects oligodendrocytes, which are the responsible cells for myelin synthesis, eIF2B mutations would end in an alteration of myelin production.

To date no curative treatment has been found. What seems to be effective is the prevention of the acute deterioration, avoiding cranial trauma and treating infection aggressively. Nevertheless, chronic progression is unavoidable.

Dr Turón-Viñas is author of the recently published paper Vanishing White Matter Disease in a Spanish Population, available for download now in Journal of Central Nervous System Disease.

SJR h-index rankings

The SCImago Journal & Country Rank is a portal that includes the journals and country scientific indicators developed from the information contained in the Scopus® database.

The SJR indicator uses an iterative algorithm and begins by setting an identical amount of prestige to each journal, then using an iterative procedure, this prestige is redistributed in a process where journals transfer their achieved prestige to each other through citations.

A list of the Libertas Academica journals with 2014 SJR h-index rankings can be found on our website;

 http://www.la-press.com/about_us.php?folder_id=128#pagelink_1305