Wednesday, March 24, 2010

Author interview with Dr Thomas Ostermann

Dr Ostermann is the author of Linguistic Processing and Classification of Semi Structured Bibliographic Data on Complementary Medicine which was recently published in Cancer Informatics.

The Editor in Chief of Cancer Informatics recently issued a call for papers.

What is the primary focus of your research?

I am working at the Center of Integrative Medicine at Witten/Herdecke University with two main topics:
  • The development and application of methods for Health Services Research
  • The use of modern web-technology for the creation of databases like CAMbase (www.cambase.de) or Arthedata (www.arthedata.de) Both topics serve to strenghten the Evidence-base of Complementary and Alternative Medicine (CAM)
What are the most exciting developments arising from current research in your area?

It is fascinating to see how things develop in the field of web technology. Almost 10 years ago we started our CAMbase project, a database on CAM and were faced with problems like server response times, speed of internet access and so on, which nowadays do not play that role anymore. Additionally new semantic web standards like XML have been developed and is quite amazing to see the new possibilities alongside this innovations.

This has influenced our work dramatically and were are now capable to develop database features like "tag clouds" which were impossible 10 years ago.

Who are your main collaborators? Please describe your work with them.

There is of course my team Christa Raak and Hartmut Zillmann with with whom I have been working for the past years. Our main collaborators are the Institutes for Art Therapy Research at the Universities in Nuertingen and Ottersberg (both in Germany). They had the idea of developing a bibliographical database on Art Therapy. As a mathematician working in medicine I am trying to identify the needs of our partners and "translate" them into technical terms (i.e. database structures) which then are realized by Hartmut. Normally this process quickly converges towards a fixed state.

Anther important and much younger collaboration is given with the ICCR-project. ICCR is a international collaboration of national and/or government-funded online complementary and alternative medicine (CAM) information providers which tries to map the landscape of Internet resources on CAM, develop guidelines on aspects of CAM information provision and bring togehter the main actors of this field. CAMbase was one of the centers that initiated the start-up of the ICCR in 2007 and we are meeting on a regular basis to discuss new information trends particularly with respect to patient information.

How did you come to be working in your research area?

After finishing my PhD on speech recognition in 1998 at my university I was looking for a academic position within the limits of mathematics and medicine. At that time the German government-funded project "Unconventional Medical Approaches (German acronym: UMR) was searching for a methodologist for health services research in CAM and I was quite impressed about the possibilities and ideas within that field. One of the tasks was to bring a database of self-collected bibliographical metadata online. That was the start of CAMbase and after a prototype was finished we made an application the the German Research Council (DFG) which was voted positive. From that point new projects (and also new funders like the Software AG Foundation) came in and this is how it all began.

What do you think about the development of open access publishing?

When we developed CAMbase one of our internal rules was that bibliographical information should be free and accessable for everyone without registration fees. I remember that not all of our contacts at that time agreed on that but that was our idea behind CAMbase. At that time (I suppose it was in 2000) the first Open access publishers started and we thought that this is in congruence with our ideas. From a personal point of view I like the idea that full-texts of my research are available through MEDLINE with only one or two mouse-clicks.

What articles and/or books have you published recently?

Recently I have published several articles with my colleague Elke Jeschke about prescribing patterns in a network of CAM-physicians, i.e.

Jeschke E, Ostermann T, Vollmar HC, Kroz M, Bockelbrink A, Witt CM, Willich SN, Matthes H. Evaluation of prescribing patterns in a German network of CAM physicians for the treatment of patients with hypertension: a prospective observational study. BMC Fam Pract.; 10(1):78.

Another quite recent article deals with "Knowledge transfer for the management of dementia: a cluster randomised trial of blended learning in general practice" where I am a co-author.

The last article I would like to mention is a methjodological paper on "Regression toward the mean--a detection method for unknown population mean based on Mee and Chua's algorithm." published with my colleague Rainer Lüdtke in BMC Med Res Methodol. 2008;8:52.

Further information:

Thursday, March 11, 2010

Author interview with Dr Yoshihito Yokoyama

Dr Yokoyama is the author of Clofibric Acid, a Peroxisome Proliferator-activated Receptor Alpha Ligand, Enhances a Suppressive Effect of Cis-diaminedichloroplatinum on Proliferation of Ovarian Carcinoma Cells which was recently published in Clinical Medicine Insights: Oncology.

The Editor in Chief of Clinical Medicine Insights: Oncology recently issued a call for papers.

Please describe your experience with Libertas Academica:

I found that the quality of the review was high and the review and publication process was very well-ordered. All readers can easily access the articles and I believe that they feel satisfied with excellent works in the articles.

What is the primary focus of your research?

Development of new therapeutic strategy for epithelial ovarian cancer focusing on anti-angiogenesis and induction of apoptosis and development of new medicine capable of inducing anti-angiogenesis and apoptosis.

What are the most exciting developments arising from current research in your area?

Photodynamic therapy using a methyl ester of 5-aminolevulinic acid was effect on inhibition of ovarian cancer growth.

Who are your main collaborators? Please describe your work with them.

Dr Shigeki Tsuchida. Clofibric Acid, a Peroxisome Proliferator-Activated Receptor α Ligand Inhibits Growth of Human Ovarian Cancer.

How did you come to be working in your research area?

My theme of doctorate course was "Identification of the protein induced in rat liver by clofibrate administration and its changes during hepatocarcinogenesis". Then, I became a gynecologic oncologist and have continued the research for chemoresistance and biology of ovarian cancer.

What do you think about the development of open access publishing? What motivated you to do so?

It is very significant and open access publishing can encourage young scientists to submit their research results.

What articles and/or books have you published recently?
  • Efficacy of a methyl ester of 5-aminolevulinic acid in photodynamic therapy for ovarian cancers . J Cancer Res Clin Oncol in press Endostatin inhibits xenografted human ovarian cancer growth. Cancer Therapy 2009; 7: 347-353.

  • Two cases of ovarian cancer at an early stage incidentally detected using transvaginal ultrasonography in screening: Importance of interval for ovarian cancer screening and selection of population with a high risk of ovarian cancer. Eur J Gynaecol Oncol 2009; 30: 208-210.

  • A phase II multicenter trial of concurrent chemoradiotherapy with weekly nedaplatin in advanced uterine cervical carcinoma: Tohoku Gynecologic Cancer Unit Study. Oncol Rep 2008; 19: 1551-1556.
Further information:

Author interview with Dr Ross Grant

Dr Grant is the author of The Physiological action of Picolinic Acid in the Human Brain which was recently published in International Journal of Tryptophan Research.

The Editor in Chief of International Journal of Tryptophan Research recently issued a call for papers.

Dr Grant is a member of our favorite authors program. Under the program authors are eligible to receive: prioritized peer review, prioritised author PDF, and an article processing fee discount. All former authors are eligible to join the favorite authors program.

Please describe your experience with Libertas Academica:

Excellent turnaround time. Access to very relevant readership

What is the primary focus of your research?

KP metabolism and it role in NAD+ synthesis. NAD+ metabolism and its role in health and disease, particularly in the central nervous system.

What are the most exciting developments arising from current research in your area?

We have recently shown that NAD+ levels decrease in the brain and other tissue during the aging process, in line with increased oxidative stress and DNA damage. However when NAD+ synthesis is enhanced cells of the CNS and skin appear more resilient to oxidative stress. This has significant relevance to aging and degenerative disease

Who are your main collaborators? Please describe your work with them.
  • Dr Guillemin (University of NSW, Sydney Australia) has been a long standing collaborator on the molecular characterization of the kynurenine pathway in various cell types.

  • Prof Tailoi Chan ling (University of Sydney, Australia), has more recently contributed significantly to work in our aged animals.

  • Prof Manohar Garg (University of Newcastle, Australia), is also working with us on characterization of oxidative stress in the central nervous system.
How did you come to be working in your research area?

KP metabolism and NAD+ synthesis have been a significant research interest since doing a brief sabbatical at James Cook university a number of years ago with Prof Vimal Kapoor (now at University of Western Australia). Dr Kapoor was an excellent motivator and our interesting discussions on the topic helped to create a life long interest.

What articles and/or books have you published recently?
  • Braidy N, Grant R, Adams S, Guillemin G. Neuroprotective Effects of Naturally Occurring Polyphenols on Quinolinic Acid-Induced Excitotoxicity in Human Neurons. FEBS J. 277(2):368-82. 2010

  • Yiquan Chen, Roger Stankovic, Karen Cullen, Vincent Meininger, Brett Garner, Sarah Coggan, Ross Grant, Bruce J. Brew, and Gilles J. Guillemin The Kynurenine Pathway and Inflammation in Amyotrophic Lateral Sclerosis. Neurotox Res. 2009 Nov 18.

  • Brady N, Grant R, Guillemin G. Mechanism for Quinolinic Acid Cytotoxicity in Human Astrocytes and Neurons. Neurotox Res 16(1):77-86 2009

  • Grant RS, Coggan S, Smythe GA. The Physiological action of Picolinic Acid in the Human Brain. (invited Review). Int. J. Tryp. Res. 2:71-79 2009

  • Braidy N Grant R, Brew BJ, Adams S, Jayasena T, Guillemin G. Effects of Kynurenine Pathway Metabolites on Intracellular NAD+ synthesis and Cell Death in Human Primary Astrocytes and Neurons. Int J. Tryp. Res. (in press) 2009

  • Coggan S, Smythe G, Bilgin A, Grant R. Age and Circadian Influences on Picolinic acid concentrations in human Cerebrospinal Fluid. J. Neurochem. 108:1220-1225 2009
Further information:

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